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Engineering Hyaluronic Acid Carbon Nanotube Nanofibers: A Peripheral Nerve Interface To Electrically Stimulate Regeneration, Elisabeth M. Steel
Engineering Hyaluronic Acid Carbon Nanotube Nanofibers: A Peripheral Nerve Interface To Electrically Stimulate Regeneration, Elisabeth M. Steel
Wayne State University Dissertations
Peripheral nerve injuries annually affect hundreds of thousands of people globally. Current treatments like the gold standard autograft and commercially available nerve guide conduits (NGC) are insufficient to repair long gap peripheral nerve injuries. NGCs can aid recovery but lack key microenvironment cues that promote nerve regeneration. We hypothesized that providing topographical, mechanical, and electrical guidance cues through a nanofibrous composite biopolymer would result in improved neuron growth metrics using an in vitro model. We embedded hydrophilic carbon nanotubes (CNT) within hyaluronic acid (HA) nanofibers by electrospinning. The aims of this study were (1) to define the topographical, nanomechanical, and …
Development Of A Programmed Electrospun Three Dimensional (3d) Nanofiber Collecter And It’S Application To Orthopedic Implant Coatings, Liang Chen
Wayne State University Dissertations
Orthopedic implants might not directly unite with bones especially in compromised patients even if they have been appropriately fixed. The lack of early osseointegration would lead to the failure of the orthopedic implant. A “bone-like” implant surface is urgently needed to accelerate osseointegration. Electrospun nanofiber (NF) is a promising implant coating due to its highly porous nanoscale structure. It mimics the collagen I nanofibrous network of bone tissue; meanwhile it has been widely used as a drug delivery device. However, its compact and dense structure is not ideal for cell growth. Our strategy was to develop a functional three-dimensional (3D) …