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Phenotypic And Transcriptomic Characterization Of Colonial Phase Variation In The Cholera Pathogen Reveals A Novel Smooth Biofilm-Defective Form, Bliss Nicole Lambert Dec 2018

Phenotypic And Transcriptomic Characterization Of Colonial Phase Variation In The Cholera Pathogen Reveals A Novel Smooth Biofilm-Defective Form, Bliss Nicole Lambert

LSU Doctoral Dissertations

Biofilm formation, through the production of Vibrio polysaccharide (VPS), greatly enhances the environmental fitness and pathogenic success of Vibrio cholerae. As a result of phase variation, V. cholerae can switch from a smooth form to rugose, whose cells produce excess VPS, resulting in highly structured biofilms and greater resistance to stress. To further characterize the reversible process of phase variation, we isolated three colonial lineages. Each lineage began with a smooth parent, N16961, and contained a rugose variant derived from the parent, N16961R, as well as a smooth revertant of the rugose, N16961SD. We found clear phenotypic and transcriptomic …


Speciation And Hybridization In Jamaican-Endemic Streamertail Hummingbirds (Trochilus Polytmus And T. Scitulus), Caroline D. Judy Nov 2018

Speciation And Hybridization In Jamaican-Endemic Streamertail Hummingbirds (Trochilus Polytmus And T. Scitulus), Caroline D. Judy

LSU Doctoral Dissertations

Streamertails hummingbirds (Trochilus polytmus and T. scitulus) are recently diverged sister taxa that appear to have speciated in situ on the island of Jamaica. They are distinguished by male bill color, a secondary sexual trait that is coral red in T. polytmus and jet black in T. scitulus. They hybridize in a narrow zone where their ranges meet in eastern Jamaica. In Chapter 2, I performed a formal population survey of T. scitulus to determine the size of the population, which was unknown. I determined that the total population contains well over 100,000 individuals despite its limited …


Intestinal Microbiome Composition Of An Acute In Vivo Alzheimer’S Disease Rat Model, Jimmy Saravia Nov 2018

Intestinal Microbiome Composition Of An Acute In Vivo Alzheimer’S Disease Rat Model, Jimmy Saravia

Honors Theses

No abstract provided.


Physiological And Genomic Characterization Of Novel Isolate From Om252 Clade Of The Gammaproteobacteria, Emily Nall Nov 2018

Physiological And Genomic Characterization Of Novel Isolate From Om252 Clade Of The Gammaproteobacteria, Emily Nall

Honors Theses

No abstract provided.


A Virtual Screen For Protein Targets: Elucidating Druggability In The Human Proteome With Efindsite, Omar Kana May 2018

A Virtual Screen For Protein Targets: Elucidating Druggability In The Human Proteome With Efindsite, Omar Kana

Honors Theses

No abstract provided.


Characterizing Putative Algal Bicarbonate Transporters In S. Cerevisiae & E. Coli Systems Using Transgenic Vectors, James J. Mickler Apr 2018

Characterizing Putative Algal Bicarbonate Transporters In S. Cerevisiae & E. Coli Systems Using Transgenic Vectors, James J. Mickler

Honors Theses

No abstract provided.


Characterization Of The Interaction Between R. Conorii And Human Host Vitronectin In Rickettsial Pathogenesis, Abigail Inez Fish Apr 2018

Characterization Of The Interaction Between R. Conorii And Human Host Vitronectin In Rickettsial Pathogenesis, Abigail Inez Fish

LSU Doctoral Dissertations

Spotted Fever Group Rickettsia are inoculated into the mammalian host during hematophagous arthropod feeding. Once in the bloodstream and during dissemination, the survival of these pathogens is dependent upon their ability to evade innate host defenses until a proper cellular target is reached. The establishment of a successful infection also relies on the ability of the bacteria to attach and invade target cells, as failure to do so results in destruction of the bacterium. Rickettsia conorii expresses an outer membrane protein, Adr1, which binds the multifunctional human glycoprotein, vitronectin, to promote resistance to complement mediated killing. Homologs of Adr1 are …


Changes In Neural Activation Between Pre-Release And Post-Release Mouth Brooding Astatotilapia Burtoni Females, Victoria Oanh Huynh Apr 2018

Changes In Neural Activation Between Pre-Release And Post-Release Mouth Brooding Astatotilapia Burtoni Females, Victoria Oanh Huynh

Honors Theses

No abstract provided.


