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Cop9 Signalosome Promotes Neointimal Hyperplasia Via Deneddyaltion And Csn5-Mediated Nuclear Export, Samiksha Giri
Cop9 Signalosome Promotes Neointimal Hyperplasia Via Deneddyaltion And Csn5-Mediated Nuclear Export, Samiksha Giri
Dissertations and Theses
Neointimal hyperplasia (NH) is a common pathological response to vascular injury and mediated primarily by vascular smooth muscle cell (VSMC) migration and proliferation. The COP9 signalosome (CSN) is formed by 8 canonical subunits (CSN1 through CSN8) with its deneddylation activity residing in CSN5. Each or some of CSN subunits may have deneddylation-independent function but this is not well established. Despite the CSN being known to be a key regulator of protein degradation, its role in vascular biology remains obscure. The present study was conducted to fill these critical gaps.Our immunohistochemistry analyses revealed substantially higher CSN5 levels in the neointimal VSMCs …