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- Near infrared lasers (2)
- 3-D pendulum tree system (1)
- Altered functional connectivity (1)
- Biodegradable nanofibers (1)
- Bisphosphonate treatment (1)
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- Bone tissue engineering (1)
- Cerebral ischemia (1)
- Chitosan nanofiber scaffolds (1)
- Cortical bone tissue (1)
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- Dynamic joint reaction (1)
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- Idealized flexible model (1)
- In vitro drug screening (1)
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- Low power NIR laser irradiation (1)
- Micropatterned agarose hydrogels (1)
- Nanomedical drug delivery (1)
- Negative pressure wound therapy (1)
- Nerve tissue repair (1)
- Neural response (1)
- Neural stimulation (1)
- Penumbra (1)
- Physical therapy (1)
- Prehension (1)
- Spike triggered averaging (1)
- Spinal cord injury (1)
- Stroke rehabilitation (1)
- Temperature distribution (1)
- Three-dimensional (3-D) liver model (1)
Articles 1 - 12 of 12
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Analysis Of Tissue Engineering Strategies For Bone-Related Applications, Timothy Buirkle
Analysis Of Tissue Engineering Strategies For Bone-Related Applications, Timothy Buirkle
Theses
Over the past few decades, tissue engineering approaches have pushed their way to the forefront of biotechnological research and development, serving a wide variety of applications. This research utilizes quantitative methods to analyze the outcome of two bone tissue engineering studies. In an in vivo study, the use of Negative Pressure Wound Therapy (NPWT) in combination with stem cell-loaded scaffolds was investigated for the repair of large bone defects. Quantitative histological analysis was performed by determining both the percentage of cells proliferating (BrdU), as well as cells expressing bone-specific markers of alkaline phosphatase (A L P) in the defect. Total …
Fmri Assessment Of Ischemic Stroke In Humans, Rui Yuan
Fmri Assessment Of Ischemic Stroke In Humans, Rui Yuan
Theses
Cerebral ischemia, or brain ischemia is a kind of stroke where the blood flow is insufficient to the metabolic demand of brain. The lack of oxygen supply will directly lead to the death of brain tissue. There are two major injury regions: the infarct and penumbra. Mostly, since the infarct regions became dead tissues rapidly after stroke, there is a tiny possibility to rescue them in time. But penumbra parts are different. Tissues there will be viable for hours after ischemia. Hence, both theoretically and practically, it is possible to salvage those cells in the penumbra region. Diffusion weighted image …
Quantifying Prehension In Persons With Stroke Post Rehabilitation, Saumya Sara Puthenveettil
Quantifying Prehension In Persons With Stroke Post Rehabilitation, Saumya Sara Puthenveettil
Theses
This study describes the analysis of reaching and grasping abilities of the hemiparetic arm and hand of patients post stroke after a series of interactive virtual reality (VR) simulated training sessions and conventional physical therapy of similar intensity. Six subjects participated in VR training and five subjects in clinical rehabilitation for two weeks. Subjects’ finger joint angles were measured during a kinematic reach to grasp test using CyberGlove® and arm joint angles were measured using the trackSTARTM system prior to training and after training. Downward force applied to the object during grasping was assessed using Nano17TM, a force/torque sensor system …
Alterations In Brain Connectivity After Spinal Cord Injury Using Functional Mri, Yamin Ahmed Noor
Alterations In Brain Connectivity After Spinal Cord Injury Using Functional Mri, Yamin Ahmed Noor
Theses
Every year, approximately 50 people per million of inhabitants are inflicted by Spinal Cord Injury (SCI). The long-term impairment of the SCI patients has led researchers to investigate different rehabilitation and treatment efforts that require careful observations to be made on reliable markers. Presently, a number of neuropsychological assessments are used for SCI rehabilitation and research purposes. However, there is a need for the discovery of sensitive biomarkers that can be used to characterize SCI. Altered functional connectivity in the brain has been observed in a number of neurological patient populations. Hence, it was hypothesized that such alterations in brain …
Experimental Evaluation Of Near Infrared Light Penetration Into Neural Tissue, Ujwal Anil Parikh
Experimental Evaluation Of Near Infrared Light Penetration Into Neural Tissue, Ujwal Anil Parikh
Theses
Near infrared (NIR) lasers find applications in medicine both for diagnostic and treatment purposes. Penetration depth into the tissue is a critical parameter to be considered in these NIR laser applications. Published data on the optical properties of rodent neural tissue are rare, despite the frequent use of rats as animal models. The aim of this study was to directly measure the light intensity profile inside the rat brain gray matter that is illuminated by an NIR laser beam. The local light intensities were sampled using an optical fiber inserted into the brain. The intensity profile in the axial direction …
Alendronate Treatment Elicits A Reduction In Fatigue-Life Of Canine Cortical Bone, Joseph Ryan Geissler
Alendronate Treatment Elicits A Reduction In Fatigue-Life Of Canine Cortical Bone, Joseph Ryan Geissler
Theses
