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Properties Of Potential Substrates Of A Cyanobacterial Small Heat Shock Protein, Yichen Zhang Nov 2014

Properties Of Potential Substrates Of A Cyanobacterial Small Heat Shock Protein, Yichen Zhang

Masters Theses

Most proteins must fold into native three-dimensional structures to be functional. But, newly synthesized proteins are at high risk of misfolding and aggregating in the cell. Stress, disease or mutations can also cause protein aggregation. A cyanobacterial small heat shock protein, Hsp16.6, can act as a chaperone to prevent irreversible protein aggregation during heat stress. This thesis is focused on the properties of proteins that were associated with Hsp16.6 during heat stress, and which therefore may be “substrates” of Hsp16.6. Bioinformatics were used to determine if Hsp16.6 preferentially binds to proteins with certain properties, and biochemical studies were performed to …


The Effects Of Construction Activity On The Behavior Of Captive Rhesus Monkeys (Macaca Mulatta), Courtney A. Begnoche Jan 2014

The Effects Of Construction Activity On The Behavior Of Captive Rhesus Monkeys (Macaca Mulatta), Courtney A. Begnoche

Masters Theses 1911 - February 2014

Previous studies have revealed insight into the effects of noises and vibrations on rodents, livestock, and zoo animals, but there is little information about such effects on non-human primates. This study aimed to assess the impact of construction activity on the behavior of animals in a non-human primate (rhesus macaque) facility. Construction activity and modified frequency behavioral data were divided into three phases: baseline (~3 months prior to construction), roof (construction on top of the animal facility), and honors (construction of 7 new buildings adjacent to the facility). We hypothesized that anxiety behaviors (scratch and yawn) would be increased during …