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Investigations Into The Genomes Of Two Ascomyetes, Jay Wilbur Pyle

Theses and Dissertations

Fusarium verticillioides is a filamentous ascomycete that is both a plant endophyte and pathogen, causing disease during any life stage of the plant. When F. verticillioides grows in maize the fungus can synthesis a number of mycotoxins including the fumonisins, which have been linked with human esophageal cancer and neural tube associated birth defects. In an attempt to control fumonisin production our lab is searching the genome of F. verticillioides for a selfish genetic element known as Spore killer. The plan is simple; we envision creating a bio-control strain capable of harnessing the genetic transmission-distorting properties of Spore killer to …