Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Prediction Of Discontinuous B-Cell Epitopes Using Logistic Regression And Structural Information, R. Liu, Jianjun Hu
Prediction Of Discontinuous B-Cell Epitopes Using Logistic Regression And Structural Information, R. Liu, Jianjun Hu
Faculty Publications
Computational prediction of discontinuous B-cell epitopes remains challenging, but it is an important task in vaccine design. In this study, we developed a novel computational method to predict discontinuous epitope residues by combining the logistic regression model with two important structural features, B-factor and relative accessible surface area (RASA). We conducted five-fold cross-validation on a representative dataset composed of antigen structures bound with antibodies and independent testing on Epitome database, respectively. Experimental results indicate that besides the well-known RASA feature, B-factor can also be used to identify discontinuous epitopes. Furthermore, these two features are complementary and their combination can remarkably …