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A Histopathological Study Of The Effect Of Ethylnitrosourea On Ha(Icr) Mice Testes, Mildred Rodriguez

Masters Theses

Ethylnitrosourea (ENU) is very strongly mutagenic, carcinogenic and teratogenic in mice. In the present study ENU was used to induce germ cell damage in the mouse testis. Mice were given single injections of vehicle, 50, 100, or 200 milligrams of ENU per kilogram of body weight and killed at various times over a fifteen week period. Microscopic examination of the testes showed that extensive killing of spermatogonial cells and therefore maturation depletion had occurred in the seminiferous tubules. The histopathology was dose dependent and the testicular weight decreased with an increasing ENU concentration.

Glycosaminoglycans Of Normal And Diabetic Human Plasma, Gloria Badiner

Masters Theses

Diabetic complications in nnn-insulin dependent tissues have led < researchers to investigate causitive parameters at the biochemical level. The purpose of this project was to measure glycosaminoglycans in diabetic and normal human plasma and to investigate any changes in glycosaminoglycan content for possible roles in diabetic complications.

Glycosaminoglycan content was measured by three methods; the alcian blue assay, protein-bound hexosamine, and total glycosaminoglycan isolate methods. Results show IDDM plasma to have significantly increased levels of glycosaminoglycans as assayed by the alcian blue test and protein-bound hexosamine. The total glycosaminoglycan isolate method did not correlate with either of the two other methods. No difference was demonstrated between normal and NIDDM plasma glycosamino glycan content.

The protein-bound hexosamine and the alcian blue assays correlate with age and type of diabetes. No differences between the sexes were demonstrated. Of particular interest are …

Seasonal Movements Of White-Tailed Deer In East-Central Illinois, James E. Chelsvig

Masters Theses

No abstract provided.