Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Entire DC Network
Novel Insights Into The Contribution Of Cellular Senescence To Cancer Therapy: Reversibility, Dormancy And Senolysis., Tareq Saleh
Novel Insights Into The Contribution Of Cellular Senescence To Cancer Therapy: Reversibility, Dormancy And Senolysis., Tareq Saleh
Theses and Dissertations
Cellular senescence a specialized form of growth arrest that contributes to the pathogenesis of several aging-related disorders including cancer. While by definition tumor cells are considered immortalized, they can undergo senescence when exposed to conventional and targeted cancer therapy. Therapy-Induced Senescence (TIS) represents a fundamental response to therapy and impacts its outcomes. However, TIS has been considered a positive therapeutic goal since senescent tumor cells are expected to enter a state of permanent growth abrogation. In this work we examined the hypothesis that a subpopulation of senescent cells can re-acquire proliferative potential after a state of senescent dormancy, indicating that …
Changes In Leaf Morphology, Photosynthesis And Nitrogen Content In Two Coastal Shrubs, Elizabeth Kost
Changes In Leaf Morphology, Photosynthesis And Nitrogen Content In Two Coastal Shrubs, Elizabeth Kost
Theses and Dissertations
It is important to understand mechanisms that facilitate expansion of two common shrubs, Morella cerifera and Baccharis halimifolia in coastal environments. The purpose of my study was to investigate the physiological and structural changes that occur as leaves age. Photosynthesis, incident light, chlorophyll, and leaf C:N ratios were quantified for young, intermediate, and old leaves (distal, central and proximal leaves, respectively). Leaf structural differences were also compared. Leaves did not change morphologically with age. Light decreased with leaf age and during winter months. Photosynthesis showed no seasonal or age related patterns. Chlorophyll increased initially and then declined with age due …
The Role Of Mitogen-Activated Protein Kinases In The Regulation Of Plant Development, Erica Satterfield
The Role Of Mitogen-Activated Protein Kinases In The Regulation Of Plant Development, Erica Satterfield
Theses and Dissertations
Mitogen-activated protein kinases are part of an evolutionarily conserved protein phosphorylation cascade which serves essential regulatory functions in eukaryotic organisms. Although the role of MAPKs in the regulation of a plant’s response to environmental stress and plant defense has been well established, very little is known about their role in the regulation of plant developmental processes. In order to examine the role of MAPKs in plant growth and development, a strong mammalian MAPK phosphatase (MKP-1), which is known to inactivate MAPKs in plants, was introduced into tobacco plants. In tobacco plants, MKP-1 overexpression altered plant responses to the phytohormones, ethylene …