Ph Dependence Of Dna Binding By Dna Polymerase I From Pychromonas Ingrahamii And Single Stranded Binding Protein From Deinococcus Radiodurans, Olivia Leonovicz Apr 2018

Ph Dependence Of Dna Binding By Dna Polymerase I From Pychromonas Ingrahamii And Single Stranded Binding Protein From Deinococcus Radiodurans, Olivia Leonovicz

Honors Theses

No abstract provided.


Inhibition Of Carboxyltransferase From Escherichia Coli By Oxadiazolopyrazines, Margaret Mccarron Apr 2018

Inhibition Of Carboxyltransferase From Escherichia Coli By Oxadiazolopyrazines, Margaret Mccarron

Honors Theses

No abstract provided.


Epigenetic Misregulation As A Causal Agent Of Disease: Methylation Analysis And Rna Expression Quantification, Carter Pesson Apr 2018

Epigenetic Misregulation As A Causal Agent Of Disease: Methylation Analysis And Rna Expression Quantification, Carter Pesson

Honors Theses

No abstract provided.


Biochemical Characterization Of Fe-S Cluster Assembly Machinery In Methanogenic Archaea, Nicole Bryer Apr 2018

Biochemical Characterization Of Fe-S Cluster Assembly Machinery In Methanogenic Archaea, Nicole Bryer

Honors Theses

No abstract provided.


Analysis Of Young Alu Elements In The Squirrel Monkey (Saimiri) Lineage For Use As Species-Indicative Molecular Markers, Michael W. Denham Apr 2018

Analysis Of Young Alu Elements In The Squirrel Monkey (Saimiri) Lineage For Use As Species-Indicative Molecular Markers, Michael W. Denham

Honors Theses

No abstract provided.


Artemisia Scoparia Reduces The Effects Of Tnfα-Induced Lipolysis In Murine Adipocytes, Ruth Dunn Apr 2018

Artemisia Scoparia Reduces The Effects Of Tnfα-Induced Lipolysis In Murine Adipocytes, Ruth Dunn

Honors Theses

No abstract provided.


Defining A Species: A Look At The Relationship Of Papio And Theropithecus Using Alu Elements, Paulina Gonzalez-Quiroga Apr 2018

Defining A Species: A Look At The Relationship Of Papio And Theropithecus Using Alu Elements, Paulina Gonzalez-Quiroga

Honors Theses

No abstract provided.


An Investigation Of Maltose Transport System Induction In The Rugose Phase Variant Of Human Pathogen Vibrio Vulnificus, Hira Hasan Apr 2018

An Investigation Of Maltose Transport System Induction In The Rugose Phase Variant Of Human Pathogen Vibrio Vulnificus, Hira Hasan

Honors Theses

No abstract provided.


Analysis Of Protein-Protein Interactions Between The Polybromo Subunit Of A Drosophila Melanogaster Chromatin Remodeling Complex And The Beaf Insulator Protein By Yeast-Two-Hybrid Assay, John Selloriquez Apr 2018

Analysis Of Protein-Protein Interactions Between The Polybromo Subunit Of A Drosophila Melanogaster Chromatin Remodeling Complex And The Beaf Insulator Protein By Yeast-Two-Hybrid Assay, John Selloriquez

Honors Theses

No abstract provided.


