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Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller 2010 Old Dominion University

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in ...


Tapping Environmental History To Recreate America’S Colonial Hydrology, Christopher L. Pastore, Mark B. Green, Daniel J. Bain, Andrea Muñoz-Hernandez, Charles J. Vörösmarty, Jennifer Arrigo, Sara Brandt, Jonathan M. Duncan, Francesca Greco, Hyojin Kim, Sanjiv Kumar, Michael Lally, Anthony J. Parolari, Brian Pellerin, Nira Salant, Adam Schlosser, Kate Zalzal 2010 University of New Hampshire, Durham

Tapping Environmental History To Recreate America’S Colonial Hydrology, Christopher L. Pastore, Mark B. Green, Daniel J. Bain, Andrea Muñoz-Hernandez, Charles J. Vörösmarty, Jennifer Arrigo, Sara Brandt, Jonathan M. Duncan, Francesca Greco, Hyojin Kim, Sanjiv Kumar, Michael Lally, Anthony J. Parolari, Brian Pellerin, Nira Salant, Adam Schlosser, Kate Zalzal

Civil and Environmental Engineering Faculty Research and Publications

To properly remediate, improve, or predict how hydrological systems behave, it is vital to establish their histories. However, modern-style records, assembled from instrumental data and remote sensing platforms, hardly exist back more than a few decades. As centuries of data is preferable given multidecadal fluxes of both meteorology/climatology and demographics, building such a history requires resources traditionally considered only useful in the social sciences and humanities. In this Feature, Pastore et al. discuss how they have undertaken the synthesis of historical records and modern techniques to understand the hydrology of the Northeastern U.S. from Colonial times to modern ...


Electro-Osmotic Flow Over A Charged Superhydrophobic Surface, Hui Zhao 2010 University of Nevada, Las Vegas

Electro-Osmotic Flow Over A Charged Superhydrophobic Surface, Hui Zhao

Mechanical Engineering Faculty Publications

Bubbles can be trapped inside textured structures such as grooves, forming a superhydrophobic surface. A superhydrophobic surface has a large effective hydrodynamic slip length compared to a smooth hydrophobic surface and holds the promise of enhancing electrokinetic flows that find many interesting applications in microfluidics. However, recent theoretical studies suggested that electro-osmotic flows over a weakly charged superhydrophobic surface

the zeta potential of the surface is smaller than the thermal potential (25 mV) can only be enhanced when liquid-gas interfaces are charged [T. M. Squires, Phys. Fluids 20, 092105 (2008); Bahga et al., J. Fluid Mech. 644, 245 (2010)]. So ...


Unconventional Uses Of Cantilevers For Chemical Sensing In Gas And Liquid Environments, Isabelle Dufour, Fabien Josse, Stephen M. Heinrich, C. Lucat, C. Ayela, F. Ménil, Oliver Brand 2010 Université de Bordeaux

Unconventional Uses Of Cantilevers For Chemical Sensing In Gas And Liquid Environments, Isabelle Dufour, Fabien Josse, Stephen M. Heinrich, C. Lucat, C. Ayela, F. Ménil, Oliver Brand

Civil and Environmental Engineering Faculty Research and Publications

Microcantilevers used as (bio)chemical sensors are usually coated with a chemically sensitive layer. The coated devices operate either in a static bending regime or in a dynamic flexural mode. While the coated devices operate generally well in both the static and dynamic mode, they do suffer from certain shortcomings depending on the medium of operation and the application, including lack of selectivity and of reversibility of the sensitive coating and a reduced quality factor due to the surrounding medium. In particular, the performance of microcantilevers excited in their standard out-of-plane dynamic mode drastically decreases in viscous liquid media. Moreover ...


