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Tests And Refinements Of A General Structure-Activity Model For Avian Repellents, Larry Clark, Pankaj Shah

Larry Clark

We tested the robustness of a structure-activity model for avian trigeminal chemoirritants. Fourteen benzoates and acetophenones were tested using European starlings Sturn us vulgaris as a bioassay. In general. the pre­ viously proposed model was a reasonable predictor of repellency (i.e., irritant potency). We found that the presence of a phenyl ring was critical to repel­ lency. Basicity of the molecule is the next most critical feature influencing repellency. The presence of an acidic function within the electron-withdrawing functionality seriously detracts from repellency. The presence or absence of an electron-withdrawing or -donating group may potentiate repellent effects, but its presence …