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Articles 1 - 12 of 12
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Mesenchymal Stem Cells In The Treatment Of Osteogenesis Imperfecta, Erica Lang, Julie A. Semon
Mesenchymal Stem Cells In The Treatment Of Osteogenesis Imperfecta, Erica Lang, Julie A. Semon
Biological Sciences Faculty Research & Creative Works
Osteogenesis Imperfecta (OI) is a Disease Caused by Mutations in Different Genes Resulting in Mild, Severe, or Lethal Forms. with No Cure, Researchers Have Investigated the Use of Cell Therapy to Correct the Underlying Molecular Defects of OI. Mesenchymal Stem Cells (MSCs) Are of Particular Interest Because of their Differentiation Capacity, Immunomodulatory Effects, and their Ability to Migrate to Sites of Damage. MSCs Can Be Isolated from Different Sources, Expanded in Culture, and Have Been Shown to Be Safe in Numerous Clinical Applications. This Review Summarizes the Preclinical and Clinical Studies of MSCs in the Treatment of OI. Altogether, the …
Variable Rates Of Hybridization Among Contact Zones Between A Pair Of Topminnow Species, Fundulus Notatus And F. Olivaceus, David D. Duvernell, Naznin S. Remex, Jeffrey T. Miller, Jacob F. Schaefer
Variable Rates Of Hybridization Among Contact Zones Between A Pair Of Topminnow Species, Fundulus Notatus And F. Olivaceus, David D. Duvernell, Naznin S. Remex, Jeffrey T. Miller, Jacob F. Schaefer
Biological Sciences Faculty Research & Creative Works
Pairs of species that exhibit broadly overlapping distributions, and multiple geographically isolated contact zones, provide opportunities to investigate the mechanisms of reproductive isolation. Such naturally replicated systems have demonstrated that hybridization rates can vary substantially among populations, raising important questions about the genetic basis of reproductive isolation. The topminnows, Fundulus notatus and F. olivaceus, are reciprocally monophyletic, and co-occur in drainages throughout much of the central and southern United States. Hybridization rates vary substantially among populations in isolated drainage systems. We employed genome-wide sampling to investigate geographic variation in hybridization, and to assess the possible importance of chromosome fusions to …
Best Practices To Promote Field Science Safety, Kristen Yarincik, Anne Kelly, Terry Mcglynn, Robin M. Verble
Best Practices To Promote Field Science Safety, Kristen Yarincik, Anne Kelly, Terry Mcglynn, Robin M. Verble
Biological Sciences Faculty Research & Creative Works
Interventions are necessary to address the ongoing epidemic of sexual harassment and assault in field settings. An evidence-based approach to identifying specific interventions will be most effective at promoting the safety of scientists. We present the results of a workshop conducted by experts in field biology and the study of sexual harassment and assault that identified a comprehensive set of best practices for individuals and organizations. These recommendations are grounded in peer-reviewed scholarship and are separated into four topics: culture change, accountability, policy development, and reporting. The resulting report of the workshop recommends 44 practices, categorized by the resources required …
Beyond A Vision For The Future: Tangible Steps To Engage Diverse Participants In Inclusive Field Experiences, Robin M. Verble, Corinne L. Richards-Zawacki, Vanessa K.H. Young
Beyond A Vision For The Future: Tangible Steps To Engage Diverse Participants In Inclusive Field Experiences, Robin M. Verble, Corinne L. Richards-Zawacki, Vanessa K.H. Young
Biological Sciences Faculty Research & Creative Works
Synopsis Recent strides toward improving diversity, equity, and inclusion (DEI) in field biology present a unique opportunity for transdisciplinary exploration of the impacts and state of a topic that has remained hereto largely underexplored and under-discussed in the academic setting. Within current literature, themes of racial and gender inequity, power imbalances, unsafe environments, and underdeveloped infrastructure and resources are widespread. Thus, we organized a symposium that addressed these compelling issues in field biology DEI through a multitude of experiential and academic lenses. This article will orient the reader to the special issue and offer summative goals and outcomes of the …
Cell-Penetrating Peptides For Use In Development Of Transgenic Plants, Betty Revon Liu, Chi Wei Chen, Yue-Wern Huang, Han Jung Lee