Use Of The Soil-Plant-Air-Water Model To Predict Hydraulic Performance Of Vegetative Treatment Areas Controlling Open Lot Runoff, Daniel S. Andersen, Robert T. Burns, Lara B. Moody, Matthew J. Helmers, Robert Horton Jr., Carl H. Pederson 2010 Iowa State University

Use Of The Soil-Plant-Air-Water Model To Predict Hydraulic Performance Of Vegetative Treatment Areas Controlling Open Lot Runoff, Daniel S. Andersen, Robert T. Burns, Lara B. Moody, Matthew J. Helmers, Robert Horton Jr., Carl H. Pederson

Agricultural and Biosystems Engineering Publications

Alternative treatment systems to control runoff from open beef feedlots may enhance environmental security and protect water quality. Several Midwestern states have issued National Pollution Discharge Elimination System permits allowing beef feedlots to use vegetative treatment systems (VTSs) to control and treat feedlot runoff. Monitoring VTSs has provided data to validate performance modeling strategies. The objective of this study was to evaluate the ability of the Soil-Plant-Air-Water (SPAW) model to predict the hydraulic performance of vegetative treatment areas (VTAs). Two approaches, one using the field module and the other the pond module of the SPAW model, were investigated. The model ...


Comparison Of The Iowa State University Effluent Limitation Guidelines Model With The Soil-Plant-Air-Water Model For Evaluating Containment Basin Performance, Daniel S. Andersen, Robert T. Burns, Lara B. Moody, Matthew J. Helmers, Robert Horton Jr. 2010 Iowa State University

Comparison Of The Iowa State University Effluent Limitation Guidelines Model With The Soil-Plant-Air-Water Model For Evaluating Containment Basin Performance, Daniel S. Andersen, Robert T. Burns, Lara B. Moody, Matthew J. Helmers, Robert Horton Jr.

Agricultural and Biosystems Engineering Publications

This article compares results from the Iowa State University Effluent Limitations Guidelines (ISU-ELG) model to results obtained using the Soil-Plant-Air-Water (SPAW) model to simulate feedlot runoff containment basin overflow volume. The objective was to verify that the ISU-ELG model was providing a reasonable prediction of basin overflow. The ISU-ELG model uses a set of guidelines to determine if land application is acceptable, whereas the SPAW model uses a soil moisture criterion. The criterion for determining if a particular day was suitable for land application of basin effluent was investigated to determine the effect on basin overflow volumes. The results show ...


Effect Of Ultrasonic Pretreatment On Methane Production Potential From Corn Ethanol Coproducts, Wei Wu-Haan, Robert T. Burns, Lara B. Moody, Cody John Hearn, David A. Grewell 2010 Iowa State University

Effect Of Ultrasonic Pretreatment On Methane Production Potential From Corn Ethanol Coproducts, Wei Wu-Haan, Robert T. Burns, Lara B. Moody, Cody John Hearn, David A. Grewell

Agricultural and Biosystems Engineering Publications

This article addresses the biochemical methane potential (BMP) production from anaerobic digestion of corn-ethanol coproducts including dried distiller grain with solubles (DDGS), distiller's wet grains (DWG), thin stillage, and condensed distiller's solubles (CDS) as well as evaluating the effects of ultrasonic pretreatment on methane production from these feedstocks. Ultrasonic pretreatment was applied with three amplitude settings of 33% (52.8 µmpp), 66% (105.6 µmpp), and 100% (160 µmpp) as well as five time settings (10, 20, 30, 40, and 50 s) to each of the four coproducts prior to conducting benchtop BMP trials. Ultrasonic pretreatment reduced mean ...


Optimal Coverage Path Planning For Arable Farming On 2d Surfaces, Jian Jin, Lie Tang 2010 Iowa State University

Optimal Coverage Path Planning For Arable Farming On 2d Surfaces, Jian Jin, Lie Tang

Agricultural and Biosystems Engineering Publications

With the rapid adoption of automatic guidance systems in agriculture, automated path planning has great potential to further optimize field operations. Field operations should be done in a manner that minimizes time and travel over field surfaces and should be coordinated with specific field operation requirements, machine characteristics, and topographical features of arable lands. To reach this goal, an intelligent coverage path planning algorithm is the key. To determine the full coverage pattern of a given field by using boustrophedon paths, it is necessary to know whether to and how to decompose a field into sub-regions and how to determine ...


