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Manipulation Of Gold Nanorod Physicochemical Properties To Enhance Biocompatibility, Uptake And Intracellular Preservation Of Optical Properties For Bio-Imaging And Plasmonic Photo-Therapeutic Applications, Anthony B. Polito
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Gold nanorods (GNRs) due to their tunable optical properties within the near infrared (NIR) region have been identified as strong candidates for new nano-based biomedical applications. Unfortunately, many have reported GNR cytotoxicity and it is still unclear how GNR aspect ratio (AR), surface charge and surface chemistry contribute to cellular association and cytotoxicity. GNR surface chemistry modifications have been reported to reduce cytotoxicity, however they can result in poor cellular uptake and loss of NIR optical properties preventing efficiency with bio-imaging and photo-thermal applications. The aim of this study was to determine if manipulation of GNR physicochemical properties could enhance …