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Zebrafish: An In Vivo Model For The Study Of Human Diseases, Bibhas Kar, Sivamani Subbiah
Zebrafish: An In Vivo Model For The Study Of Human Diseases, Bibhas Kar, Sivamani Subbiah
Emily Scott
The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology, being well suited to both developmental and genetic analysis. More recently, the rapid progress of various zebrafish genomics infrastructure initiatives is facilitating the development of zebrafish models of human disease. Genome organization and the pathways involved into control of signal transduction appear to be highly conserved between zebrafish and humans and therefore zebrafish may be used for modeling of human diseases. This review will highlight and describe the utility of zebrafish in the study of human diseases.
Autism As The Early Closure Of A Neuroplastic Critical Period Normally Seen In Adolescence, Julia Marie Berger, Troy T. Rohn, Julia Thom Oxford
Autism As The Early Closure Of A Neuroplastic Critical Period Normally Seen In Adolescence, Julia Marie Berger, Troy T. Rohn, Julia Thom Oxford
Biology Faculty Publications and Presentations
The most severe cases of autism are diagnosed by extreme social dysfunction and other behavioral abnormalities. A number of genetic studies have been conducted to correlate behavioral phenotypes to genetic dysfunctions, but no “autism gene” has yet been discovered. In addition, environmental factors have been found to influence the development of autistic traits with high probability. This review will examine the role of a shortened period of neuroplasticity as a unifying feature of the autistic phenotype. The neuroplastic period of interest normally extends into adolescence, allowing for neural integration and the development of language and social skills. Early closure of …
Confocal Microscopy Study Of The Embryonic Development Of The Viviparous Nemertean Prosorhochmus Americanus Reveals Larval Features Supporting Indirect Development In Hoplonemerteans, S Tyler Spindle
Theses and Dissertations
Recent studies of hoplonenemertean planuliform larvae have clarified their development and provided insight into larval evolution within the phylum. However, an assessment of viviparous development using modern techniques is lacking. To help facilitate a comprehensive comparative evaluation of developmental diversity within hoplonemerteans, we have conducted a confocal laser scanning microscopy investigation of the development in Prosorhochmus americanus, one of the few viviparous hoplonemertean species. Phalloidin staining provides evidence of a modified transitory larval epidermis, and reveals that the foregut, midgut, proboscis, central nervous system, and body wall musculature form early in development, consistent with observations for planktonic and encapsulated hoplonemertean …
The Importance Of Epigenetic Phenomena In Regulating Activity Of The Genetic Material, Sin Chan
The Importance Of Epigenetic Phenomena In Regulating Activity Of The Genetic Material, Sin Chan
Senior Honors Projects
Genetics has taught us that genes are represented as discrete sequences within a larger DNA molecule found embedded within the chromosomes of a living cell. Collectively these chromosomes and their associated genes carry all of the instructions for life. Until recently, the prevailing thought has been that genes are destiny in the life of an individual since the genes carry the information that determines the general traits and characteristics associated with that individual. The relatively recent understanding of mechanisms that underlie epigenetic phenomena has led to a rethinking of this concept. Epigenetics describes cellular mechanisms that explain how two individuals …
Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton
Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton
UNLV Theses, Dissertations, Professional Papers, and Capstones
Schizophrenia is a debilitating mental disorder that affects up to 3% of the world population. The behavioral symptoms are categorized into positive and negative symptoms, which appear during late adolescence/early adulthood. Unfortunately, the underlying cellular and molecular mechanisms of the disease are poorly understood. Several hypotheses exist to explain mechanisms contributing to these behavioral alterations. One model proposes that a reduced function of the NMDA glutamate receptor on specific GABAergic interneurons may be responsible for deficits in schizophrenia. Post-mortem investigations provide evidence of reductions in both glutamate and GABA-related proteins in patients with schizophrenia. Further, GABAergic interneurons that are activated …
Effects Of Experimentally Elevated Traffic Noise On Nestling White-Crowned Sparrow Stress Physiology, Immune Function And Life History, Ondi L. Crino, Erin E. Johnson, Jessica L. Blickley, Gail L. Patricelli, Creagh W. Breuner
Effects Of Experimentally Elevated Traffic Noise On Nestling White-Crowned Sparrow Stress Physiology, Immune Function And Life History, Ondi L. Crino, Erin E. Johnson, Jessica L. Blickley, Gail L. Patricelli, Creagh W. Breuner
Biological Sciences Faculty Publications
Roads have been associated with behavioral and physiological changes in wildlife. In birds, roads decrease reproductive success and biodiversity and increase physiological stress. Although the consequences of roads on individuals and communities have been well described, the mechanisms through which roads affect birds remain largely unexplored. Here, we examine one mechanism through which roads could affect birds: traffic noise. We exposed nestling mountain white-crowned sparrows (Zonotrichia leucophrys oriantha) to experimentally elevated traffic noise for 5 days during the nestling period. Following exposure to traffic noise we measured nestling stress physiology, immune function, body size, condition and survival. Based …
The Pea Aphid Uses A Version Of The Terminal System During Oviparous, But Not Viviparous, Development, Ryan D. Bickel, Hillary C. Cleveland, Joanna Barkas, Caitlin C. Jeschke, Amelie A. Raz, David L. Stern, Gregory K. Davis
The Pea Aphid Uses A Version Of The Terminal System During Oviparous, But Not Viviparous, Development, Ryan D. Bickel, Hillary C. Cleveland, Joanna Barkas, Caitlin C. Jeschke, Amelie A. Raz, David L. Stern, Gregory K. Davis
Biology Faculty Research and Scholarship
Background: In most species of aphid, female nymphs develop into either sexual or asexual adults depending on the length of the photoperiod to which their mothers were exposed. The progeny of these sexual and asexual females, in turn, develop in dramatically different ways. The fertilized oocytes of sexual females begin embryogenesis after being deposited on leaves (oviparous development) while the oocytes of asexual females complete embryogenesis within the mother (viviparous development). Compared with oviparous development, viviparous development involves a smaller transient oocyte surrounded by fewer somatic epithelial cells and a smaller early embryo that comprises fewer cells. To investigate …