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Enhancers Of Gzp1, A Gene Required For Cell-Signaling In Caenorhabditis Elegans, Define A Set Of Genes Required For Germline Development, Li Qiao, James L. Lissemore, Pei Shu, Anne Smardon, Melanie B. Gelber, Eleanor M. Maine
Enhancers Of Gzp1, A Gene Required For Cell-Signaling In Caenorhabditis Elegans, Define A Set Of Genes Required For Germline Development, Li Qiao, James L. Lissemore, Pei Shu, Anne Smardon, Melanie B. Gelber, Eleanor M. Maine
Biology - All Scholarship
The distal tip cell (DTC) regulates the proliferation or differentiation choice in the Cmorhabditis ekgans germline by an inductive mechanism. Cell signaling requires a putative receptor in the germline, encoded by the glp-1 gene, and a putative signal from the DTC, encoded by the lag-2 gene. Both glp-1 and lag-2 belong to multigene gene families whose members are essential for cell signaling during development of various tissues in insects and vertebrates as well as C. elegans. Relatively little is known about how these pathways regulate cell fate choice. To identify additional genes involved in the glp-1 signaling pathway, we carried …