Bone serves contradictory needs; bone must be strong yet light, and stiff yet flexible. At the tissue level bone material withstands cyclic loading without failing by dissipating energy via the formation and accumulation of microdamage. Proper removal of this damage in exchange for fresh tissue is vital to bone maintenance, and is achieved through a remodeling process. Imbalanced remodeling leads to osteoporotic fractures. Bisphosphonate drugs are proven to reduce fracture risk. However, the long-term effects of bisphosphonates on tissue-level properties are unknown. This study characterized the fatigue-life of cortical bone tissue after bisphosphonate treatment with alendronate (Aln). 1 1th ribs …
Neural Differentiation Of Pluripotent Stem Cells And Applications To Micropatterned Agarose Hydrogel For Nerve Guidance, Jamila S. Gittens
Neural Differentiation Of Pluripotent Stem Cells And Applications To Micropatterned Agarose Hydrogel For Nerve Guidance, Jamila S. Gittens
Theses
Many central nervous system (CNS) disorders are attributable to damaged oligodendrocytes, the cells that form the myelin sheath of axons. An effective source of human oligodendrocytes is crucial, making pluripotent stem cells, such as embryonic stem (ES) cells, an attractive source for nerve tissue repair and regeneration due to their unlimited capacity for self-renewal and their ability to differentiate into all major cell lineages. Bioengineered 3-D hydrogel culture systems have the potential to elucidate mechanisms required for regeneration of CNS cells. The goals of this study are: (1) to investigate the effects of retinoic acid (RA), sonic hedgehog (shh) agonist, …
Soy Protein-Poly (L-Lactic Acid) Blend Nanofibers For Drug Delivery Of Nardostachys Jatamansi, Swetha Tiwari
Soy Protein-Poly (L-Lactic Acid) Blend Nanofibers For Drug Delivery Of Nardostachys Jatamansi, Swetha Tiwari
Theses
Electrospun nanofibers when nanofi bers are impregnated with drugs play a significant role in drug delivery. Nanomedical approaches to drug delivery focus on developing nanoscale particles or molecules to improve the bioavailab ility of a drug.
Biodegradable nanofibers were developed using Poly (L – lactic acid) and Soy protein for the delivery of an ayurvedic drug, Nardostachys jatamansi. A weighed quantity of powdered drug – Nardostachys Jatamansi was subjected to Soxhlet extraction using water and ethanol in equal quantities. Various blends of the drug extract and soy protein solution are prepared and mixed in Poly (L-lactic acid). Nanofibers of …
Development Of 3-D Liver Model For Drug Screening Applications, Divya Rajendran
Development Of 3-D Liver Model For Drug Screening Applications, Divya Rajendran
Theses
The need for a an in vitro drug screening system that mimics the structural organization of natural liver for multi-functionality and maintenance of hepatocytes has become vital in the drug development process. The objective of this study was to engineer a three-dimensional (3-D) liver model using chitosan-based nanofiber scaffolds and co-culture system (adult rat hepatocytes and 3T3-J2 fibroblasts) to mimic the natural liver and to justify its application for in vitro drug screening. Chitosan nanofiber scaffolds were fabricated by electrospinning technique. In order to promote cell adhesion on the chitosan scaffolds, the scaffolds were coated with a cell adhesion molecule, …
Neuralsta: A Software Tool For Neural Stimulation And Recording Applications With A Laser Control, Rimi Sahu
Neuralsta: A Software Tool For Neural Stimulation And Recording Applications With A Laser Control, Rimi Sahu
Theses
The subject of this thesis is a software tool created in Matlab ® for neural stimulation and recording of the evoked potentials. The stimulation output can be delivered in electrical units for immediate use for neural stimulation or as a power control signal to a laser. NeuralSTA is designed to generate arbitrary waveforms of stimulation and simultaneously record the neural response while implementing the spike triggered averaging (STA) method, hence the name NeuralSTA. The output (stimulation) signal can be created in monophasic, biphasic or inverted monophasic forms (for laser control applications). Controls for pulse modulation allow shaping of the pulse …
Theoretical Prediction Of Joint Reaction Force In A Dynamic General 3-D Pendulum Tree Model For Human Or Animal Motion, Sucheta Goyal
Theoretical Prediction Of Joint Reaction Force In A Dynamic General 3-D Pendulum Tree Model For Human Or Animal Motion, Sucheta Goyal
Theses
Lagrangian dynamics and the method of superfluous coordinates are applied to predict dynamic joint reaction forces in an idealized flexible model of a branched 3-D pendulum tree system. The number of segments and joints on the tree are adjustable as is the branching tree pattern. The segments that comprise the tree are assumed to be one- dimensional rigid rods containing a discrete set of mass points that is both flexible in number and distribution on the tree. The idealized 3-D pendulum tree system is intended to provide a flexible theoretical framework to model and better understand the dynamics of human …
Temperature Elevations Due To Nir Exposure In The Brain Tissue, Ali Ersen
Temperature Elevations Due To Nir Exposure In The Brain Tissue, Ali Ersen
Theses
Near infrared (NIR) lasers have been used in medical applications both for diagnostic and therapeutic purposes. Temperature elevation profile inside the tissue is a critical factor that needs to be better understood in these applications. The purpose of this study is to determine the temperature distribution due to a low power N I R laser irradiation in living neural tissue. Temperature measurements were made directly using a thermocouple probe inside the rat brain cortex within the sagittal plane. The spatial map indicates that N I R light penetrates more readily in the vertical directions than the spreading in the horizontal …