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Sequence Analysis Of Pmel17 As Candidate Gene For Causing Rat-Tail Syndrome In Cattle, Benjamin C. Hecht
Sequence Analysis Of Pmel17 As Candidate Gene For Causing Rat-Tail Syndrome In Cattle, Benjamin C. Hecht
Theses and Dissertations
Congenital hypotrichosis in cattle is commonly referred to as "rat-tail" syndrome and is characterized by a dilution of black coat color and morphological changes to the hair shaft and tail switch. Two loci are involved in the inheritance of the rat-tail phenotype, the "extension locus" (MC1R) and an unknown locus. In order to express the rat-tail phenotype the animal must inherit at least one black allele at MC1R and be heterozygous at the unknown locus. The rat-tail locus was previously mapped to an 8.7 cM region of Bos Taurus autosome (BTA) 5. Pmel17 is known to be involved in the …