Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Cognitive And Web Phenotypes Of The Western Black Widow Spider, Clint Michael Sergi
Cognitive And Web Phenotypes Of The Western Black Widow Spider, Clint Michael Sergi
Theses and Dissertations
Animals with brains create mental representations of their environment and their own position within it, and use these representations to make decisions. The information used to create mental representations, and how animals use representations to make decisions, are functions of an animal’s evolution and ecology. Mental representations can be as simple as remembering the direction and distance home, or as detailed as a human’s mental map of their own home. I used behavior assays designed to reveal the contents of mental representations to investigate how a web spider creates representation of its environment and objects within it, and uses these …
The Role Of A Camkii/Pka-Protein Degradation-Glur2 Pathway In The Control Of Memory Updating Following Retrieval, Timothy Jarome
The Role Of A Camkii/Pka-Protein Degradation-Glur2 Pathway In The Control Of Memory Updating Following Retrieval, Timothy Jarome
Theses and Dissertations
Reconsolidation is thought to be a process whereby consolidated memories can be modified following retrieval. However, very little is known about the molecular mechanisms that regulate this reconsolidation process. In the present series of experiments we tested if memories "destabilize" or become labile following retrieval through a specific signaling pathway. We found that retrieval of a contextual fear memory differentially increased proteasome activity in the amygdala and hippocampus and resulted in unique changes in AMPA receptor subunit expression in these brain regions. These changes were dependent on CaMKII activity, which was required for increases in Rpt6-S120 phosphorylation, proteasome activity and …