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Complex Regulatory Pathways Connect Vfm Quorum-Sensing And Cyclic-Di-Gmp Signaling To Bacterial Virulence In The Phytopathogen Dickeya Dadantii 3937, Biswarup Banerjee
Complex Regulatory Pathways Connect Vfm Quorum-Sensing And Cyclic-Di-Gmp Signaling To Bacterial Virulence In The Phytopathogen Dickeya Dadantii 3937, Biswarup Banerjee
Theses and Dissertations
The bacterial second messenger Bis-(3’-5’)-cyclic dimeric guanosine monophosphate (c-di-GMP) regulates multiple cellular behaviors in most bacteria. Bacterial c-di-GMP signaling involves enzymes that synthesize and degrade c-di-GMP, c-di-GMP binding effectors, and targets that are acted upon by the effectors. So far, the c-di-GMP signaling pathways have been understudied. In this work, we explore the c-di-GMP signaling network further in the phytopathogen Dickeya dadantii 3937. In Chapter 2, we identified VfmE as a c-di-GMP binding transcriptional activator that represses pectate lyase production under a high c-di-GMP condition. VfmE was found to bind c-di-GMP in vitro via the RxxxR motif, similar to PilZ …
The Effects Of An R103q Mutation On The Chemical And Physical Properties Of The Enzyme Cytochrome C Nitrite Reductase (Ccnir), Shahama Alam
The Effects Of An R103q Mutation On The Chemical And Physical Properties Of The Enzyme Cytochrome C Nitrite Reductase (Ccnir), Shahama Alam
Theses and Dissertations
Cytochrome c Nitrite Reductase (ccNiR) is a periplasmic homodimeric decaheme enzyme that catalyzes the reduction of nitrite to ammonium in a process that involves six electrons and eight protons. The project described herein explored the properties of the Shewanella oneidensis R103Q ccNiR variant and compared them to the properties of the wild type enzyme. Under standard assay conditions, which use the strong reducing agent methyl viologen monocation radical (MVred) as an electron source, the R103Q variant still catalyzes reduction of nitrite to ammonium, albeit with an MVred turnover rate that is 20% of the wild type’s (780 ± 50 s-1 …
The Effects Of Hybridization On Skeletal Morphology In Two Closely Related Populations Of Rhesus Macaques (Macaca Mulatta): A Geometric Morphometric Approach, Cody Zachery Schumacher
The Effects Of Hybridization On Skeletal Morphology In Two Closely Related Populations Of Rhesus Macaques (Macaca Mulatta): A Geometric Morphometric Approach, Cody Zachery Schumacher
Theses and Dissertations
Precise identification and classification techniques are vital for the field of paleoanthropology to ensure that hominin fossilized remains are labeled accurately. The morphology of extinct hominin specimens will typically be compared to extant nonhuman primate species because of how closely related they are phylogenetically. Observable similarities in their morphological variation can be examined to infer which traits may be a result of evolution and this can update our understanding of their evolutionary relationships. The genus Macaca displays a level of morphological variation that is similar to that seen in the genus Homo, therefore macaques can be used as an analogous …
Molecular Evolution And Biogeography Of The New World Eptesicus Bats, Xueling Yi
Molecular Evolution And Biogeography Of The New World Eptesicus Bats, Xueling Yi
Theses and Dissertations
Molecular evolution refers to a broad field of studies ranging from microevolution (e.g., population genetics) to macroevolution (e.g., phylogeny), including the bridging field of phylogeography. In natural populations, molecular studies are also combined with biogeography that links biological diversity with geographic distributions to provide a comprehensive understanding of evolutionary processes. The field of molecular evolution has been largely advanced from early exploratory descriptions to statistical tests on biological hypotheses and integrative analyses using sophisticated modeling. However, studies of molecular evolution still face some unresolved questions and challenges, especially in non-model systems. For example, the application of new technology has largely …
Development Of New Treatments For Asthma And Neuropathic Pain Based On Ɣ-Aminobutyric Acid A Receptor (Gabaar) Ligands, Nicolas Mark Zahn
Development Of New Treatments For Asthma And Neuropathic Pain Based On Ɣ-Aminobutyric Acid A Receptor (Gabaar) Ligands, Nicolas Mark Zahn
Theses and Dissertations
The γ-aminobutyric acid A receptor (GABAAR) is a ligand-gated pentameric chloride channel consisting of several identified subunits: α1-6, β1-3, γ1-3, δ, ε, π, θ, ρ1-3.1-2 Typical arrangement of subunits consists of two α subunits, two β subunits, and one γ subunit.3 GABAARs have two binding sites for the endogenous ligand γ-aminobutyric acid (GABA), between the α and β subunits. GABAARs also have a binding site for positive allosteric modulators, such as benzodiazepines, between the α and γ subunits.4-5 Due to their ability to treat anxiety, epilepsy, insomnia, and muscle relaxation, benzodiazepines are widely prescribed pharmaceuticals.6-7 Still, adverse effects result from …