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Assessing Midbrain Abnormalities In Parkinson’S Disease Using Magnetic Resonance Imaging, Kiarash Ghassaban
Assessing Midbrain Abnormalities In Parkinson’S Disease Using Magnetic Resonance Imaging, Kiarash Ghassaban
Wayne State University Dissertations
Diagnosing early-stage Parkinson’s disease (PD) and its manifestations is still a clinical challenge. Previous imaging studies using iron, neuromelanin (NM) and the Nigrosome-1 (N1) measures in the substantia nigra (SN) by themselves have been unable to provide sufficiently high diagnostic performance for these methods to be adopted clinically. In this dissertation, we start by studying idiopathic PD patients at their intermediate stages of the disease to evaluate the role of global and regional iron in the major deep gray matter nuclei. Then, we only focus on the NM complex in the midbrain and how neuronal loss interact with iron overload …
Measuring Brain Iron In Healthy Controls And Accessing Venous Abnormalities In Parkinson's Disease Using Mri, Manju Liu
Wayne State University Dissertations
Iron plays a key role in a number of brain cellular processes. However, abnormal brain iron regulation correlates with a number of neurodegenerative diseases such as Parkinson's disease, multiple sclerosis and so forth. To further elucidate the involvement of iron in neurodegenerative disorders, a robust in vivo quantitative non-invasive assessment of normal brain iron deposition over time is essential. A variety of magnetic resonance imaging (MRI) methods have been used to quantify iron both in vivo and in vitro non-invasively. We first created the baseline of phase value and ∆R2^* as a function of age in seven gray matter nuclei. …
Imaging Iron Content In Patients With Multiple Sclerosis Using Magnetic Resonance Imaging, Charbel Abdo Habib
Imaging Iron Content In Patients With Multiple Sclerosis Using Magnetic Resonance Imaging, Charbel Abdo Habib
Wayne State University Dissertations
The importance of iron in maintaining normal physiological processes in the human body has been well emphasized in the literature. However, "when iron behaves badly", its abnormal presence might lead to a spectrum of pathologies depending on what function has been altered. In the brain, for instance, abnormal iron content is thought to be associated with neurodegenerative diseases. In this dissertation, we study iron involvement in one of the most debilitating neurological diseases, multiple sclerosis (MS), using in vivo magnetic resonance imaging. We first test the sensitivity and specificity of the MR method used, known as susceptibility weighted imaging (SWI) …