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Trna Aminoacylation: New Protein Players And New Reactions, Whitney Noel Wood
Trna Aminoacylation: New Protein Players And New Reactions, Whitney Noel Wood
Wayne State University Dissertations
TRNA AMINOACYLATION: NEW PROTEIN PLAYERS AND NEW REACTIONS
by
WHITNEY N. WOOD
May 2019
Advisor: Dr. Tamara L. Hendrickson
Major: Chemistry (Biochemistry)
Degree: Doctor of Philosophy
Protein translation must usually occur with high accuracy for an organism to survive. However, Helicobacter pylori, Staphylococcus aureus, and many other microorganisms including important human pathogens, lack one or more aminoacyl-tRNA synthetase (aaRS), the enzymes that typically aminoacylate tRNAs for ribosomal translation. These organisms must use an indirect pathway to aminoacylate some tRNAs. Specifically, H. pylori lacks the genes that encode for asparaginyl- and glutaminyl-tRNA synthetases (AsnRS and GlnRS, respectively). Instead, H. pylori uses …