3d Modeling And Animation Of The Temporomandibular Joint (Tmj) Of A Human Male With Implications For The Study Of Tmj Dysfunction, Breigh Sonnier Apr 2018

3d Modeling And Animation Of The Temporomandibular Joint (Tmj) Of A Human Male With Implications For The Study Of Tmj Dysfunction, Breigh Sonnier

Honors Theses

No abstract provided.


Infection Kinetics Of Rickettsia Asemboensis And Interaction With Rickettsia Felis Within The Cat Flea (Ctenocephalides Felis), Sabrina Magdalena Camille Valdes Apr 2018

Infection Kinetics Of Rickettsia Asemboensis And Interaction With Rickettsia Felis Within The Cat Flea (Ctenocephalides Felis), Sabrina Magdalena Camille Valdes

Honors Theses

No abstract provided.


Sine Language: Communicating Platy-1 Retrotransposon Propagation In The Aotus Lineage, Jackson Mierl Apr 2018

Sine Language: Communicating Platy-1 Retrotransposon Propagation In The Aotus Lineage, Jackson Mierl

Honors Theses

No abstract provided.


Efficacy Of Compound X (Bedoukian Research, Inc.) On Reducing Fecal Egg Count In Lambs, Mary M. France Apr 2018

Efficacy Of Compound X (Bedoukian Research, Inc.) On Reducing Fecal Egg Count In Lambs, Mary M. France

Honors Theses

No abstract provided.


R1 Retrotransposons In Drosophila Melanogaster Are Transcribed By Rna Polymerase I Upon Heat Shock, Himanshu Shekhar Raje Mar 2018

R1 Retrotransposons In Drosophila Melanogaster Are Transcribed By Rna Polymerase I Upon Heat Shock, Himanshu Shekhar Raje

LSU Doctoral Dissertations

The ribosomal RNA genes of Drosophila melanogaster reside within centromere-proximal nucleolar organizers on both the X and Y chromosomes. Each locus contains between 200-300 tandem repeat rDNA units that encode 18S, 5.8S, and 28S ribosomal RNAs (rRNAs) for ribosome biogenesis. In arthropods like Drosophila, about 60% of rDNA genes are inserted with R1 and/or R2 retrotransposons at specific sites within the 28S regions; these units likely fail to produce functional 28S rRNA. We showed previously that R2 expression increases upon nucleolar stress caused by the loss of a ribosome assembly factor, the Nucleolar Phosphoprotein of 140 kDa (Nopp140). Here …


Evolution Of Alu Elements In The Saimiri And Papio Lineages Of Primates, Jasmine Nicole Brown Baker Mar 2018

Evolution Of Alu Elements In The Saimiri And Papio Lineages Of Primates, Jasmine Nicole Brown Baker

LSU Doctoral Dissertations

Alu elements are approximately 300 base pair (bp) primate specific non- autonomous retrotransposons. Alu elements, a short interspersed element (SINE), account for high copy numbers in all primate genomes. Numerous Alu element subfamilies have undergone varying degrees of activity and amplification within primates. Identification of these subfamilies has proved to be very informative in elucidating phylogenies and as phylogenomic markers. Squirrel monkeys, genus Saimiri, are one of the most well-known neotropical primates and the second most commonly used laboratory monkey. Squirrel monkey species diverged approximately 1.5 million years ago and are native to South America. Despite being well-known, there …


Upregulation Of Coilin Mrna Upon Nopp140-/- In Drosophila Melanogaster., Sara Grace Hubacek Mar 2018

Upregulation Of Coilin Mrna Upon Nopp140-/- In Drosophila Melanogaster., Sara Grace Hubacek

Honors Theses

No abstract provided.


Unintended Consequences For Tanf: An Incubator For Domestic Violence?, Kathryn Rose Deleo Mar 2018

Unintended Consequences For Tanf: An Incubator For Domestic Violence?, Kathryn Rose Deleo

Honors Theses

No abstract provided.