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Til Death Did Us Part, The Story Of The Health And Death Of Franklin Delano Roosevelt, Mary E. Edgecomb

Graduate Theses

The awe of celebrity, including presidents, creates the impression of beings who are larger than life, without the problems of the common man. Franklin D. Roosevelt, unbeknownst to many Americans, had significant health issues. These health issues predate his paralytic illness and worsened during his presidency. Efforts to maintain his image as the unconquerable president of the United Sates led to concealment of these problems and, in turn, negatively impacted his medical care. While most previous studies focused on individual health issues, this research will show a continuum of medical problems that not only impacted his presidency but also were …

The Relationship Between Death Depression And Death Anxiety Among Cancer Patients In Saudi Arabia, Doaa A. Almostadi

USF Tampa Graduate Theses and Dissertations

Abstract

Cancer is one of the main public health problems in the world. People diagnosed with cancer may become depressed and fearful of dying. This causes them to question treatments and sometimes avoid treatment altogether. Cancer may change the person's life and the lives of others around them. The current study focused on the psychosocial impact of impending death for cancer patients in Saudi Arabia. Currently, the relationship between the death anxiety and death depression in persons with cancer in Saudi Arabia is not yet clear. Added to that, little research has been conducted with Muslim cancer patients and their …

Matrix Metalloproteinase Genes Are Transcriptionally Regulated By E2f Transcription Factors: A Link Between Cell Cycle Control And Metastatic Progression, Jacqueline Lea Johnson

USF Tampa Graduate Theses and Dissertations

The RbµE2F transcriptional regulatory pathway plays a critical role in the cell cycle. Rb is inactivated through multiple waves of phosphorylation, mediated mainly by cyclin D and cyclin E associated kinases. Once Rb is inactivated, cells can enter Sµphase. Collectively, three Rb family members and ten E2F proteins coordinate every additional stage of the cell cycle, from quiescence to mitosis. However the RbµE2F pathway is frequently altered in cancer. Aside from cell proliferation, the RbµE2F pathway regulates other essential cellular processes including apoptosis, cell differentiation, angiogenesis and DNA damage repair pathways, but its role in invasion and cancer progression is …

The Role Of Tumor Suppressors, Ship And Rb, In Immune Suppressive Cells, Michelle Marie Collazo Ruiz

USF Tampa Graduate Theses and Dissertations

Regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSC) have been extensively studied in the past 30-40 years. Their potent suppressive capacity shown in several pathological and clinical settings, such as cancer and transplantation, has made it evident that better understanding their development and function is critical.

Specifically, Tregs play a pivotal role in preventing autoimmunity, graft-versus-host disease (GvHD), and organ graft rejection. We previously demonstrated that germline or induced SH2 domain-containing inositol 5-phosphatase (SHIP) deficiency in the host abrogates GvHD. Here we show that SHIP-deficiency promotes an increase of FoxP3+ cells in both the CD4+CD25+ and the CD4+CD25- T …

Identification Of Novel Stat3 Target Genes Associated With Oncogenesis, Rachel Haviland

USF Tampa Graduate Theses and Dissertations

Cytokine and growth factor signaling pathways involving STAT3 are frequently constitutively activated in many human primary tumors, and are known for the transcriptional role they play in controlling cell growth and cell cycle progression. However, the extent of STAT3's reach on transcriptional control of the genome as a whole remains an important question. We predicted that this persistent STAT3 signaling affects a wide variety of cellular functions, many of which still remain to be characterized.

We took a broad approach to identify novel STAT3 regulated genes by examining changes in the genome-wide gene expression profile by microarray, using cells expressing …

A Study Of Complex Systems: From Magnetic To Biological, Douglas Carroll Lovelady

USF Tampa Graduate Theses and Dissertations

This work is a study of complex many-body systems with non-trivial interactions. Many such systems can be described with models that are much simpler than the real thing but which can still give good insight into the behavior of realistic systems. We take a look at two such systems. The first part looks at a model that elucidates the variety of magnetic phases observed in rare-earth heterostructures at low temperatures: the six-state clock model. We use an ANNNI-like model Hamiltonian that has a three dimensional parameter space and yields two-dimensional multiphase regions in this space. A low-temperature expansion of the …

A Comparative Study Of Knowledge Of Pain Management In Certified And Non-Certified Oncology Nurses, Sherrie A. Lalande

USF Tampa Graduate Theses and Dissertations

Over 1.4 million people are diagnosed with cancer annually. Of those people, 70-90% experience some form of pain. Numerous efforts have been made to educate nurses in the management of pain, yet 30-50% of cancer patients report that their pain is poorly managed. It is not clear whether nurses who obtain certification in Oncology are better equipped to manage this patient population regarding their pain issues. This study compared the knowledge of Oncology Certified Nurses (OCN) and Non-Certified Oncology Nurses (NCON) regarding pain management.