Prediction Of Indoor Climate And Long-Term Air Quality Using The Bta-Aqp Model: Part I. Bta Model Development And Evaluation, Gang Sun, Steven J. Hoff 2010 Iowa State University

Prediction Of Indoor Climate And Long-Term Air Quality Using The Bta-Aqp Model: Part I. Bta Model Development And Evaluation, Gang Sun, Steven J. Hoff

Agricultural and Biosystems Engineering Publications

The objective of this research was to develop a building thermal analysis and air quality predictive (BTA-AQP) model to predict ventilation rate, indoor temperature, and long-term air quality (NH3, H2S, and CO2 concentrations and emissions) for swine deep-pit buildings. This article, part I of II, presents a lumped capacitance model (BTA model) to predict the transient behavior of ventilation rate and indoor air temperature according to the thermo-physical properties of a typical swine building, setpoint temperature scheme, fan staging scheme, transient outside temperature, and the heat fluxes from pigs and supplemental heaters. The obtained ventilation rate and resulting indoor air ...


Soil Loading Effects Of Planter Depth-Gauge Wheels On Early Corn Growth, H. Mark Hanna, Brian L. Steward, Landon Aldinger 2010 Iowa State University

Soil Loading Effects Of Planter Depth-Gauge Wheels On Early Corn Growth, H. Mark Hanna, Brian L. Steward, Landon Aldinger

Agricultural and Biosystems Engineering Publications

Final soil manipulation before seed germination occurs during the planting operation. Contact force of depth-gauge wheels adjacent to the seed opener potentially alters the environment for corn seed germination and early plant growth. A field experiment was conducted measuring seed spacing, spacing variability, seed depth, emergence rate, plant dry matter, final stand, crop growth stage, and extended leaf height with different soil contact loads [light, 180 to 490 N (40 to 110 lb); medium, 490 to 890 N (110 to 200 lb); and heavy, over 890 N (200 lb)] and a range of three soil moistures (dry, moist, wet). A ...


Lab-Scale Assessment Of Gaseous Emissions From Laying-Hen Manure Storage As Affected By Physical And Environmental Factors, Hong Li, Hongwei Xin 2010 Iowa State University

Lab-Scale Assessment Of Gaseous Emissions From Laying-Hen Manure Storage As Affected By Physical And Environmental Factors, Hong Li, Hongwei Xin

Agricultural and Biosystems Engineering Publications

Manure-belt (MB) and high-rise (HR) laying-hen houses are the two predominant housing types in the U.S. Compared with HR houses, MB houses have better indoor air quality and lower aerial emissions as a result of frequent (every 1 to 4 d) manure removal from the hen houses into separate manure storage. However, emissions from on-farm manure storage are integral parts of the whole-farm emissions and need to be quantified. This series of lab-scale studies assesses emission rates (ER) of ammonia (NH3) and greenhouse gases (CH4, CO2, and N2O) from stored laying-hen manure as affected by the following physical and ...


Climate And More Sustainable Cities: Climate Information For Improved Planning And Management Of Cities (Producers/Capabilities Perspective), C.S.B. Grimmond, Matthias Roth, Tim R. Oke, Y. C. Au, M. Best, R. Betts, Gregory R. Carmichael, Helen Cleugh, Walter F. Dabberdt, Rohinton Emmanuel, E. Freitas, K. Fortuniak, Steven Hanna, Petra M. Klein, Laurence S. Kalkstein, C. H. Liu, Alex Nickson, David Pearlmutter, David J. Sailor, James Voogt 2010 King's College London

Climate And More Sustainable Cities: Climate Information For Improved Planning And Management Of Cities (Producers/Capabilities Perspective), C.S.B. Grimmond, Matthias Roth, Tim R. Oke, Y. C. Au, M. Best, R. Betts, Gregory R. Carmichael, Helen Cleugh, Walter F. Dabberdt, Rohinton Emmanuel, E. Freitas, K. Fortuniak, Steven Hanna, Petra M. Klein, Laurence S. Kalkstein, C. H. Liu, Alex Nickson, David Pearlmutter, David J. Sailor, James Voogt

Mechanical and Materials Engineering Faculty Publications and Presentations

In the last two decades substantial advances have been made in the understanding of the scientific basis of urban climates. These are reviewed here with attention to sustainability of cities, applications that use climate information, and scientific understanding in relation to measurements and modelling. Consideration is given from street (micro) scale to neighbourhood (local) to city and region (meso) scale. Those areas where improvements are needed in the next decade to ensure more sustainable cities are identified. High-priority recommendations are made in the following six strategic areas: observations, data, understanding, modelling, tools and education. These include the need for more ...


