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Highly Accurate Fragment Library For Protein Fold Recognition, Wessam Elhefnawy
Highly Accurate Fragment Library For Protein Fold Recognition, Wessam Elhefnawy
Computer Science Theses & Dissertations
Proteins play a crucial role in living organisms as they perform many vital tasks in every living cell. Knowledge of protein folding has a deep impact on understanding the heterogeneity and molecular functions of proteins. Such information leads to crucial advances in drug design and disease understanding. Fold recognition is a key step in the protein structure discovery process, especially when traditional computational methods fail to yield convincing structural homologies. In this work, we present a new protein fold recognition approach using machine learning and data mining methodologies.
First, we identify a protein structural fragment library (Frag-K) composed of a …