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Insulin Dose Response Curves And Factors Affecting Insulin Sensitivity In Horses, Jeanne D. Lestelle
Insulin Dose Response Curves And Factors Affecting Insulin Sensitivity In Horses, Jeanne D. Lestelle
LSU Master's Theses
Three experiments were conducted to further study the use of intravenous insulin injection to measure insulin sensitivity in horses. In the first experiment, glucose responses to multiple doses of recombinant human insulin were compared in insulin sensitive and insensitive mares. Regression lines describing the responses in insensitive mares had less (P = 0.003) steep slopes and greater (P = 0.006) effective doses at 50% response (ED50) compared to sensitive mares. Curvilinear regression models provided a good fit (R2 = 0.95) for the prediction of ED50 from the individual responses to 50 mU/kg BW insulin. The second experiment estimated the repeatability …
Intravenous Injection Of Insulin For Measuring Insulin Sensitivity In Horses: Effects Of Epinephrine, Feeding Regimen, And Supplementation With Cinnamon For Fish Oil, Lisa Rosalee Earl
Intravenous Injection Of Insulin For Measuring Insulin Sensitivity In Horses: Effects Of Epinephrine, Feeding Regimen, And Supplementation With Cinnamon For Fish Oil, Lisa Rosalee Earl
LSU Master's Theses
Seven experiments were performed to assess the use of glucose responses to insulin injections as a means of estimating insulin sensitivity in horses; to compare the insulin sensitivities of normal horses vs. those displaying hyperleptinemia; and to put this method into practical application. Experiment 3.1 examined dose-responses in mares of potentially different insulin sensitivities. Recombinant human insulin was injected at doses of 8, 20, 50, and 125 mU/kg BW, as needed, to estimate the dose of insulin causing a 50% decrease in glucose concentrations (ED50). Five mares each of low leptin concentrations (LL) and low BCS, LL and high BCS, …