Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Generating Crispr Mutations In The Asymmetric Leaves1 Gene Of Arabidopsis, Gabriella J. Rueschhoff, Tara Phelps-Durr
Generating Crispr Mutations In The Asymmetric Leaves1 Gene Of Arabidopsis, Gabriella J. Rueschhoff, Tara Phelps-Durr
SACAD: John Heinrichs Scholarly and Creative Activity Days
The goal of this study is to create new mutations in the ASYMMETRIC LEAVES 1 (AS1) gene of Arabidopsis using CRISPR technology. AS1 is a myb domain transcription factor that represses the KNOX genes, a group of genes involved in maintaining an undifferentiated cell state. AS1 binds to the chromatin remodeling protein Histone Repressor A (HIRA). In animals, HIRA is involved in the permanent suppression of proliferation genes required for early development. The interaction between AS1 and HIRA provides clues to how AS1 maintains suppression at the KNOX genes; however, we must be careful applying what …