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Investigations Of Filarial Nematode Motility, Response To Drug Treatment, And Pathology, Charles Nutting
Investigations Of Filarial Nematode Motility, Response To Drug Treatment, And Pathology, Charles Nutting
Dissertations
More than a billion people live at risk of chronic diseases caused by parasitic filarial nematodes. These diseases: lymphatic filariasis, onchocerciasis, and loaisis cause significant morbidity, degrading the health, quality of life, and economic productivity of those who suffer from them. Though treatable, there is no cure to rid those infected of adult parasites. The parasites can modulate the immune system and live for 10-15 years. Testing of compounds against filarial nematodes is complicated due to a lack of an objective platform on which to analyze in vitro treatments. There is no published, immunocompetent laboratory model for lymphatic filariasis. This …
Regulation Of Glial Cell Line-Derived Neurotrophic Factor (Gdnf) Production In Voluntary And Involuntary Muscle, John-Mary Vianney
Regulation Of Glial Cell Line-Derived Neurotrophic Factor (Gdnf) Production In Voluntary And Involuntary Muscle, John-Mary Vianney
Dissertations
Glia cell line-derived neurotrophic factor (GDNF) is a survival factor for subpopulations of neurons, including somatic and autonomic motor neurons. These neurons depend, in part, on GDNF that is synthesized and secreted by their target tissues. It has been shown that a number of tissues in the periphery express GDNF and these target tissues differ in their composition, function, and in the case of different muscle cell types, their contractile characteristics. Whether the processes regulating GDNF production in these different tissues is similar or different is poorly understood. The broad goal of this study is to examine factors that normally …