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In Vitro And In Vivo Identification And Quantification Of Carmofur And 5-Fluorouracil Using Tandem Mass Spectrometry, Mohammad Mohiminul Islam

Theses and Dissertations

Glioblastoma is the most aggressive solid tumor of the brain. Prior studies from our lab found that carmofur, also known as 1-hexylcarbanoyl 5-fluorouracil (HCFU) is a promising candidate in suppressing and killing tumor cell lines compared to the FDA-approved drug temozolomide. Originally developed as pro-drug of 5-fluorouracil (5-FU), carmofur has been in use in clinic for the treatment of colorectal cancer for over four decades in Japan. Having it used in clinics, it has a high probability of repurposing for diseases with no cure such as glioblastoma. Carmofur has also been found effective against other cancers such as head and …

Characterization Of Small Molecules And Ions By Atmospheric Pressure Ionization-Mass Spectrometry, Maleesha De Silva

Theses and Dissertations

Mass spectrometry (MS) has become a widely used technique for the characterization of a wide range of substances in diverse fields. The selection of appropriate ionization techniques, source parameters, charge carriers based on the analyte’s polarity is essential in MS as only the ions are detected. When using a soft ionization technique, single stage-MS at best provides only chemical composition; thus, tandem MS is needed to determine structural information and dissociation pathways. This dissertation focuses on the characterization of various small molecules and ions using different ionization techniques, charge carriers, and collision-induced dissociation (CID).

In Chapter II, commercially available ionic …

Mass Spectrometry Directed Pre-Clinical Studies Of Asthma Candidate Midd0301 And Its Analogs, Md Shadiqur Rashid Roni

Theses and Dissertations

ABSTRACTMASS SPECTROMETRY DIRECTED PRE-CLINICAL STUDIES OF ASTHMA CANDIDATE MIDD0301 AND ITS ANALOGS by Md Shadiqur Rashid Roni The University of Wisconsin-Milwaukee, 2021 Under the Supervision of Professor Alexander (Leggy) Arnold

Asthma is one of the most prevalent global health problems. More than 25 million Americans are suffering from asthma and their symptoms especially in children are not well controlled with current medications. The current therapeutic options to control symptoms are limited and are commonly based on inhaled corticosteroids. There are several reasons for uncontrolled asthma symptoms that includes steroid resistance, improper use of inhalers and very few orally available medications. …

Exploring The Asymmetric Environment Of Various Chiral Catalysts Using A Modified Ion-Trap Mass Spectrometer: Towards The Development Of A Rapid Chiral Catalyst Screening Method, Cary M. Davis

Theses and Dissertations

Since the tragedy of the drug Thalidomide® in the late 1950 to early 1960’s, chirality has been recognized as an important aspect that must be controlled in the drug development process in the pharmaceutical industry. Since then, there has been a considerable movement towards single enantiomer drugs. This demand has presented many challenges for the synthetic organic chemist. Chiral catalysts offer one solution to this problem, as they afford the unique ability to preferentially synthesize one enantiomer. Unfortunately, the design of new chiral catalysts is often empirical, with luck and trial and error necessary due to factors that govern enantioselectivity. …