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Characterizing The Developmental And Reproductive Toxicities Of Cannabidiol And Δ9-Tetrahydrocannabinol, Dennis Ray Carty Jan 2017

Characterizing The Developmental And Reproductive Toxicities Of Cannabidiol And Δ9-Tetrahydrocannabinol, Dennis Ray Carty

Electronic Theses and Dissertations

Medical marijuana is legal in twenty-nine of the United States and an additional nineteen states have passed legislation for cannabidiol (CBD) treatment of drug-resistant epilepsy, such as Dravet Syndrome (DS) which is diagnosed in children as young as two months. While CBD has shown anecdotal and recently clinical trial efficacy in reducing seizure frequency in DS patients, little is known about the potential adverse side-effects on child physiology, brain development, adult disease, or subsequent generations. Moreover, CBD is rarely administered without including low concentrations of Δ9-tetrahydrocannabinol (THC). The goal of this project is to characterize the relative morphological, behavioral, reproductive, …


Evidence Of Chemical Camouflage In Pirate Perch (Aphredoderus Sayanus); Avoiding Detection By Colonizing/Ovipositing Prey Through Chemical Crypsis, Tyler Breech Jan 2017

Evidence Of Chemical Camouflage In Pirate Perch (Aphredoderus Sayanus); Avoiding Detection By Colonizing/Ovipositing Prey Through Chemical Crypsis, Tyler Breech

Electronic Theses and Dissertations

No abstract provided.


Responses Of The Ocellated Turkey (Meleagris Ocellata) To Human Disturbance, Thomas Hughes Martin Jan 2017

Responses Of The Ocellated Turkey (Meleagris Ocellata) To Human Disturbance, Thomas Hughes Martin

Electronic Theses and Dissertations

Habitat loss and habitat degradation are major drivers of the current biodiversity crisis. Nowhere else are these threats more severe than in the tropics. Because the tropics are estimated to contain as much as 60% of all the species on Earth, they are critically important for the conservation of biodiversity. To conserve species we need to understand both the factors that lead to extinction and how the taxa that persist are able to adapt to the rapid anthropogenic change of their environment. The Ocellated Turkey (Meleagris ocellata) is a Neotropical galliform bird of conservation concern because it faces a rapidly …


Historical Refuges And Recolonization Routes In The Southern Appalachian Mountains, Inferred Through Phylogeographic Analysis Of The Spotted Wintergreen (Chimaphila Maculata), John Daniel Banusiewicz Jan 2017

Historical Refuges And Recolonization Routes In The Southern Appalachian Mountains, Inferred Through Phylogeographic Analysis Of The Spotted Wintergreen (Chimaphila Maculata), John Daniel Banusiewicz

Electronic Theses and Dissertations

Phylogeography has recently benefited from incorporation of coalescent modeling to test competing scenarios of population history of a species. Ecological niche modeling has also been useful in inferring areas of likely suitable habitat during past climate conditions. Several studies have examined the population history of biota in the Southern Appalachian Mountains and how they responded to climate change associated with the end of the Last Glacial Maximum (~18,000 years ago), though few studies have focused on understory plants. This study redressed that knowledge gap thorough examination of the phylogeographic history of the understory plant Chimaphila maculata, which is native to …


Conditions Responsible For The Success Of Carnivorous Plants In Nutrient-Poor Wetlands, Matthew John Abbott Jan 2017

Conditions Responsible For The Success Of Carnivorous Plants In Nutrient-Poor Wetlands, Matthew John Abbott

Electronic Theses and Dissertations

Despite the vast array of past research focused on carnivorous plants, few studies have investigated the ecological interactions between carnivorous and non-carnivorous plant species. I addressed the following three questions: (1) does niche complementarity promote coexistence between fire-adapted carnivorous and non-carnivorous species? (2) do carnivorous plants rely on both leaf traps and arbuscular mycorrhizal fungi to access different nutrients that are in high demand after fire in nutrient poor bogs? (3) why are carnivorous plants largely absent from nutrient-rich wetlands? I addressed the first question by examining the three-way interacting effects of fire, prey-derived nutrient availability, and root competition from …


