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Articles 1 - 8 of 8
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Effects Of Benzo[A]Pyrene And Cyp19a1b Knockdown On Zebrafish Development, Khalid M. Alharthy
Effects Of Benzo[A]Pyrene And Cyp19a1b Knockdown On Zebrafish Development, Khalid M. Alharthy
Electronic Theses and Dissertations
Benzo[a]pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis playing a key role in the hypothalamus-pituitary-gonad feedback loop. We hypothesized that BaP would negatively impact cyp19a1b expression in zebrafish, in turn, adversely affecting development and physiology. Here, we consider whether the toxicities observed following BaP exposure are comparable to those following a transient morpholino (MO)-mediated CYP19a1b knockdown or exposure to an aromatase inhibitor (fadrozole) during early development. One-cell zebrafish embryos were injected with a CYP19a1b-MO or control-MO. Other non-injected embryos were exposed to nominal waterborne …
Autoregulation Of The Glial Gene Reversed Polarity In Drosophila Melanogaster, Jamie L. Wood
Autoregulation Of The Glial Gene Reversed Polarity In Drosophila Melanogaster, Jamie L. Wood
Electronic Theses and Dissertations
During development, cells of the nervous system begin as unspecified precursors and proceed along one of two developmental paths to become either neurons or glia. I seek to understand more about the genes that control this process, focusing on the lesser understood of the cell types, glial cells. Using Drosophila melanogaster as a model system, previous work from my lab and others has established the role of the master regulatory transcription factor Gcm in directing neuronal precursor cells to assume a lateral glial fate. Gcm acts on many target genes, one of which is reversed polarity (repo). repo is necessary …
Adaptive Movements And Thermoregulation In Big-Eared Bats, Cody Jordan
Adaptive Movements And Thermoregulation In Big-Eared Bats, Cody Jordan
Electronic Theses and Dissertations
There are a variety of (non-exclusive) reasons to explain the presence of group-living, but clustering or huddling is especially important for small endotherms with high surface-area-to-volume ratios. Clustering is interesting because variations within clustering are seldom investigated despite anecdotal evidence that bat clustering varies widely. I studied a colony of Rafinesque's big-eared bats (Corynorhinus rafinesquii) to learn more about clustering behavior using infrared video. I predicted that temperature would be the primary driver of how and when bats cluster while roosting. The actual relationship was not as predicted by an energetic model. High density clusters of bats were comacross a …
Negative Effects Of Commycorrhizal Networks And Roots On Upland Oak Seedlings In Open-Canopy Woodlands And Closed-Canopy Forests, William Chase Bailey
Negative Effects Of Commycorrhizal Networks And Roots On Upland Oak Seedlings In Open-Canopy Woodlands And Closed-Canopy Forests, William Chase Bailey
Electronic Theses and Dissertations
After extensive logging and fire suppression many oak dominated woodlands or forests are in danger of being replaced by a mix of non-pyrogenic and shade tolerant tree species that benefit from fire suppression. Successful advanced regeneration by oaks in forests and woodlands depends both on the persistence of seedlings in the shade and growth within canopy gaps. Through the sharing of carbon and/or water between adults and seedlings, connection to a commycorrhizal network potentially provides a mechanism by which oak seedlings could persist in shade and/or grow rapidly in dry soils within canopy gaps. A study was conducted to determine …
The Effects Of Clinorotation In The Host Plant, Medicago Truncatula, And Its Microbial Symbionts, Ariel Dauzart
The Effects Of Clinorotation In The Host Plant, Medicago Truncatula, And Its Microbial Symbionts, Ariel Dauzart
Electronic Theses and Dissertations
The aim of this research was to understand mutualistic relationships between plants and endophytic microbes under the influence of an altered gravity vector. Understanding the outcome of the plant-microbe symbiosis in altered gravity is vital to developing life support systems for long distance space travel and colonization of other planets. This research utilized the model tripartite relationship among Medicago truncatula–Sinorhizobium meliloti–Rhizophagus irregularis. Plants were inoculated with rhizobial bacteria (S. meliloti), arbuscular mycorrhizal fungi (R. irregularis), both microbes, or none (microbial control), and placed on a rotating clinostat for 28 d. Vertical and horizontal static controls were also performed. Plant development …
Characterizing The Innate Immunity In The Hawaiian Coral Montipora Capitata, Melinda S. Ansley
Characterizing The Innate Immunity In The Hawaiian Coral Montipora Capitata, Melinda S. Ansley
Electronic Theses and Dissertations
Coral reefs are among the most diverse ecosystems in the world; however, they are quickly diminishing due to natural and anthropogenic stressors, including disease. Corals possess innate immune responses that aid in protection against these stressors. In several coral species, immune responses are inducible in response to stress. Montipora capitata is a predominant coral in Kaneohe Bay, Oahu, Hawaii. This coral occurs in two color morphs, orange and red, and is susceptible to the tissue loss disease Montipora white syndrome (MWS). MWS disease prevalence within Kaneohe Bay varies, with lower prevalence in the North than South Bay and with orange …
Birdie See, Birdie Do: Zebra Finch Observational Learning In Three Cognitive Domains With Discussion Of Cerebellar Involvement, Amy Hribar
Electronic Theses and Dissertations
Observational learning is a cognitive ability that allows individuals to acquire information or skills through watching others. Examples of observational learning can be seen in all major vertebrate groups and some invertebrates. Observational learning may confer a selective advantage to animals due to improvements in decision-making and increased behavioral flexibility. While studies of animals’ observational learning capabilities and the types of information acquired have been examined in many species, multiple types of observational learning have rarely been examined in non-rodent species in controlled laboratory experiments. Additionally, only recently have the neural mechanisms that support observational learning been examined. I sought …
Systems Biology Approach To Understanding The Control Of Glucose Metabolism In Healthy And Apoptotic Neurons, Hoda Gebril
Systems Biology Approach To Understanding The Control Of Glucose Metabolism In Healthy And Apoptotic Neurons, Hoda Gebril
Electronic Theses and Dissertations
Apoptosis plays a crucial role in sculpting the developing central nervous system (CNS) but can, under certain conditions, contribute to neurodegeneration in the mature CNS. Metabolic disturbances have long been associated with apoptosis-inducing agents, however, the mechanism underlying such changes remains controversial. In this study, our hypotheses was that decreased ATP turnover may bring about other metabolic changes in apoptotic neurons. Accordingly, change in metabolic reactions other than ATP turnover may not be important in the study of apoptotic mechanism. In a living cell, metabolic reactions are highly connected and thus are highly sensitive to kinetic change in one or …