The sample of 41 oncology nurses included 19 who were certified in oncology and 22 who …

Fatigue Symptom Distress And Its Relationship With Quality Of Life In Adult Stem Cell Transplant Survivors, Suzan Fouad Abduljawad R.N., B.S.N.

USF Tampa Graduate Theses and Dissertations

Fatigue is a common problem among cancer patients, especially those who have received chemotherapy and radiation therapy. Stem cell transplant (SCT) patients are at a particular risk of persistent fatigue as they receive more aggressive therapies. This study examined the prevalence of fatigue after completion of SCT. Further, the level of fatigue symptom distress and its relationship with quality of life (QOL) among long term SCT survivors was examined.

The study involved thirty-three patients, 21 males and 12 females, treated with autologous or allogeneic SCT in a comprehensive cancer center in Southwest Florida. Participants' ages ranged from 36 to 70 …

Development And Psychometric Evaluation Of The Chemotherapy Induced Peripheral Neuropathy Assessment Tool, Cindy S. Tofthagen

USF Tampa Graduate Theses and Dissertations

Chemotherapy induced peripheral neuropathy (CIPN) is a common side effect of several chemotherapy drugs used for the treatment of many common malignancies. CIPN is both under-assessed and underreported and few self-report tools exist that measure CIPN. Existing instruments do not evaluate all of the multi-dimensional characteristics of neuropathic symptoms; intensity, distress, timing, and characteristics. The purpose of this descriptive, cross-sectional study was to develop and psychometrically evaluate a new self - report tool for CIPN, the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT). Interviews with 15 patients with known CIPN guided development of the CIPNAT.

The CIPNAT is a 69 …

Evaluation Of The Public Health Risks Associated With Former Manufactured Gas Plants, Robin Brewer Dehate

USF Tampa Graduate Theses and Dissertations

Regulatory agencies have recently focused on assessing the potential for soil vapor intrusion (SVI) and risk posed to occupants of residential and commercial properties overlying and surrounding former Manufactured Gas Plants (MGPs). This study evaluated the potential for SVI at 10 commercial buildings and 26 single family and multi-family residential properties overlying and/or adjacent to three former MGPs. The potential for SVI exposure was categorized into three groupings according to thickness of the vadose zones: no vadose zone; 0 - 6 feet thick, and 6 to 25 feet thick. Indoor and outdoor air and soil vapor samples were collected and …

Regulation Of Bax Activation And Apoptosis By Src And Acetylated Mutant P53, Nicholas Taylor Woods

USF Tampa Graduate Theses and Dissertations

Apoptosis is an inherent suicide mechanism that cells invoke for a variety of reasons including embryo cavitation, tissue homeostasis, excessive DNA damage and aberrant oncogene activation. Apoptosis is regulated by a diverse set of proteins including, but not limited to, the Bcl-2 family. This family set is comprised of both pro-death and pro-survival proteins whose relative expression, localization and/or modifications regulate the balance between life and death for each cell. The keystones to this system are the proapoptotic proteins Bax and Bak, which are regulated by their conformation and localization. However, the exact mechanisms by which Bax and Bak become …

Benzene Related Hematological Disorders: Evidence For A Threshold In Animals And Humans, James Mccluskey

USF Tampa Graduate Theses and Dissertations

Significant benzene exposure has historically been associated with the development of a host of hematological disorders in humans and animals. In particular, benzene is known to cause disturbances of the peripheral blood, aplastic anemia and cancer of the lymphohematopoietic system. In 1928, the first modern report of an association between cancer and benzene exposure was published. This case report was followed by additional reports from around the world. In most instances, ailments resulted from long term, high level exposure to benzene found in glues, and through accidental industrial spills. Throughout the 1960's and 1970's, case reports accumulated linking benzene exposure …

Molecular Mechanism Of Aurora-A Kinase In Human Oncogenesis, Lili He

USF Tampa Graduate Theses and Dissertations

Aurora-A is a mitotic kinase, which regulates cell cycle progression through modulating centrosome function. Aurora-A expression is frequently altered in human malignancies. The discrepancy between overexpression and amplification suggests that elevated Aurora-A level is likely to be regulated also by transcriptional and/or translational modifications. In this study, we have demonstrated: 1) transcriptional regulation of Aurora-A by E2F3; 2) feedback regulation between tumor suppressor CHFR and Aurora-A; 3) CNTD2 as a novel Aurora-A partner and oncogene to activate Aurora-A and induce transformation.