Evaluation Of Spectral Pretreatments, Partial Least Squares, Least Squares Support Vector Machines And Locally Weighted Regression For Quantitative Spectroscopic Analysis Of Soils, Benoit Igne, James B. Reeves, Gregory McCarty, W. Dean Hively, Eric Lund, Charles R. Hurburgh Jr. 2010 Iowa State University

Evaluation Of Spectral Pretreatments, Partial Least Squares, Least Squares Support Vector Machines And Locally Weighted Regression For Quantitative Spectroscopic Analysis Of Soils, Benoit Igne, James B. Reeves, Gregory Mccarty, W. Dean Hively, Eric Lund, Charles R. Hurburgh Jr.

Agricultural and Biosystems Engineering Publications

Soil testing requires the analysis of large numbers of samples in the laboratory that is often time consuming and expensive. Mid-infrared spectroscopy (mid-IR) and near infrared (NIR) spectroscopy are fast, non-destructive and inexpensive analytical methods that have been used for soil analysis, in the laboratory and in the field, to reduce the need for measurements using complex chemical/physical analyses. A comparison of the use of spectral pretreatment as well as the implementation of linear and non-linear regression methods was performed. This study presents an overview of the use of infrared spectroscopy for the prediction of five physical (sand, silt ...


Electroporation-Mediated Delivery Of A Naked Dna Plasmid Expressing Vegf To The Porcine Heart Enhances Protein Expression, W. G. Marshall Jr., B. A. Boone, J. D. Burgos, S. I. Gografe, M. K. Baldwin, M. L. Danielson, M. J. Larson, D. R. Caretto, Y. Cruz, B. Ferraro, L. C. Heller, K. E. Ugen, M. J. Jaroszeski, R. Heller 2010 Old Dominion University

Electroporation-Mediated Delivery Of A Naked Dna Plasmid Expressing Vegf To The Porcine Heart Enhances Protein Expression, W. G. Marshall Jr., B. A. Boone, J. D. Burgos, S. I. Gografe, M. K. Baldwin, M. L. Danielson, M. J. Larson, D. R. Caretto, Y. Cruz, B. Ferraro, L. C. Heller, K. E. Ugen, M. J. Jaroszeski, R. Heller

Bioelectrics Publications

Gene therapy is an attractive method for the treatment of cardiovascular disease. However, using current strategies, induction of gene expression at therapeutic levels is often inefficient. In this study, we show a novel electroporation (EP) method to enhance the delivery of a plasmid expressing an angiogenic growth factor (vascular endothelial growth factor, VEGF), which is a molecule previously documented to stimulate revascularization in coronary artery disease. DNA expression plasmids were delivered in vivo to the porcine heart with or without coadministered EP to determine the potential effect of electrically mediated delivery. The results showed that plasmid delivery through EP significantly ...


Value Of Condition Monitoring For Optimal Replacement In The Proportional Hazards Model With Continuous Degradation, Xiang Wu, Sarah M. Ryan 2010 Iowa State University

Value Of Condition Monitoring For Optimal Replacement In The Proportional Hazards Model With Continuous Degradation, Xiang Wu, Sarah M. Ryan

Industrial and Manufacturing Systems Engineering Publications

This article investigates the value of perfect monitoring information for optimal replacement of deteriorating systems in the Proportional Hazards Model (PHM). A continuous-time Markov chain describes the condition of the system. Although the form of an optimal replacement policy for system under periodic monitoring in the PHM was developed previously, an approximation of the Markov process as constant within inspection intervals led to a counter intuitive result that less frequent monitoring could yield a replacement policy with lower average cost. This article explicitly accounts for possible state transitions between inspection epochs to remove the approximation and eliminate the cost anomaly ...


