Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Substrate-Based Inhibitors Of Peptidylglycine Á-Amidating Monooxygenase (Pam) As Anti-Proliferative Drugs For Cancer, Geoffrey H. Chew
Substrate-Based Inhibitors Of Peptidylglycine Á-Amidating Monooxygenase (Pam) As Anti-Proliferative Drugs For Cancer, Geoffrey H. Chew
USF Tampa Graduate Theses and Dissertations
C-Terminal glycine-extended prohormones are enzymatically converted to á-amidated peptides, by peptidylglycine á-amidating monooxygenase (PAM). PAM is a bifunctional enzyme with two catalytic domains: peptidylglycine á-hydroxylating monooxygenase (PHM) and peptidylglycine peptidylglycineaminoglycolate lyase (PAL).
PAM has a significant role in the proliferation of androgen-independent prostate cancer. Thus, the inhibition of PAM could halt cancer growth. Hippurate and hippurate analogs were used as lead compounds for developing inhibitors for PAM. The hippurate analogs exhibiting the highest affinity to PAM (lowest inhibition constant) did inhibit the growth of human androgen-independent prostate cancer DU 145 cells.
A Mathematical Model For Colloidal Aggregation, Colleen S. O'Brien
A Mathematical Model For Colloidal Aggregation, Colleen S. O'Brien
USF Tampa Graduate Theses and Dissertations
The characterization of fine particles is an area of immense significance to many industrial endeavors. It has been estimated that 70% of all industrial processes deal with fine particles at some point in the process. A natural phenomenon occurring in these processes is colloidal aggregation. This study examines aggregation in colloidal systems in order to characterize, examine, and control this occurrence in industrial processes. The study of particle aggregation has been broken into many different areas, such as collision mechanisms, interaction energy etc, but a complete model that integrates these different aspects has never been fully realized. A new model …