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Articles 1 - 11 of 11
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Targeted Drug-Loaded Nanoparticle System (Tdnps) To Ameliorate And Treat Idiopathic Lung Fibrosis, Harish Ramachandramoorthy
Targeted Drug-Loaded Nanoparticle System (Tdnps) To Ameliorate And Treat Idiopathic Lung Fibrosis, Harish Ramachandramoorthy
Bioengineering Dissertations
Idiopathic pulmonary fibrosis (IPF) is a fatal progressive disease with a dismal prognosis and 3-5 years of survival. Up to date, there are no effective treatments, and a few current therapies that do not ameliorate the pulmonary fibrosis but rather just increase the survival time by 2-3 years. The major factor limiting the treatment is the lack of targeted therapies to deliver the drugs past the mucosa, into the disease microenvironment. To combat this disease, we proposed a localized therapy via our targeted drug-loaded nanoparticles (TDNPs) to effectively deliver drugs and treat lung fibrosis. Our objective was to design TDNPs …
Electrophysiological, Hemodynamic, And Metabolic Effects Of Transcranial Photobiomodulation (Tpbm) On Topographical And Physiological Connectivity In The Human Brain, Sadra Shahdadian
Bioengineering Dissertations
Transcranial photobiomodulation (tPBM) targets the human brain with near-infrared (NIR) light and is shown to affect human cognitive performance and neural electrophysiological activity as well as concentration changes of oxidized cytochrome-c-oxidase ([CCO]) and hemoglobin oxygenation ([HbO]) in human brain. Brain topographical connectivity, which shows the communication between regions of the brain, and its alteration can be assessed to quantify the effects of external stimuli, diseases, and cognitive decline, in resting-state or task-based measurements. Furthermore, understanding the interactions between different physiological representations of neural activity, namely electrophysiological, hemodynamic, and metabolic signals in the human brain, has been an important topic among …
Engineering Elastic And Functional Electrospun Nano-Fibers For Potential Heart Repair, Alan Mark Taylor
Engineering Elastic And Functional Electrospun Nano-Fibers For Potential Heart Repair, Alan Mark Taylor
Bioengineering Dissertations
In the United States and around the world, cardiovascular disease (CVD) has been one of the main causes of death since 1921, responsible for approximately 1 in 4 deaths domestically. Myocardial infarction (MI), or commonly called a heart attack, is a subset of CVD that often ends in heart failure (HF). Cardiac cells are incapable of regeneration, leading to severe impacts on quality of life. Current treatments for MI fail to target left ventricular remodeling and therefore do little to address the progression towards HF. Cardiac scaffolds for tissue engineering (TE) are a prominent solution in recent research. Developing various …
Advancing The Radiation Oncology Clinic With Motion Management And Automatic Treatment Planning, Damon Anton Sprouts
Advancing The Radiation Oncology Clinic With Motion Management And Automatic Treatment Planning, Damon Anton Sprouts
Bioengineering Dissertations
The leading cause of premature death (death under the age of 70) is cancer. The top five cancers for both male and female are: lung, colorectum, pancreas, breast cancer, and prostate. In 2020 there was an estimated 19.3 million new cases with an estimated 9.9 million deaths. The cancer burden is expected to grow to 28.4 million by the year 2040. Surgery, chemotherapy, and radiotherapy are the three pillars in the modern clinic for cancer treatment. In radiotherapy, ionizing radiation particles can travel through the patient body, deposit energy along the way and damage the DNA Structure. There needs to …
Novel Nanoparticles To Stimulate Therapeutic Angiogenesis For The Treatment Of Peripheral Arterial Diseases, Tam Phung Nguyen
Novel Nanoparticles To Stimulate Therapeutic Angiogenesis For The Treatment Of Peripheral Arterial Diseases, Tam Phung Nguyen
Bioengineering Dissertations
Peripheral arterial disease (PAD) is a severe impairment of arterial vessels resulting in obstruction of normal blood flow in the legs, leading to acute or chronic lower limb ischemia and subsequently high morbidity and mortality rates. Common treatments for PAD, such as medications and surgical revascularization, have several limitations. For instance, medications used to lower cholesterol, reduce high blood pressure, control blood sugar, prevent blood clots, and reduce/delay symptoms such as leg pains. Still, they cannot treat the established disease directly and often cause side-effects, including bleeding, headache, and diarrhea. Meanwhile, many elderly PAD patients cannot undergo surgical options. Therefore, …
Using Scratch Wound Assay To Study The Effect Of Soil Arsenic On Human Keratinocyte Cell Migration Due To Contact Exposure, Manas Warke, Laura De March, Srinivas Kannan, Madeline English, Rohan Sarkar, Rupali Datta, Smitha Rao
Using Scratch Wound Assay To Study The Effect Of Soil Arsenic On Human Keratinocyte Cell Migration Due To Contact Exposure, Manas Warke, Laura De March, Srinivas Kannan, Madeline English, Rohan Sarkar, Rupali Datta, Smitha Rao
Michigan Tech Research Data
