Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 6 of 6
Full-Text Articles in Entire DC Network
Immunohistochemical Localization Of Kisspeptin And Its Receptor In The Equine Ovary, Bryce M. Gilbert
Immunohistochemical Localization Of Kisspeptin And Its Receptor In The Equine Ovary, Bryce M. Gilbert
LSU Master's Theses
Kisspeptin is recognized for its role as the gatekeeper of reproduction in most mammalian species. However, its role in regulation of reproduction at the ovarian level is poorly understood in the horse. In this study, ovaries from follicular phase, luteal phase, anestrous period, and mares treated with ECP-sulpiride were subjected to immunohistochemistry to characterize kisspeptin-10 (Kp10) and its receptor (Kiss1r) protein expression throughout each reproductive stage and follicle type. Kisspeptin and receptor staining was detected in all follicle types (primordial, preantral, and antral) throughout all reproductive stages, as well as oocytes, corpora lutea, and ovulation fossa. The pattern of Kp10 …
Effects Of Adrenergic Or A Combination Of Adrenergic And Opioid Drugs On Assessments Of Insulin Sensitivity In Mares, Lauren Kerrigan
Effects Of Adrenergic Or A Combination Of Adrenergic And Opioid Drugs On Assessments Of Insulin Sensitivity In Mares, Lauren Kerrigan
LSU Master's Theses
Excitement is a problem when conducting endocrine tests on fractious horses. Epinephrine (EPI), for example, was shown to obliterate the insulin-induced decrease in blood glucose concentrations. Sedation may be a solution; however, perturbation of results may preclude useful information. The objectives of the four experiments presented herein were 1) to determine the effects of EPI on insulin response to glucose infusion (IR2G), 2) to assess the effects of the α-adrenergic sedative, detomidine (DET), alone or in combination with the opioid agonist, butorphanol (BUT), on IR2G and glucose response to insulin (GR2I), and 3) to assess the effects of BUT alone …
Factors Affecting Basal And Post-Exercise Prolactin Secretion In Horses, Lisa C. Digiovanni
Factors Affecting Basal And Post-Exercise Prolactin Secretion In Horses, Lisa C. Digiovanni
LSU Master's Theses
There has been thorough documentation to support the role of dopamine in the control of prolactin production and secretion in various mammalian species, including the horse. However, there is evidence that other factors are involved in prolactin secretion. Seven experiments were conducted to assess factors that potentially might affect prolactin secretion in the horse. The first two experiments were conducted (separately) to test whether arginine vasopressin (AVP) or vasoactive intestinal polypeptide (VIP) affected prolactin secretion. In each experiment, AVP or VIP was administered intravenously and blood samples were collected to determine the effect on prolactin secretion. Neither peptide produced any …
Insulin Dose Response Curves And Factors Affecting Insulin Sensitivity In Horses, Jeanne D. Lestelle
Insulin Dose Response Curves And Factors Affecting Insulin Sensitivity In Horses, Jeanne D. Lestelle
LSU Master's Theses
Three experiments were conducted to further study the use of intravenous insulin injection to measure insulin sensitivity in horses. In the first experiment, glucose responses to multiple doses of recombinant human insulin were compared in insulin sensitive and insensitive mares. Regression lines describing the responses in insensitive mares had less (P = 0.003) steep slopes and greater (P = 0.006) effective doses at 50% response (ED50) compared to sensitive mares. Curvilinear regression models provided a good fit (R2 = 0.95) for the prediction of ED50 from the individual responses to 50 mU/kg BW insulin. The second experiment estimated the repeatability …
Repeatability Of Prolactin Responses To Sulpiride In Mares And Geldings And The Effect Of Pergolide And Cabergoline, Rebekah C. Hebert
Repeatability Of Prolactin Responses To Sulpiride In Mares And Geldings And The Effect Of Pergolide And Cabergoline, Rebekah C. Hebert
LSU Master's Theses
Four experiments were conducted in an effort to develop a method, based on prolactin secretion, for assessing the efficacy and duration of activity of dopaminergic agonists for the treatment of pituitary pars intermedia dysfunction (PPID) in horses. In the first experiment, prolactin response to a low dose of the dopamine antagonist, sulpiride, was generally repeatable in estrogen-primed geldings in winter over 8 every-other-day challenges. It was concluded that estrogen-primed, sulpiride-challenged geldings in winter could serve as a model for the study of potential dopaminergic drugs for the treatment of PPID in horses. The second experiment was performed in the summer …
Development And Permeability Of Equine Blastocysts, Brittany Reshel Scott
Development And Permeability Of Equine Blastocysts, Brittany Reshel Scott
LSU Master's Theses
Equine embryo cryopreservation is unsuccessful in larger, more easily collected, day-7 embryos. It is imperative that methods to successfully cryopreserve large equine embryos or develop reliable methods to determine embryo size before collection. Therefore the objectives for this study were to quantify the amount of tritiated glycerol that would permeate various sizes of equine embryos and to determine if circulating progesterone concentration was correlated with in utero embryo size. Mean embryo diameter (± SEM) across treatments (1.4M and 3.4M tritiated glycerol) was 696.5µm ± 108.6µm and 925.9 µm ± 214.1µm, respectively and were not different (P=0.44). The percent permeation for …