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Determining The Relationship Between Aging And Oxidative Stress In A Drosophila Melanogaster P38 Kb Framework, Aleksandra J. Majewski
Determining The Relationship Between Aging And Oxidative Stress In A Drosophila Melanogaster P38 Kb Framework, Aleksandra J. Majewski
Theses and Dissertations
Aging is inevitable for all organisms and can be characterized by degeneration of tissue, adecrease in motor function, and impaired stress response. In humans, it is often accompanied by an increased propensity for age related diseases. While all adults experience biological aging (senescence) not all adults experience age-associated disease. Thus, we claim these are not normal prospects of aging. Although the implications of aging are well understood, the molecular underpinnings for these processes remain elusive. As advances in medical science have been successful at prolonging lifespan, they concurrently extend the amount of time spend in diseased states. If we wish …
A Combinatorial Premotor Neural Code: Transformation Of Sensory Information Into Meaningful Rhythmic Motor Output By A Network Of Heterogeneous Modulatory Neurons, Christopher John Goldsmith
A Combinatorial Premotor Neural Code: Transformation Of Sensory Information Into Meaningful Rhythmic Motor Output By A Network Of Heterogeneous Modulatory Neurons, Christopher John Goldsmith
Theses and Dissertations
The goal of the following research was to investigate the contributions of neural networks in selecting distinct variants of rhythmic motor activity. We used the premotor commissural ganglion (CoG) in the stomatogastric nervous system of the Jonah crab to understand how this network effectively controls the rhythms produced in downstream motor circuits. Prior research determined that individual CoG neurons are necessary to mediate sensory-induced variation in the effected motor patterns. However, single premotor neuron inputs to the STG are not sufficient to recreate the patterns induced by the selective activation of sensory pathways. Thus, it was hypothesized that the CoG-mediated …
Learning And Behavior In Hatchling Trachemys Scripta Exposed To Bisphenol-A During Embryonic Development, Justin E. Dillard
Learning And Behavior In Hatchling Trachemys Scripta Exposed To Bisphenol-A During Embryonic Development, Justin E. Dillard
Theses and Dissertations
Steroids play an integral role in orchestrating embryonic development, and can affect a suite of phenotypic traits, including learning and memory. Endocrine disrupting compounds (EDCs) can mimic the effects of steroids and can affect the same suites of phenotypic traits during embryonic development. Bisphenol-A (BPA) is an EDC that mimics the action of estrogen, and recent work is beginning to implicate BPA in effects on learning and behavior similar to those caused by estrogen treatment studies. Red-eared slider turtles (Trachemys scripta) are a good system to investigate the effects of BPA on learning and behavior, both because the molecular underpinnings …