Open Access. Powered by Scholars. Published by Universities.®
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Discretized Geometric Approaches To The Analysis Of Protein Structures, John Holland
Discretized Geometric Approaches To The Analysis Of Protein Structures, John Holland
Dartmouth College Ph.D Dissertations
Proteins play crucial roles in a variety of biological processes. While we know that their amino acid sequence determines their structure, which in turn determines their function, we do not know why particular sequences fold into particular structures. My work focuses on discretized geometric descriptions of protein structure—conceptualizing native structure space as composed of mostly discrete, geometrically defined fragments—to better understand the patterns underlying why particular sequence elements correspond to particular structure elements. This discretized geometric approach is applied to multiple levels of protein structure, from conceptualizing contacts between residues as interactions between discrete structural elements to treating protein structures …
A Multi-Resolution Graph Convolution Network For Contiguous Epitope Prediction, Lisa Oh
A Multi-Resolution Graph Convolution Network For Contiguous Epitope Prediction, Lisa Oh
Dartmouth College Master’s Theses
Computational methods for predicting binding interfaces between antigens and antibodies (epitopes and paratopes) are faster and cheaper than traditional experimental structure determination methods. A sufficiently reliable computational predictor that could scale to large sets of available antibody sequence data could thus inform and expedite many biomedical pursuits, such as better understanding immune responses to vaccination and natural infection and developing better drugs and vaccines. However, current state-of-the-art predictors produce discontiguous predictions, e.g., predicting the epitope in many different spots on an antigen, even though in reality they typically comprise a single localized region. We seek to produce contiguous predicted epitopes, …