Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Concussion (2)
- 3D nanofibers (1)
- American Football (1)
- Bevacizumab (1)
- Bone tissue engineering (1)
-
- Brain Connectivity (1)
- Brain Injury (1)
- Brain stem (1)
- Cardiac (1)
- Cell encapsulation (1)
- Child pedenstrian (1)
- Chitosan (1)
- Connectivity domain (1)
- Diffusion MRI (1)
- Electrospinning (1)
- Extracellular Matrix (1)
- FMAU (1)
- Finite element modeling (1)
- Glycosaminoglycans (1)
- Growth plate (1)
- Helmet weight (1)
- Human body modeling (1)
- Laboratory impactor (1)
- Liposome (1)
- Macrophages (1)
- Material test (1)
- Mechanics (1)
- Meniscus (1)
- Mild Traumatic Brain Injury (1)
- Modular tissue engineering (1)
Articles 1 - 9 of 9
Full-Text Articles in Entire DC Network
Brain Connectivity After Concussion, Armin Iraji
Brain Connectivity After Concussion, Armin Iraji
Wayne State University Dissertations
Mild traumatic brain injury (mTBI) accounts for over one million emergency visits in the United States each year. While most mTBI patients have normal findings in clinical neuroimaging, alterations in brain structure and functional connectivity have frequently been reported. In this study, we investigated the large-scale brain structural and functional connectivity using diffusion MRI and resting-state fMRI data. Data from 40 mTBI patients was acquired at the acute stage (within 24 hrs after injury). 35 patients returned for data acquisition at a follow-up (4-6 weeks after injury). Data was also collected from a cohort of 58 healthy subjects, 36 of …
Mri Methods For Imaging The Feto-Placental Vasculature And Blood, Uday Krishnamurthy
Mri Methods For Imaging The Feto-Placental Vasculature And Blood, Uday Krishnamurthy
Wayne State University Dissertations
Fetal magnetic resonance imaging (MRI) in recent times has become a well-established adjunct to ultrasound (US) in routine clinical prenatal care and diagnostics. The majority of fetal MRI is restricted to T2-weighted scans, where the diagnosis is based on the appearance of normal and abnormal tissue. Although there have been many advancements in MRI and a plethora of sequences, that probe different anatomical and different physiological process, the adaptation of these in fetal imaging has been rather slow. Many of these can extract quantitative parameters that can throw light on the underlying tissue’s normal/patho-physiology. But the use of such quantitative …
Pet Imaging Of Early Therapeutic Response In Solid Tumors, Stephanie J. Blocker
Pet Imaging Of Early Therapeutic Response In Solid Tumors, Stephanie J. Blocker
Wayne State University Dissertations
An important pillar of precision medicine for oncology is the ability to identify patients who respond to treatment early into their therapy. Positron emission tomography (PET) allows physicians and researchers to measure changes in tumor behavior prior to noticeable differences in morphology.
Objective: Determine the utility of multiple tracers for PET in assessing early changes in tumor activity that result from treatment.
Methods: Two tracers for PET were studied. 64Cu-labeled liposomes were used to assess changes in liposome delivery two solid colon tumors early into treatment with bevacizumab (Bev). 18F-FMAU thymidine analog (1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)thymine), was utilized to detect early response to …
Biomechanics Of Concussion: The Importance Of Neck Tension, Ron Jadischke
Biomechanics Of Concussion: The Importance Of Neck Tension, Ron Jadischke
Wayne State University Dissertations
Linear and angular velocity and acceleration of the head are typically correlated to concussion. Despite improvements in helmet performance to reduce accelerations, a corresponding reduction in the incidence of concussion has not occurred (National Football League [NFL] 1996 – present).
