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Elucidating Structure, Function, And Small Molecular Interactions Of Human Immunodeficiency Virus And Chikungunya Virus, Kristin Nicole Slater
Elucidating Structure, Function, And Small Molecular Interactions Of Human Immunodeficiency Virus And Chikungunya Virus, Kristin Nicole Slater
Wayne State University Theses
Abstract HIV-1:
Human immunodeficiency virus-1 (HIV-1) is a widespread, incurable retrovirus known to cause
immunodeficiency and a shortened life span. Despite successful treatment methods, HIV-1
frequently mutates, resulting in antiviral resistance. Many therapies target the HIV-1 protease
(PR), which is responsible for cleaving the viral polyprotein essential for its life cycle. HIV-1 PR
often evades treatment by way of mutations and less commonly through residue insertions. We
have identified a clinical isolate with a five residue insertion between residues 28 and 29.
Through molecular dynamics simulations we analyzed the protease protein structure and
determined that the residue insertion created a …
Biochemical, Structural, And Drug Design Studies Of Norovirus And Zika Virus Proteases, Ben Kuiper
Biochemical, Structural, And Drug Design Studies Of Norovirus And Zika Virus Proteases, Ben Kuiper
Wayne State University Dissertations
Noroviruses, which are the leading cause of acute gastroenteritis, cause an estimated 677 million infections and 213,000 deaths each year worldwide. Noroviruses are classified into seven genogroups (GI-GVII); GI, GII, and GIV have been shown to be infectious in humans. However, GII noroviruses cause the majority of outbreaks (89%). No pharmacologic treatment or vaccine currently exists to treat or prevent norovirus infections.
Recently, the development of a norovirus replicon system, a murine model of norovirus infection, and the development of a biochemical protease assay have allowed for the design and development of norovirus inhibitors. However, the replicon and biochemical assay …