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Biomedical Engineering and Bioengineering
Weldon School of Biomedical Engineering Faculty Publications
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A Novel Open Field Activity Detector To Determine Spatial And Temporal Movement Of Laboratory Animals After Injury And Disease, Andrew O. Koob, John Cirillo, Charles F. Babbs
A Novel Open Field Activity Detector To Determine Spatial And Temporal Movement Of Laboratory Animals After Injury And Disease, Andrew O. Koob, John Cirillo, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Among the wide range of tests for laboratory animal behavior after neurological injury or disease, each has its benefits and drawbacks. The varied behavior that an animal exhibits makes it difficult to decide which test to use. However, a fundamental instinct for the laboratory animal is to explore when placed in a new environment. A way to test exploratory behavior is in the open field. Here, we introduce a simple activity box without the use of video equipment to determine the exploratory movement of a rat after traumatic brain injury. The activity box is an open field, and the rat …
Design Of Near-Optimal Waveforms For Chest And Abdominal Compression And Decompression In Cpr Using Computer-Simulated Evolution, Charles F. Babbs
Design Of Near-Optimal Waveforms For Chest And Abdominal Compression And Decompression In Cpr Using Computer-Simulated Evolution, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Objective: To discover design principles underlying the optimal waveforms for external chest and abdominal compression and decompression during cardiac arrest and CPR. Method: A 14-compartment mathematical model of the human cardiopulmonary system is used to test successive generations of randomly mutated external compression waveforms during cardiac arrest and resuscitation. Mutated waveforms that produced superior mean perfusion pressure became parents for the next generation. Selection was based upon either systemic perfusion pressure (SPP=thoracic aortic minus right atrial pressure) or upon coronary perfusion pressure (CPP=thoracic aortic pressure minus myocardial wall pressure). After simulations of 64,414 individual CPR episodes, 40 highly evolved waveforms …
A New Biomechanical Head Injury Criterion, Charles F. Babbs
A New Biomechanical Head Injury Criterion, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
This paper presents a new analysis of the physics of closed head injury caused by intense acceleration of the head. At rest a 1 cm gap filled with cerebrospinal fluid (CSF) separates the human brain from the skull. During impact whole head acceleration induces artificial gravity within the skull. Because its density differs slightly from that of CSF, the brain accelerates, strikes the inner aspect of the rigid skull, and undergoes viscoelastic deformation. Analytical methods for a lumped parameter model of the brain predict internal brain motions that correlate well with published high-speed photographic studies. The same methods predict a …