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Functional Analysis Of The Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha-1 (Gabra1) Gene During Zebrafish Development., Nayeli Gabriela Reyes-Nava
Functional Analysis Of The Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha-1 (Gabra1) Gene During Zebrafish Development., Nayeli Gabriela Reyes-Nava
Open Access Theses & Dissertations
The GABRA1 gene encodes for the alpha-1 (α1) subunit of the Gamma-Aminobutyric acid type A receptor (GABAAR), which are the primary modulators of synaptic inhibition in the central nervous system (CNS). Alpha-1 subunits are essential for maintaining the normal function of native receptors and contribute to over 60% of all GABAARs in the CNS. Remarkably, a broad spectrum of neurodevelopmental and epilepsy-associated disorders have been linked with mutations in the GABRA1 gene. However, the developmental, behavioral, and molecular mechanisms underlying GABRA1-associated epileptic disorders remain to be fully understood. Hence, the overarching goal of this dissertation is to investigate the behavioral …
Region-Specific Modifications Of Synaptic Proteins In Response To Early-Life Adversity In The Rat Brain, Jameel Nasser Hamdan
Region-Specific Modifications Of Synaptic Proteins In Response To Early-Life Adversity In The Rat Brain, Jameel Nasser Hamdan
Open Access Theses & Dissertations
Drug addiction is a serious condition affecting approximately 19.7 million people in the United States alone (SAMHSA 2018). Exposure to stress and other adverse conditions has been shown to impact drug-taking behavior and making individuals more vulnerable to addiction. In those already suffering from addiction, abstaining from drug use often gives way to relapse after a stressful event (Lu, Shepard et al. 2003; Shaham, Erb et al. 2000). The experience of adversity during early-life can cause long-lasting changes in the brain, affecting development, behavior, learning and memory, and critical thinking processes, which may persist into adulthood (Aisa, Tordera et al. …