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Krylov Subspace Spectral Methods With Non-Homogenous Boundary Conditions, Abbie Hendley

Master's Theses

For this thesis, Krylov Subspace Spectral (KSS) methods, developed by Dr. James Lambers, will be used to solve a one-dimensional, heat equation with non-homogenous boundary conditions. While current methods such as Finite Difference are able to carry out these computations efficiently, their accuracy and scalability can be improved. We will solve the heat equation in one-dimension with two cases to observe the behaviors of the errors using KSS methods. The first case will implement KSS methods with trigonometric initial conditions, then another case where the initial conditions are polynomial functions. We will also look at both the time-independent and time-dependent …

Numerical Simulations For Optimal Control Of A Cancer Cell Model With Delay, Jessica S. Lugo

Murray State Theses and Dissertations

Mathematical models are often created to analyze the complicated behavior of many physical systems. One such system is that of the interaction between cancer cells, the immune system, and various treatments such as chemotherapy, radiation, and immunotherapy. Using models that depict these relationships gives researchers insight on the dynamics of this complicated system and possibly ideas for improved treatment schedules.

The model presented here gives the relationship of cancer cells in development phases with immune cells and cycle-specific chemotherapy treatment. This model includes a constant delay term in the mitotic phase. Optimal control theory is used to minimize the cost …