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The Use Of Mycobacteriophages As A Novel Therapeutic Option To Control And Treat Johne's Disease, Gillian Catherine Crowley
The Use Of Mycobacteriophages As A Novel Therapeutic Option To Control And Treat Johne's Disease, Gillian Catherine Crowley
Theses
The incidences of Johne’s disease (JD) in farms worldwide have increased significantly over the last 80 years. The increase in JD is owing to the lack of diagnostic tests available and the long incubation period of the disease causing pathogen, Mycobacterium avium paratuberculosis (MAP). In addition, treatment of JD with antibiotics has proven difficult due to the emergence of antibiotic resistance MAP strains and the presence of the thick lipid rich mycobacterial cell wall. An alternative diagnostic and treatment method for JD involves the use of mycobacteriophages. As part of this research, individual mycobacteriophages (TM4) and a mycobacteriophage cocktail (LE1 …