There is compelling research that forces on and deformation to the brain stem are related to concussion. The brain stem is the center of control for respiration, blood pressure and heart rate and is the root of most cranial nerves. Injury to the brain stem is consistent with most symptoms of concussion reported in the National Football League and the …
Design Of A Modular Endothelialized Platform For Vascularized Bone Regeneration, Kevin Barrett Miles
Design Of A Modular Endothelialized Platform For Vascularized Bone Regeneration, Kevin Barrett Miles
Wayne State University Dissertations
The gold standard for bone regeneration requires harvesting a piece of healthy bone from the patient through a painful procedure, but this piece of autologous bone graft contains the bone and endothelial cells required to rapidly regenerate bone in a defect. We have developed a modular bone regeneration platform, composed of mesenchymal stem cells (MSCs) and hydroxyapatite (HAP) microgranules encapsulated in microcapsules, to replace autologous graft harvesting. The microcapsules are composed of a polyelectrolyte membrane formed by the ionic-complex reaction between chondroitin 4-sulfate (C4S) and chitosan. The specific aims of this thesis were to 1) examine the ability of C4S/HAP/chitosan …
Development Of A Finite Element Pelvis And Lower Extremity Model With Growth Plates For Pediatric Pedestrian Protection, Ming Shen
Wayne State University Dissertations
Finite element (FE) model is a useful tool frequently used for investigating the injury mechanisms and designing protection countermeasures. At present, no 10 years old (YO) pedestrian FE model has been developed from appropriate anthropometries and validated against limitedly available impact response data. A 10 YO child FE pelvis and lower extremities (PLEX) model was established to fill the gap of lacking such models in this age group. The baseline model was validated against available pediatric postmortem human subjects (PMHS) test data and additional scaled adult data, then the PLEX model was integrated to build a whole-body FE model representing …
Mechanical Interventions In Soft Tissue Repair, Elizabeth Marie Meier
Mechanical Interventions In Soft Tissue Repair, Elizabeth Marie Meier
Wayne State University Dissertations
This body of work sets to investigate some of these mechanical interventions that are designed to promote wound healing, repair, or even replace an injured tissue. By investigating three separate tissues and three separate mechanical interventions, we can draw conclusions about the implications of including mechanical interventions in biomedical research and clinical treatments. The use of sutures to close wounds is highly common, however the effects of sutures on the tensile mechanics of human skin are largely unknown. To evaluate how sutures may affect uniaxial tensile mechanics, human skin samples were sutured and loaded in tension in multiple orientations. The …
Biomaterials Approaches For Utilizing The Regenerative Potential Of The Peripheral Nerve Injury Microenvironment, Melissa Renee Wrobel
Biomaterials Approaches For Utilizing The Regenerative Potential Of The Peripheral Nerve Injury Microenvironment, Melissa Renee Wrobel
Wayne State University Dissertations
Clinically available treatments are insufficient to achieve full functional recovery in large (>3cm) peripheral nerve injuries (PNI). The objectives in this thesis were 1) to study often overlooked elements of intrinsic PNI repair including release of inhibitory CSPGs and post-injury responses of inflammatory macrophages and dedifferentiated Schwann cells; 2) to create biomaterial scaf-folds featuring topographical and adhesive cues to enhance neurite outgrowth; and 3) to test the ability of those cues to direct macrophages and Schwann cells towards a pro-regenerative phe-notype. It is hypothesized that recapitulating the positive and negative cues of the PNI microenvi-ronment can better improve regeneration. …
Development Of A Programmed Electrospun Three Dimensional (3d) Nanofiber Collecter And It’S Application To Orthopedic Implant Coatings, Liang Chen
Wayne State University Dissertations
Orthopedic implants might not directly unite with bones especially in compromised patients even if they have been appropriately fixed. The lack of early osseointegration would lead to the failure of the orthopedic implant. A “bone-like” implant surface is urgently needed to accelerate osseointegration. Electrospun nanofiber (NF) is a promising implant coating due to its highly porous nanoscale structure. It mimics the collagen I nanofibrous network of bone tissue; meanwhile it has been widely used as a drug delivery device. However, its compact and dense structure is not ideal for cell growth. Our strategy was to develop a functional three-dimensional (3D) …