Cell-Penetrating Peptides For Use In Development Of Transgenic Plants, Betty Revon Liu, Chi Wei Chen, Yue-Wern Huang, Han Jung Lee
Biological Sciences Faculty Research & Creative Works
Genetically Modified Plants and Crops Can Contribute to Remarkable Increase in Global Food Supply, with Improved Yield and Resistance to Plant Diseases or Insect Pests. the Development of Biotechnology Introducing Exogenous Nucleic Acids in Transgenic Plants is Important for Plant Health Management. Different Genetic Engineering Methods for DNA Delivery, Such as Biolistic Methods, Agrobacterium Tumefaciens-Mediated Transformation, and Other Physicochemical Methods Have Been Developed to Improve Translocation Across the Plasma Membrane and Cell Wall in Plants. Recently, the Peptide-Based Gene Delivery System, Mediated by Cell-Penetrating Peptides (CPPs), Has Been Regarded as a Promising Non-Viral Tool for Efficient and Stable Gene Transfection …
Scale-Dependent Spatial Ecology Of Paleotropical Leaf Litter Ants (Hymenoptera: Formicidae), Lillian Germeroth, Theodore Sumnicht, Robin M. Verble
Scale-Dependent Spatial Ecology Of Paleotropical Leaf Litter Ants (Hymenoptera: Formicidae), Lillian Germeroth, Theodore Sumnicht, Robin M. Verble
Biological Sciences Faculty Research & Creative Works
The Grain for Which an Observer Conducts a Study is an Important Determinant of its Outcome. Studies of Ants Have Considered Spatial Grains Spanning from Single Meters to Entire Forest Ecosystems and Found Patterns Related to Nutrient Availability, Leaf Litter Depth, Disturbance, and Forest Composition. Here, We Examine a Bornean Leaf Litter Ant Community at Small (1–4 M) and Large (50–250 M) Spatial Scales and Consider the Differences in Community Structure using Structured 1 M2 Quadrats Sampled Via Leaf Litter Sifting and Berlese Extraction. We Found that Small-Scale Patterns in Ant Abundance and Richness Did Not Spatially Auto correlate within …
Link Between Energy Investment In Biosynthesis And Proteostasis: Testing The Cost–Quality Hypothesis In Insects, Taiwo Iromini, Xiaolong Tang, Kyara N. Holloway, Chen Hou
Link Between Energy Investment In Biosynthesis And Proteostasis: Testing The Cost–Quality Hypothesis In Insects, Taiwo Iromini, Xiaolong Tang, Kyara N. Holloway, Chen Hou
Biological Sciences Faculty Research & Creative Works
The Energy Requirement for Biosynthesis Plays an Important Role in an Organism's Life History, as It Determines Growth Rate, and Tradeoffs with the Investment in Somatic Maintenance. This Energetic Trait is Different between Painted Lady (Vanessa Cardui) and Turkestan Cockroach (Blatta Lateralis) Due to the Different Life Histories. Butterfly Caterpillars (Holometabolous) Grow 30-Fold Faster, and the Energy Cost of Biosynthesis is 20 Times Cheaper, Compared to Cockroach Nymphs (Hemimetabolous). We Hypothesize that Physiologically the Difference in the Energy Cost is Partially Attributed to the Differences in Protein Retention and Turnover Rate: Species with Higher Energy Cost May Have a Lower …
Gender, Sexual Orientation, Ethnicity And Socioeconomic Factors Influence How Wildland Firefighters Communicate Their Work Experiences, Miranda Ragland, Jennifer Harrell, Molly Ripper, Seth Pearson, Rachel Granberg, Robin M. Verble
Gender, Sexual Orientation, Ethnicity And Socioeconomic Factors Influence How Wildland Firefighters Communicate Their Work Experiences, Miranda Ragland, Jennifer Harrell, Molly Ripper, Seth Pearson, Rachel Granberg, Robin M. Verble
Biological Sciences Faculty Research & Creative Works
As Climates Change, Natural Resource Professionals Are Often Working on the Frontlines of Intensifying Environmental Disasters, Acting in Both Scientific and Emergency Response Roles. One Subset of This Group, Wildland Firefighters Often Engage in Multifaceted Careers that Incorporate Elements of Resource Planning, Conservation Management, Community Disaster Relief, and Operational Management. Despite These STEM Roles and Nearly Half (48%) of Them Having Earned at Least a bachelor's degree, usually in a STEM Field, Wildland Firefighters Are Almost Exclusively Lumped with Emergency Responders in the Scientific Literature. We Surveyed 708 Wildland Firefighters with 9 Open Response Questions as Part of a Larger …
Variability Of Hybridization In Topminnows, David D. Duvernell
Variability Of Hybridization In Topminnows, David D. Duvernell
Biological Sciences Faculty Research & Creative Works