The Effect Of Road Crossings On Stream-Associated Salamanders Within Holly Springs National Forest, Caleb Ashton Aldridge Jan 2017

The Effect Of Road Crossings On Stream-Associated Salamanders Within Holly Springs National Forest, Caleb Ashton Aldridge

Electronic Theses and Dissertations

Road crossings have significant effects on wildlife, but there is limited information on how road crossings affect stream-associated salamanders. Stream-associated salamanders are vital to their ecological communities and are likely to experience the effect of roads more readily than other species due to their physiological characteristics. To test the effects of road crossings on stream-associated salamanders, I surveyed 12 pairs of confluent streams – one stream crossed by a road and the other not in each pair – within Holly Springs National Forest, Mississippi. Surveys in the summer of 2015 were used to measure abundance and species richness of stream-associated …


The Impact Of Simulated Microgravity On The Growth Of The Model Legume Plant Medicago Truncatula, Gemma Elizabeth Lionheart Jan 2017

The Impact Of Simulated Microgravity On The Growth Of The Model Legume Plant Medicago Truncatula, Gemma Elizabeth Lionheart

Electronic Theses and Dissertations

Simulated microgravity has been a useful tool to help understand plant development in altered gravity conditions. Thirty-one genotypes of the legume plant Medicago truncatula were grown in either simulated microgravity on a rotating clinostat, or a static, vertical environment. Twenty morphological features were measured and compared between these two gravity treatments. Within-species genotypic variation was a significant predictor of the phenotypic response to gravity treatment in 100% of the measured morphological and growth features. In addition, there was a genotype–environment interaction (G×E) for 45% of the response variables, including shoot relative growth rate (p < 0.0005), median number of roots (p ∼ 0.02), and root dry mass (p < 0.005). These findings are discussed in the context of improving future studies in plants space biology by controlling for genotypic differences, and by connecting traits to their underlying genetic causes by using genome-wide association (GWA) mapping. In the long-term, manipulation of genotype effects, in combination with M. truncatula’s symbiotic relationships with rhizobacteria and arbuscular mycorrhizal fungi, will be important for optimizing legumes for cultivation on long-term space missions.


The Reptile Gut Microbiome: Its Role In Host Evolution And Community Assembly, Timothy John Colston Jan 2017

The Reptile Gut Microbiome: Its Role In Host Evolution And Community Assembly, Timothy John Colston

Electronic Theses and Dissertations

I characterize the endogenous (gut) microbiome of Squamate reptiles, with a particular focus on the suborder Serpentes, and investigate the influence of the microbiome on host evolution and community assembly using samples I collected across three continents in the New and Old World. I developed novel methods for sampling the microbiomes of reptiles and summarized the current literature on non-mammalian gut microbiomes. In addition to establishing a standardized method of collecting and characterizing reptile microbiomes I made novel contributions to the future direction of the burgeoning field of host-associated microbiome research. Through persistent and rigorous fieldwork I amassed the largest …


Towards A Better Understanding Of Secondary Metabolite Production In Toxic Marine Algae, Thuy My Nguyen Jan 2017

Towards A Better Understanding Of Secondary Metabolite Production In Toxic Marine Algae, Thuy My Nguyen

Electronic Theses and Dissertations

Roseofilum reptotaenium is a marine cyanobacteria responsible for the loss of 50% of corals worldwide due to Black Band Disease (BBD). Investigating the basis for secondary metabolite production by R. reptotaenium cultures revealed a suite of potent anti-malarial and anticancer compounds that likely include dolastatin 10 and monomethyl auristatin D (MMAD). These R. reptotaenium cultures are non-axenic (not pure monocultures) and R. reptotaenium appears to require the presence of several heterotrophic bacteria to survive. Scanning Election Microscope (SEM) images show closely associated bacteria. Preliminary metagenomic analysis indicates three dominant non-cyanobacterial phyla: Bacteroidetes, Planctomycetes, and Proteobacteri (?-proteobacteria accounted for >50% of …