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Metabolomic And Genomic Analysis Of Lactobacillus Crispatus Vaginal Isolates, Emiley Watson
Metabolomic And Genomic Analysis Of Lactobacillus Crispatus Vaginal Isolates, Emiley Watson
Electronic Thesis and Dissertation Repository
Lactobacillus crispatus is the dominant species in the vagina of many women. To add to our knowledge of its properties, the metabolic readout of twenty strains was analyzed using liquid chromatography-mass spectrometry (LC-MS). This led to a separation of the strains into two groups, Groups A and B. Notably, five Group B strains produced tyramine, known to raise vaginal pH, and make the environment more favourable to vaginal pathogens. The origin of Group B strains did not correlate with their host having bacterial vaginosis (BV), a condition associated with elevated pH. Five bacteriocins were detected in the genomes. Therefore, differences …
The Group A Streptococci Bacteriocins Facilitate A Competitive Advantage During Nasopharyngeal Infection, Lana Estafanos
The Group A Streptococci Bacteriocins Facilitate A Competitive Advantage During Nasopharyngeal Infection, Lana Estafanos
Electronic Thesis and Dissertation Repository
Pathogenic streptococci have evolved specific systems to eliminate bacterial competitors within their biological niche. In microbial environments, niche competition is often driven by the production of short antimicrobial peptides called bacteriocins; this provides a mechanism by which Streptococcus pyogenes may compete for ecological stability and establish infection. Recent findings from our laboratory have identified two novel Class IIb bacteriocin systems – Streptococcus pyogenes bacteriocin (Spb) JK and MN in the M18 serotype S. pyogenes strain MGAS8232 – that may contribute to nasopharyngeal infection. Here, we show that galactose and CO2 are distinct regulatory cues which induce antimicrobial activity. Under …