Aurora-A expression and activity are cell cycle regulated. The mechanism of Aurora-A upregulation at onset of mitosis is largely …

Risk Reduction Decision Making In Women With Brca1/2 Gene Mutations, Heidi M. King

USF Tampa Graduate Theses and Dissertations

With technological advances in testing for gene mutations, a new population of BRCA1/2 women is becoming aware of their increased risk for developing breast and/or ovarian cancer. A salient issue these women face is which risk-reducing option to choose. Little is known about the decision making factors underlying the choice of prophylactic mastectomy for women with a BRCA1/2 mutation. To address this issue, 137 unaffected, positive BRCA1/2 gene mutation carriers (42 who opted for prophylactic mastectomy, 95 who did not) served as participants. All women completed an on-line battery that assessed the following theory-based decision making variables: advantages and disadvantages …

Relationship Between Nurses' Management Of Pediatric Oncology Patients' Symptoms And Job Satisfaction, Jennifer I. Rheingans

USF Tampa Graduate Theses and Dissertations

A primary function of the pediatric oncology nurse is to provide symptom management to children with cancer. Symptom management strategies have been published, but there is scarce literature examining neither the actual use of these nursing interventions, nor the effects of using these interventions on the nurses' perceived work environment. The purpose of this study was to examine the nursing interventions used in treating pediatric oncology patients' symptoms, as well as the emotional sequelae from providing this care. Phase One of this study examined the content validity of the newly developed Nurses Distress and Interventions for Symptoms Survey (NDISS) utilizing …

Body Image, Attitudes, And Self-Efficacy As Predictors Of Past Behavior And Future Intention To Perform Breast And Skin Self-Examinations, Sari R. Chait

USF Tampa Graduate Theses and Dissertations

Breast self-examinations (BSE) and skin self-examinations (SSE) provide people with a cost-effective and time-efficient approach to the detection of cancer. Given the utility of these self-examination behaviors, it is important to determine who is likely to perform them regularly and why. Prior research has demonstrated a relationship of attitudes and self-efficacy with performance of and intention to practice the exams. Body image, although not previously studied, can be hypothesized to influence performance of these behaviors as well. To address these issues, the current study sought to determine if there are relationships between attitudes, self-efficacy, and body image and the practice …

Improving Prostate Cancer Detection In Veterans Through The Developement Of A Clinical Decision Rule For Prostate Biopsy, Owen T. Hill

USF Tampa Graduate Theses and Dissertations

In the U.S., the number of prostate biopsies increases annually. This is partly due to elevated prostate specific antigen (PSA) values identified during PC screening. This study's goal was improving prostate cancer (PC) detection through developing a clinical decision rule (CDR), based on an elevated PSA and laboratory biomarkers. This decision rule could be used after an elevated PSA, providing the patient and clinician information to consider prior to biopsy. This cross-sectional study evaluated men from the Tampa, Florida, James A. Haley (JH) VA (N=1,378), from January 1, 1998, through April 15, 2005. The study hypothesized that specific lab biomarkers …

Chronic/Life Threatening Illnesses From The Perspective Of Latino Men, Melissa Sierra

USF Tampa Graduate Theses and Dissertations

Much of the research on illness focuses on how people, particularly white men, cope with chronic/life threatening illnesses often adopting a "sick role" identity. For Latinos this type of identity transformation is complex as there is no place for dependency and passivity in traditional depictions of Latino masculinity. Latino men take pride in their manhood. As a result, they have trouble accepting their illness and the sick role. They do not tend to take their illness seriously, nor are they comfortable admitting to others the seriousness of their illness. My research focuses on how Latino men renegotiate a sense of …

Feminine Beauty And The Cancerous Beast: Appearance Management At The Cancer Hospital Salon, Andrea Wagganer

USF Tampa Graduate Theses and Dissertations

When we choose to alter or manipulate our physical appearance we also manage our presentation of self; we communicate to others about our identity. Salons are typical social spaces for women to engage in body-changing, enhancing or disguising practices and thereby manage their identity. The following ethnographic research explores the intersection of female cancer patients' who request salon services while undergoing appearance altering medical treatments and female cosmetologists who provide such services.

Over a period of 6 months, I volunteered weekly at Hannah's, a hairstyling salon located in a large cancer research and treatment hospital in southern Florida. The following …

The Nuclear Export Of Dna Topoisomerase Iiα In Hematological Myeloma Cell Lines As A Function Of Drug Sensitivity: Clinical Implications And A Theoretical Approach For Overcoming The Observed Drug Resistance, Roxane Engel

USF Tampa Graduate Theses and Dissertations

The focus of this investigation is about DNA topoisomerases, the molecular targets of clinically important chemotherapy, and mechanisms of drug resistance in human myeloma and leukemia cell lines. The ultimate goal of this investigation was to identify mechanism(s) of drug resistance to anticancer agents so that a strategy to overcome drug resistance could be conceived. We established an in vitro cell model by using human leukemia and myeloma cell lines to investigate possible mechanisms of drug resistance that are observed in confluent cells. Plateau cell densities demonstrated de novo drug resistance to commonly used chemotherapeutic agents that was independent of …