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Identification And Characterization Of Protein Kinase C Substrates In Human Breast Cells, Xin Zhao
Identification And Characterization Of Protein Kinase C Substrates In Human Breast Cells, Xin Zhao
Dissertations, Theses, and Capstone Projects
Aberrations in PKC signaling can lead to the development of multiple human diseases and the most prominent association of PKC with disease has been in tumor growth and metastasis. PKC and its related pathways have been recognized as promising targets for blocking the malignancy of breast cancer cells. To better understand PKC-mediated pathway in breast cancer cells, it is important to identify the cellular substrates of PKC. The main focus of this work is to identify physiologically relevant cellular substrates of PKC in human breast cells and to characterize their roles in cancer-related phenotypes. The work to be described consists …