Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Gene Expression Regulators Lin-11 And Let-711, In Modulating The Rate Of Aging And Lifespan, In C. Elegans., Tseten Yeshi Jamling
Gene Expression Regulators Lin-11 And Let-711, In Modulating The Rate Of Aging And Lifespan, In C. Elegans., Tseten Yeshi Jamling
University of Kentucky Doctoral Dissertations
lin-11 and let-711 are early-developmental gene expression regulators with no previously known roles in aging regulation. Yet, they show strong aging-correlated expression profiles (Lund, Tedesco et al. 2002). lin-11 is strongly upregulated in very old worm populations, and let-711 is progressively downregulated in aging worm populations. Microarray studies were performed to identify their genome-wide targets, which were then subjected to further lifespan and genetic analysis to investigate their role in C. elegans aging.
The results indicate that the target pools of both lin-11 and let-711 are enriched for aging genes, since a significant number of tested genes increased lifespan. This …