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Articles 1 - 6 of 6
Full-Text Articles in Entire DC Network
The Role Of Bcl-2 Family In Clinical Response Of Chronic Lymphocytic Leukemia, Sayer Rashed Alharbi
The Role Of Bcl-2 Family In Clinical Response Of Chronic Lymphocytic Leukemia, Sayer Rashed Alharbi
ETD Archive
The anti-apoptotic Bcl-2 proteins regulate lymphocyte survival and are over-expressed in lymphoid malignancies, including chronic lymphocytic leukemia (CLL). The small molecule inhibitor ABT-737 binds with high affinity to Bcl-2, Bcl-xl, and Bcl-w but with low affinity to Mcl-1, Bfl-1, and Bcl-b. The active analog of ABT-737, navitoclax, has shown a high therapeutic index in lymphoid malignancies developing a predictive marker for it would be clinically valuable for patient selection or choice of drug combinations. We compared expression of anti-apoptotic Bcl-2 genes that are known to be targeted by ABT-737. Our findings reveal that the relative ratio of Mcl-1 and Bfl-1 …
Study Of The L13a Residues Required For Ribosomal Function, Priyanka Das
Study Of The L13a Residues Required For Ribosomal Function, Priyanka Das
ETD Archive
Ribosome biogenesis, a fundamental process, occurs in the nucleolus. It involves incorporation and association of ribosomal proteins (r-proteins) in the ribosomal subunit. Despite its obligatory and critical role in cellular function, the explicit mechanism of incorporation of different r-proteins into the pre-ribosome is not well understood. Using mammalian cell and r-protein L13a as our model, this study addresses the function and mechanism of r-protein incorporation during ribosome maturation. Published results from our laboratory showed the requirement of the release of L13a from the 60S ribosome to silence a cohort of inflammatory proteins directly at the level of translation thus showing …
Identification Of A Post-Transcriptional Mechanism Regulating Epithelial-Mesenchymal Transition, George S. Hussey
Identification Of A Post-Transcriptional Mechanism Regulating Epithelial-Mesenchymal Transition, George S. Hussey
ETD Archive
No abstract provided.
Biofeedback-Assisted Stress Management Training To Reverse Myocardial Remodeling In Patients With End-Stage Heart Failure, Dana Lynn Schneeberger
Biofeedback-Assisted Stress Management Training To Reverse Myocardial Remodeling In Patients With End-Stage Heart Failure, Dana Lynn Schneeberger
ETD Archive
Heart failure is a progressive disease in which the heart is no longer able to pump sufficient amounts of blood to the body. Over six million Americans currently suffer from heart failure, and although pharmacological and surgical therapies continue to improve, about 50 of people with heart failure still die within five years of diagnosis.As the human heart fails, many structural, cellular and molecular alterations occur that contribute to the decrease in heart function. It has been well-established that some of these alterations are the result of sympathetic nervous system hyperactivation, and decreasing sympathetic input with a beta blocker or …
Structural Basis Of Lman1 Cargo Capture In Er & Release In Ergic, Vaijayanti Das
Structural Basis Of Lman1 Cargo Capture In Er & Release In Ergic, Vaijayanti Das
ETD Archive
No abstract provided.
Mite Dna In Mantle Clips, Robert A. Krebs, Brian D. Allen, Na'tasha M. Evans
Mite Dna In Mantle Clips, Robert A. Krebs, Brian D. Allen, Na'tasha M. Evans
McNair Scholars Works
No abstract provided.