The Effects Of Horizontal Load Speed And Lifting Frequency On Lifting Technique And Biomechanics, Boyi Dai, Sangeun Jin, Xiaopeng Ning, Gary Mirka 2010 Iowa State University

The Effects Of Horizontal Load Speed And Lifting Frequency On Lifting Technique And Biomechanics, Boyi Dai, Sangeun Jin, Xiaopeng Ning, Gary Mirka

Industrial and Manufacturing Systems Engineering Publications

Lifting loads that have a horizontal velocity (e.g. lifting from a conveyor) is often seen in industry and it was hypothesised that the inertial characteristics of these loads may influence lifting technique and low back stress. Seventeen male participants were asked to perform lifting tasks under conditions of four horizontal load speeds (0 m/s, 0.7 m/s, 1.3 m/s and 2.4 m/s) and two lifting frequencies (10 and 20 lifts/min) while trunk motions and trunk muscle activation levels were monitored. Results revealed that increasing horizontal load speed from 0 m/s to ...


Swine Producer Appraisal Of The Community Assessment Model For Odor Dispersion (Cam), John C. Tyndall, Jay D. Harmon, Steven J. Hoff 2010 Iowa State University

Swine Producer Appraisal Of The Community Assessment Model For Odor Dispersion (Cam), John C. Tyndall, Jay D. Harmon, Steven J. Hoff

Agricultural and Biosystems Engineering Publications

The community assessment model (CAM) for odor dispersion is a tool to assist in the siting of swine production facilities. CAM considers the size and type of a swine production system, local historical weather conditions, and odor control implementation. It predicts the number of hours of exposure to various levels of odor, by month, for each receptor in a given community. A follow-up survey of all CAM users since 2005 was conducted. The survey was designed to provide: 1) formative feedback for programming adjustments to improve Extension efficiency, usability, and reduce costs; and 2) summative feedback used to provide an ...


Communicating The Sum Of Sources In A 3- Sources/3-Terminals Network; Revisited, Michael Landberg, Aditya Ramamoorthy 2010 Open University of Israel

Communicating The Sum Of Sources In A 3- Sources/3-Terminals Network; Revisited, Michael Landberg, Aditya Ramamoorthy

Electrical and Computer Engineering Conference Papers, Posters and Presentations

We consider the problem of multicasting sums over directed acyclic networks with unit capacity edges. A set of source nodes si observe independent unit-entropy source processes Xi and want to communicate Σ Xi to a set of terminals tj. Previous work on this problem has established necessary and sufficient conditions on the si -tj connectivity in the case when there are two sources or two terminals (Ramamoorthy '08), and in the case of three sources and three terminals (Langberg-Ramamoorthy '09). In particular the latter result establishes that each terminal can recover the sum if there are two edge disjoint paths ...


Integral Equation Analysis Of Electromagnetic Wave Propagation In Periodic Structure And Error Analysis Of Various Basis Functions In Projection Of Plane Waves, Fu-gang Hu 2010 Iowa State University

Integral Equation Analysis Of Electromagnetic Wave Propagation In Periodic Structure And Error Analysis Of Various Basis Functions In Projection Of Plane Waves, Fu-Gang Hu

Graduate Theses and Dissertations

In the first part of this dissertation, the integral equation approaches are developed to analyze the wave propagation in periodic structures. Firstly, an integral equation approach is developed to analyze the two-dimensional (2-D) scattering from multilayered periodic array. The proposed approach is capable of handling scattering from the array filled with different media in different layers.

Combining the equivalence principle algorithm and connection scheme (EPACS), it can be avoided to find and evaluate the multilayered periodic Green's functions. For 2^N identical layers, the elimination of the unknowns between top and bottom surfaces can be accelerated using the logarithm ...


Creating A Responsive, Real-Time, Malleable Environment For Dancers, Valerie Jane Williams 2010 Iowa State University

Creating A Responsive, Real-Time, Malleable Environment For Dancers, Valerie Jane Williams

Graduate Theses and Dissertations

The traditional choreographer/dancer paradigm uses the dancer as a tool of the choreographer. By contrast, a real-time responsive environment, consisting of rendered video and motion-generated video and sound allows the dancer to become a co-creator in both the rehearsal process and the performances. A malleable visual and sonic environment means that the dancer's relation to their environment becomes a self-directed mixture of expressive and responsive elements. This results in a more authentic experience, as the dancer can use his or her movement to not just alter the environment, but use that environment to accompany the dancer rather than ...


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