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Isolation Of Stenotrophomonas Maltophilia Virus Bfi1: A Biofilm Inhibiting Phage, Thomas Edward Moran
Isolation Of Stenotrophomonas Maltophilia Virus Bfi1: A Biofilm Inhibiting Phage, Thomas Edward Moran
College of Science and Health Theses and Dissertations
The bacterium Stenotrophomonas maltophilia is an emerging infectious pathogen of global concern. Due to its drug-resistant nature, there are limited treatment options available. A potential option for combating S. maltophilia infections is phage therapy, the medicinal use of viruses to treat bacterial infections. Stenotrophomonas phage Bfi1 was isolated from a soil sample using S. maltophilia clinical strain S18202. Transmission electron microscopy provided evidence that this phage is a member of the Siphoviridae family. Host range analysis showed that the phage successfully infected and lysed 30% of the S. maltophilia strains tested. Genomic analysis revealed that the phage contains approximately 32.2-56.5 …