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The Effects Of Growth Hormone In Human Melanoma Cell Lines, Ashiya Buckels
The Effects Of Growth Hormone In Human Melanoma Cell Lines, Ashiya Buckels
All ETDs from UAB
Melanoma is less common than basal and squamous cell skin cancers, but is the most aggressive form of skin cancer. ~90% of melanomas carry a mutation in the RAS-RAF pathway, which promotes progression by constitutive activation of the extracellular sig-nal-regulated kinase (ERK) signaling cascade. BRAF inhibition is an effective line of therapy for advance melanoma, but patients often progress due to the development of several forms of treatment resistance. Therapeutic resistance often results in increased invasion and migration of the cancer into proximal and distant tissues leading to the formation of metastasis. Examination of various cancer genomics data sets using …
An Examination Of Secondary Metabolites And Inorganic Acids As Chemical Defenses Against Predation And Fouling In Antarctic And Sub-Tropical Ascidians, Gil Koplovitz
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Palatability of outer tissues of 12 species of ascidians from the Western Antarctic Peninsula was evaluated using the sympatric, omnivorous predator fish Notothenia coriiceps and sea star Odontaster validus. Tissues of 100% of those tested were unpalatable to fish, while 58% were unpalatable to sea stars. Lipophilic and hydrophilic extracts of 11 species were incorporated into pellets and tested in fish and sea star bioassays. Only the lipophilic extract from Distaplia colligans caused sea star and fish feeding deterrence. Organic extracts from 10 ascidian species were also examined in food pellet assays using the sympatric, omnivorous amphipod Gondogeneia antarctica. Only …
Biological, Ecological, And Conservational Implications Of Temperature-Dependent Sex Determination In Sea Turtle Populations, Jennifer Estes Layton
Biological, Ecological, And Conservational Implications Of Temperature-Dependent Sex Determination In Sea Turtle Populations, Jennifer Estes Layton
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Various aspects of TSD were examined in two different sea turtle populations, representing two sea turtle species. Sex ratio was examined in the juvenile portion of the loggerhead sea turtle population in the southeastern U.S. Turtles were captured in the intake channel of the St. Lucie Nuclear Power plant on the central Atlantic coast of Florida. Blood samples were collected from a total of 111 juvenile turtles from May 2005 through April 2007, and the samples were analyzed in a testosterone radioimmunoassay that was validated for use as a sexing technique for sea turtles. The results suggest a significant female-biased …
Living With Stress: Neighborhood Disadvantage, Social Capital, And Depression, John Porter Lillis
Living With Stress: Neighborhood Disadvantage, Social Capital, And Depression, John Porter Lillis
All ETDs from UAB
No abstract provided.