Pairs of species that exhibit broadly overlapping distributions, and multiple geographically isolated contact zones, provide opportunities to investigate the mechanisms of reproductive isolation. Such naturally replicated systems have demonstrated that hybridization rates can vary substantially among populations, raising important questions about the genetic basis of reproductive isolation. The topminnows, Fundulus notatus and F. olivaceus, are reciprocally monophyletic, and co-occur in drainages throughout much of the central and southern United States. Hybridization rates vary substantially among populations in isolated drainage systems. We employed genome-wide sampling to investigate geographic variation in hybridization, and to assess the possible importance of chromosome fusions …
White Matter Hyperintensity Longitudinal Morphometric Analysis In Association With Alzheimer Disease, Jeremy Fuller Strain, Chia Ling Phuah, Babatunde Adeyemo, Kathleen Cheng, Kyle B. Womack, John Mccarthy, Manu Goyal, Yasheng Chen, Aristeidis Sotiras, Hongyu An, Chengjie Xiong, Andrea Scharf, Catherine Newsom-Stewart, John Carl Morris
White Matter Hyperintensity Longitudinal Morphometric Analysis In Association With Alzheimer Disease, Jeremy Fuller Strain, Chia Ling Phuah, Babatunde Adeyemo, Kathleen Cheng, Kyle B. Womack, John Mccarthy, Manu Goyal, Yasheng Chen, Aristeidis Sotiras, Hongyu An, Chengjie Xiong, Andrea Scharf, Catherine Newsom-Stewart, John Carl Morris
Biological Sciences Faculty Research & Creative Works
INTRODUCTION: Vascular damage in Alzheimer's disease (AD) has shown conflicting findings particularly when analyzing longitudinal data. We introduce white matter hyperintensity (WMH) longitudinal morphometric analysis (WLMA) that quantifies WMH expansion as the distance from lesion voxels to a region of interest boundary. METHODS: WMH segmentation maps were derived from 270 longitudinal fluid-attenuated inversion recovery (FLAIR) ADNI images. WLMA was performed on five data driven WMH patterns with distinct spatial distributions. Amyloid accumulation was evaluated with WMH expansion across the five WMH patterns. RESULTS: The preclinical group had significantly greater expansion in the posterior ventricular WM compared to controls. Amyloid significantly …
Study Of Legionella Pneumophila Treatment With Copper In Drinking Water By Single Cell-Icp-Ms, Lei Xu, Austin Sigler, Anna Chernatynskaya, Lindsey Rasmussen, Jingrang Lu, Endalkachew Sahle-Demessie, David J. Westenberg, Hu Yang, Honglan Shi
Study Of Legionella Pneumophila Treatment With Copper In Drinking Water By Single Cell-Icp-Ms, Lei Xu, Austin Sigler, Anna Chernatynskaya, Lindsey Rasmussen, Jingrang Lu, Endalkachew Sahle-Demessie, David J. Westenberg, Hu Yang, Honglan Shi
Biological Sciences Faculty Research & Creative Works
Legionella pneumophila is a persistent opportunistic pathogen that poses a significant threat to domestic water systems. Previous studies suggest that copper (Cu) is an effective antimicrobial in water systems. A rapid and sensitive quantification method is desired to optimize the conditions of L. pneumophila treatment by Cu and to better understand the interaction mechanisms between Cu and cells. In this study, we developed a highly sensitive single cell (SC)-ICP-MS method to monitor L. pneumophila cell concentration and track their uptake of Cu. The SC-ICP-MS method showed excellent sensitivity (with a cell concentration detection limit of 1000 cells/mL), accuracy (good agreement …
3d-Printed Hydrogels Dressings With Bioactive Borate Glass For Continuous Hydration And Treatment Of Second-Degree Burns, Fateme Fayyazbakhsh, Michael J. Khayat, Candy Sadler, Delbert Day, Yue-Wern Huang, Ming-Chuan Leu
3d-Printed Hydrogels Dressings With Bioactive Borate Glass For Continuous Hydration And Treatment Of Second-Degree Burns, Fateme Fayyazbakhsh, Michael J. Khayat, Candy Sadler, Delbert Day, Yue-Wern Huang, Ming-Chuan Leu
Biological Sciences Faculty Research & Creative Works
Recent advances in additive manufacturing have led to the development of innovative solutions for tissue regeneration. Hydrogel materials have gained significant attention for burn wound treatment in clinical practice among various advanced dressings due to their soothing and moisturizing activity. However, prolonged healing, pain, and traumatic removal due to the lack of long-term wound hydration are some of the challenges in the treatment of second-degree burn wounds. In this study, 3D-printed dressings were fabricated using gelatin, alginate, and bioactive borate glass (BBG) using an extrusion-based bioprinter. After ionic crosslinking, the 3D-printed dressings were characterized for mechanical properties, degradation rate, hydration …