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Emerging Physiological Significance Of R-Type Calcium Currents, Paul Jensen
Emerging Physiological Significance Of R-Type Calcium Currents, Paul Jensen
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R-type channels are voltage dependent calcium channel subtypes. To date, the only variant of the R-type calcium channel that has been isolated and cloned is the Cav2.3 variant, encoded by the gene Cchral (Yamazaki et al., 1998). The channel was named "R-type" because it was initially characterized by its resistance to nifedipine (a blocker of L-type calcium channels), Ω-conotoxin GVIA (an N-type calcium channel blocker) and Ω -Aga IVA (a blocker of P/Q-type calcium channels) (Hille 2001). The Cav2.3 calcium channel is selectively inhibited by the peptide SNX-482, which was isolated from venom of the African …