The scratch wound assay was performed on Human immortalized keratinocytes (HaCaT) cells to observe the effect on cell migration due to contact exposure to arsenic-contaminated Immokalee soil. The cell migration was observed through a microscope for 72 h. HaCaT cells were seeded in 48-well plate. On day 3, treatment media was added (n=8). The cells were treated with four concentrations of soil As (45, 225, 450, and 900 mg/kg) and two controls - Negative control (NC; Pure media) and control (C; 0 mg/kg soil As) for 72 h. A scratch was made using a pipette tip. The wound healing was …
Using Scratch Wound Assay To Study The Effect Of Soil Arsenic On Human Dermal Fibroblasts Cell Migration Due To Contact Exposure, Manas Warke, Laura De Marchi, Srinivas Kannan, Madeline English, Rohan Sarkar, Rupali Datta, Smitha Rao
Using Scratch Wound Assay To Study The Effect Of Soil Arsenic On Human Dermal Fibroblasts Cell Migration Due To Contact Exposure, Manas Warke, Laura De Marchi, Srinivas Kannan, Madeline English, Rohan Sarkar, Rupali Datta, Smitha Rao
Michigan Tech Research Data
The scratch wound assay was performed on Normal Human Primary Dermal Fibroblasts (HDFa) cells to observe the effect on cell migration due to contact exposure to arsenic-contaminated Immokalee soil. The cell migration was observed through a microscope for 72 h. HDFa cells were seeded in 48-well plate. On day 3, treatment media was added (n=8). The cells were treated with four concentrations of soil As (45, 225, 450, and 900 mg/kg) and two controls - Negative control (NC; Pure media) and control (C; 0 mg/kg soil As) for 72 h. A scratch was made using a pipette tip. The wound …
Novel Nanocomposites For The Treatment Of Lung Infections, Uday Kumar Chintapula
Novel Nanocomposites For The Treatment Of Lung Infections, Uday Kumar Chintapula
Bioengineering Dissertations
Lung infections, especially lower respiratory tract infections and their associated pneumonias, are one of the leading causes of death, accounting for more than 4 million fatalities every year worldwide. Bacterial pathogens are involved in many lower respiratory tract infections including emerging antibiotic resistant respiratory pathogens such as methicillin-resistant staphylococcus aureus (MRSA). Current interventions for MRSA lung infections include systemic antibiotic treatments for an extended period leading to various side effects such as acute kidney injury, nephrotoxicity, and so on. To overcome these limitations, the goal of this dissertation research is to develop a drug delivery system, which includes pathogen-specific drug-loaded …
Mapping Of Electroencephalogram (Eeg) Responses To Newsvendor Decision Model And Cerebral Hemodynamic Responses To Transcranial Photobiomodulation (Tpbm) In Humans, Cong Dung Nghi Truong
Mapping Of Electroencephalogram (Eeg) Responses To Newsvendor Decision Model And Cerebral Hemodynamic Responses To Transcranial Photobiomodulation (Tpbm) In Humans, Cong Dung Nghi Truong
Bioengineering Dissertations
Decision-making is one of the most critical activities of human beings. Various studies have investigated the brain responses to a variety of decision tasks by deploying the EEG data. The first aim of my dissertation was to investigate the neurocognitive mechanisms and correlations across multiple subjects when people make risky economic decisions. A decision-making task was designed based on the newsvendor problem (NP) with two scenarios: low-profit margins (LM) as the more challenging scenario and high-profit margins (HM) as the less difficult one. The EEG signals were acquired from healthy humans while subjects were performing the task. The Correlated Component …
Development Of Algorithms To Analyze Electrogastrography (Egg) For Neonatal Gastrointestinal Development And Electroencephalography (Eeg) For Effects Of Led-Based Pre-Frontal Light Stimulation, Akhil Mahendra M Chaudhari
Development Of Algorithms To Analyze Electrogastrography (Egg) For Neonatal Gastrointestinal Development And Electroencephalography (Eeg) For Effects Of Led-Based Pre-Frontal Light Stimulation, Akhil Mahendra M Chaudhari
Bioengineering Dissertations
Algorithm development, and biological signal processing are the key components for new applications of successful medical diagnosis that can provide physiological and functional information to better understand human condition for either patients with certain diseases or healthy human beings. Neuroimaging tools, such as functional near infrared spectroscopy (fNIRS), and electrogastrography (EGG) have been used to investigate the gut maturity in diseased and healthy state; and electroencephalogram (EEG) have been used to investigate brain functions in response to neuromodulated or task-based interventions. Accordingly, my dissertation focused on algorithm development and signal processing for two major topics: (1) to outline EGG response …
Engineering Enzymatic Pathways In The Gut Microbiome To Control Dietary Isoflavone Metabolism, Lenaiya Allisen Kydd
Engineering Enzymatic Pathways In The Gut Microbiome To Control Dietary Isoflavone Metabolism, Lenaiya Allisen Kydd
Bioengineering Dissertations
ABSTRACT: Observing how plasmids persist within the gut can help us understand how newly introduced genes are transmitted within the gut microbiome. I sought to determine the persistence of genetic constructs introduced to the murine gut and then develop our own genetic system to be delivered to the gut to engineer the microbiome in its ability to convert certain dietary isoflavones. In my initial experiments, mice were given bacteria containing a genetically engineered plasmid and were examined for the persistence of the plasmid in the gut. I found long-term persistence of the plasmid in the gut for up to 2 …