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Development And Characterization Of Monoclonal Antibodies Directed Against Tanapox Virus, Michael Franz
Development And Characterization Of Monoclonal Antibodies Directed Against Tanapox Virus, Michael Franz
Masters Theses
The initial symptoms of a Tanapoxvirus (TPV) infection are indistinguishable from smallpox, which is caused by variola virus (VV). In the post-9/11 area, reagents that can quickly differentiate a TPV infection from smallpox are very desirable, but currently unavailable. Monoclonal antibodies (mAbs) directed specifically against TPV can be used for this purpose. Six mAbs were developed and characterized that specifically bind to TPV infected owl monkey kidney (OMK) cells, but not uninfected cells. The apparent molecular mass of the TPV protein(s) recognized by 5 mAbs were calculated using the Western blot technique. One mAb demonstrated no binding using the Western …
Mechanism Of Chromium Reduction Of Benzo[A]Pyrene Diolepoxide Mutagenesis In Human Fibroblasts, Cara Suzanne Kriss
Mechanism Of Chromium Reduction Of Benzo[A]Pyrene Diolepoxide Mutagenesis In Human Fibroblasts, Cara Suzanne Kriss
Masters Theses
Environmental agents can cause an increase in cellular stress and damage DNA which can lead to diseases such as cancer. Chromium produces cellular stress by increasing the reactive oxygen species through a Fenton-like reaction, where chromium reacts with hydrogen peroxide to form hydroxyl radicals. Benzo[ a ]pyrene is an environmental carcinogen that is metabolized by cytochrome p450 enzymes into benzo[a]pyrene diolepoxide (BPDE). BPDE is highly reactive with DNA producing large DNA-adducts primarily on guanine nucleotides. The primary intracellular pathway by which mammalian cells remove damaged DNA caused by bulky mutagens is nucleotide excision repair. We have found that, in BPDE …
Studies On Mycobacterium Ulcerans, Terri Alford
Studies On Mycobacterium Ulcerans, Terri Alford
Masters Theses
Efforts to create a mycolactone-negative mutant of Mycobacterium ulcerans via transposon mutagenesis were undertaken to elucidate the genes involved in the production of this toxin. Though only five PRC-confirmed insertion mutants were produced, one of these, 1615:tnp6w, was confirmed to be deficient in mycolactone production via thin-layer chromatography (TLC) of acetone soluble lipids (ASLs), cytopathicity assay of culture filtrate on L929 fibroblasts, and mass spectroscopy of ASLs. Using nested-PRC, it was determined that the transposon insertion of 1615:tnp6w had occurred in a region of DNA containing a gene 97% identical to the M. marinum ferric uptake regulator homolog (FurA) gene …
Diatom Assemblages Reflect Environmental Heterogeneity In An Urban Stream, Kristen M. Thomas
Diatom Assemblages Reflect Environmental Heterogeneity In An Urban Stream, Kristen M. Thomas
Masters Theses
No abstract provided.
Physiological Performance Of Thamnophis Hammondii Is Not Affected After Eating The Toxic Frog Xenopus Laevis, C. Drew Foster
Physiological Performance Of Thamnophis Hammondii Is Not Affected After Eating The Toxic Frog Xenopus Laevis, C. Drew Foster
Masters Theses
No abstract provided.
Seasonal Use Of An Abandoned Mine And Summer Maternity Roost By Northern Bats (Myotis Septentrionalis), Heather Rae Fraser
Seasonal Use Of An Abandoned Mine And Summer Maternity Roost By Northern Bats (Myotis Septentrionalis), Heather Rae Fraser
Masters Theses
No abstract provided.
Factors Affecting The Mate Guarding Behavior In Japanese Beetles (Popillia Japonica Newman), Yoriko Saeki
Factors Affecting The Mate Guarding Behavior In Japanese Beetles (Popillia Japonica Newman), Yoriko Saeki
Masters Theses
No abstract provided.
Eastern Box Turtle (Terrapene C. Carolina) As A Dispersal Vector Of Seeds And Spores, William J. Jordan
Eastern Box Turtle (Terrapene C. Carolina) As A Dispersal Vector Of Seeds And Spores, William J. Jordan
Masters Theses
No abstract provided.
Changing Turtle Communities Of The Illinois River, Steven J. Paglia
Changing Turtle Communities Of The Illinois River, Steven J. Paglia
Masters Theses
No abstract provided.
Pathogenicity Of Xanthomonas Axonopodis Pv. Glycines, The Causative Agent Of Bacterial Pustule In Soybeans, Lopa D. Goradia
Pathogenicity Of Xanthomonas Axonopodis Pv. Glycines, The Causative Agent Of Bacterial Pustule In Soybeans, Lopa D. Goradia
Masters Theses
No abstract provided.
Impacts Of Agricultural Landscapes On The Breeding Biology And Behavioral Ecology Of Grassland Birds, Susan Allison Linn
Impacts Of Agricultural Landscapes On The Breeding Biology And Behavioral Ecology Of Grassland Birds, Susan Allison Linn
Masters Theses
No abstract provided.
Role Of Demethylation And Hyperacetylation In [Alpha]1-Antitrypsin Gene Activation, Ling Tian
Role Of Demethylation And Hyperacetylation In [Alpha]1-Antitrypsin Gene Activation, Ling Tian
Masters Theses
No abstract provided.