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Bacteriophage Host-Range Expansion To Include Two Strains Of Clostridium Sporogenes, Kevin Crown Dec 2014

Bacteriophage Host-Range Expansion To Include Two Strains Of Clostridium Sporogenes, Kevin Crown

Biology ETDs

Bacteriophages are viruses that infect bacteria, which have been used to treat bacterial infections in people for decades. They are also now being used as FDA approved preservatives as a means to prevent the growth of spoiling bacteria in many ready-to-eat foods. Bacteriophages tend to infect a very narrow range of bacterial hosts, some only a single sub-strain. When used for therapeutics or food treatment however, it is desirable to use phages that are promiscuous in their host range. This has led to attempts to broaden the host range of the most useful phages. By passaging phages in co-cultures of …


Aret: A Novel Regulator Of Alternative Splicing In The Flight Muscle Transcripts In Drosophila Melanogaster, Sandy T. Oas Dec 2014

Aret: A Novel Regulator Of Alternative Splicing In The Flight Muscle Transcripts In Drosophila Melanogaster, Sandy T. Oas

Biology ETDs

Drosophila melanogaster has been used as a model organism for understanding muscle development. Drosophila flight and jump muscles are distinct functionally and biochemically. This distinction is due to differentially expressed genes and differentially spliced mRNA transcripts. The exact mechanism of alternative splicing in somatic muscles is not well characterized. Aret was previously shown to be a transcriptional repressor, and has been implicated in splicing regulation based upon literature analysis and preliminary work. This study aims to define the regulatory role of Aret and the impact of alternative splicing on determining muscle diversification and fiber choice. We indicate the importance of …


Evaluating The Utility Of Natural History Collections In Research And For The Public, Bethany Abrahamson Jul 2014

Evaluating The Utility Of Natural History Collections In Research And For The Public, Bethany Abrahamson

Biology ETDs

Natural history collections (NHCs) are useful in many fields of study, but knowledge about how they are used in the modern day is poor. The first part of this study, focused on the collections data held by the Museum of Southwestern Biology (MSB), analyzes specimen-based publications, specimen loan records, and guestbook information to determine how NHCs have been used in scientific study over time. Using a novel methodology, I objectively sorted the publications into ten research subjects via particular phrases found in publication titles, places of publication, and keywords. I observed from this dataset the proportions of particular subjects for …


Establishment Of Larrea Tridentata At The Northern Edge Of The Modern Mojave Desert: Insights From Neotoma Paleomiddens, Clare Steinberg Jul 2014

Establishment Of Larrea Tridentata At The Northern Edge Of The Modern Mojave Desert: Insights From Neotoma Paleomiddens, Clare Steinberg

Biology ETDs

Shifting climates affect the composition of biological communities. If environmental conditions change sufficiently, new species can invade, leading to large-scale community turnover. Understanding how and why such shifts occur is crucial in this era of anthropogenic global change. Paleontological studies provide a valuable long-term perspective of the dynamics of community turnover. Here, we examine changes in the plant community over the past 34 thousand years in what is now the northern Mojave Desert. This time period includes the last glacial maximum as well as numerous smaller climatic fluctuations in the Holocene and the end of the Pleistocene. We quantified plant …