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Conference Program, Jon Molina-Aldareguia 2019 IMDEA Materials Institute, Spain

Conference Program, Jon Molina-Aldareguia

Nanomechanical Testing in Materials Research and Development VII

No abstract provided.


System And Method For Sensing Wind Flow Passing Over Complex Terrain, Saleh Nabi, Piyush Grover, Mithu Debnath 2019 University of Nebraska - Lincoln

System And Method For Sensing Wind Flow Passing Over Complex Terrain, Saleh Nabi, Piyush Grover, Mithu Debnath

Mechanical & Materials Engineering Faculty Publications

A wind flow sensing system determines a first approximation of the velocity field at each of the altitudes by simulating computational fluid dynamics ( CFD ) of the wind flow with operating parameters reducing a cost function of a weighted combination of errors , determines a horizontal derivative of vertical velocity at each of the altitudes from the first approximation of the velocity fields , and determines a second approximation of the velocity fields using geometric relationships between a velocity field for each of the altitudes , projections of the measurements of radial velocities on the three - dimensional axes , and the horizontal derivative of vertical ...


Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali 2019 The University of Texas at Tyler

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Mohammed Ali

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva Handihaler, Advair Diskus, and Pulmicort Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available DPIs by means of ...


Multi-Agent Control System And Method, Piyush Grover, Karthik Elamvazhuthi 2019 University of Nebraska - Lincoln

Multi-Agent Control System And Method, Piyush Grover, Karthik Elamvazhuthi

Mechanical & Materials Engineering Faculty Publications

Motion of multiple agents with identical non - linear dynamics is controlled to change density of the agents from the initial to the final density . A first control problem is formulated for optimizing a control cost of changing density of the agents from the initial density to the final density subject to dynamics of the agents in a density space . The first control problem , which is a non - linear non - convex problem over a multi - agent control and a density of the agents , is trans formed into a second control problem over the density of the agents and a product of ...


Peptide Nanotube Encapsulated Enzyme Biosensor For Vapor Phase Detection Of Malathion, An Organophosphorus Compound, Christopher W. Edwards, Surachet Duanghathaipornsuk, Mark N. Goltz, Sushil Kanel, Dong-Shik Kim 2019 University of Toledo

Peptide Nanotube Encapsulated Enzyme Biosensor For Vapor Phase Detection Of Malathion, An Organophosphorus Compound, Christopher W. Edwards, Surachet Duanghathaipornsuk, Mark N. Goltz, Sushil Kanel, Dong-Shik Kim

Faculty Publications

This study explores the use of a butyrylcholinesterase (BChE)-based, reversible reaction biosensor using screen-printed electrodes (SPEs) having a smaller working surface area than the single-use electrodes previously studied. Previous research demonstrated the prospective application of a single-use biosensor fabricated with an acetylcholinesterase (AChE) enzyme encapsulated in peptide nanotubes (PNTs) and enhanced with horseradish peroxidase (HRP) to detect organophosphorus compounds (OPCs) in aqueous and gas phases. In the current study, potential improvements to the biosensor are investigated. BChE-based biosensors were fabricated using PNTs, HRP, and Nafion in combination to increase the reactive surface area, enhance sensitivity, and maintain enzyme stability ...


3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan 2019 Xi'an Polytechnic University & University of Nebraska Medical Center & Donghua University

3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan

Mechanical & Materials Engineering Faculty Publications

3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering. In this study, we developed a composite bioink consisting of silk fibroin (SF), gelatin (GEL), hyaluronic acid (HA), and tricalcium phosphate (TCP) and 3D bioprinted the silk fibroin-based hybrid scaffolds. The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma (PRP) to generate PRP coated scaffolds. Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells (HADMSC). In addition, the treatment ...


3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan 2019 Xi'an Polytechnic University & University of Nebraska Medical Center & Donghua University

3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan

Mechanical & Materials Engineering Faculty Publications

3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering. In this study, we developed a composite bioink consisting of silk fibroin (SF), gelatin (GEL), hyaluronic acid (HA), and tricalcium phosphate (TCP) and 3D bioprinted the silk fibroin-based hybrid scaffolds. The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma (PRP) to generate PRP coated scaffolds. Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells (HADMSC). In addition, the treatment ...


Minimalistic Peptide-Based Supramolecular Systems Relevant To The Chemical Origin Of Life, Daniela Kroiss 2019 The Graduate Center, City University of New York

Minimalistic Peptide-Based Supramolecular Systems Relevant To The Chemical Origin Of Life, Daniela Kroiss

All Dissertations, Theses, and Capstone Projects

All forms of life are based on biopolymers, which are made up of a selection of simple building blocks, such as amino acids, nucleotides, fatty acids and sugars. Their individual properties govern their interactions, giving rise to complex supramolecular structures with highly specialized functionality, including ligand recognition, catalysis and compartmentalization. In this thesis, we aim to answer the question whether short peptides could have acted as precursors of modern proteins during prebiotic evolution. Using a combination of experimental and computational techniques, we screened a large molecular search space for peptide sequences that are capable of forming supramolecular complexes with adenosine ...


Roles Of Surfactant And Binary Polymers On Dissolution Enhancement Of Bcs Ii Drugs From Nanocomposites And Amorphous Solid Dispersions, Md Mahbubur Rahman 2019 New Jersey Institute of Technology

Roles Of Surfactant And Binary Polymers On Dissolution Enhancement Of Bcs Ii Drugs From Nanocomposites And Amorphous Solid Dispersions, Md Mahbubur Rahman

Dissertations

Drug nanocomposites and amorphous solid dispersions (ASDs) are two major formulation platforms used for the bioavailability enhancement of BCS Class II drugs. The major drawback of nanocomposites is their inability to attain high drug supersaturation during in vitro (<50% relative supersaturation) and in vivo dissolution. On the other hand, formulating an amorphous solid dispersion (ASD) with high drug loading (>20%) that releases drug rapidly, while generating and maintaining high supersaturation over at least three hours is challenging. The goal of this thesis is to develop a fundamental understanding of the impact of anionic surfactants–polymers on in vitro drug release from nanocomposites and ASDs, while addressing the above challenges. To achieve this goal, the following objectives are set: (1) compare griseofulvin ...


Nanogaps On Atomically Thin Materials As Non-Volatile Read/Writable Memory Devices, Douglas Robert Strachan, Abhishek Sundararajan, Mathias Joseph Boland 2019 University of Kentucky

Nanogaps On Atomically Thin Materials As Non-Volatile Read/Writable Memory Devices, Douglas Robert Strachan, Abhishek Sundararajan, Mathias Joseph Boland

Physics and Astronomy Faculty Patents

The present invention relates to the presence of nanogaps across a metal dispersed over an atomically-thin material, such that the nanogap exposes the atomically-thin material. The resulting device offers an ultra-short gap with ballistic transport and demonstrated switching in the presence of a gate or dielectric material in close proximity to the channel.


Interface Effects On He Ion Irradiation In Nanostructured Materials, Wenfan Yang, Jingyu Pang, Shijian Zheng, Jian Wang, Xinghang Zhang, Xiuliang Ma 2019 Chinese Academy of Sciences & University of Science and Technology of China

Interface Effects On He Ion Irradiation In Nanostructured Materials, Wenfan Yang, Jingyu Pang, Shijian Zheng, Jian Wang, Xinghang Zhang, Xiuliang Ma

Mechanical & Materials Engineering Faculty Publications

In advanced fission and fusion reactors, structural materials suffer from high dose irradiation by energetic particles and are subject to severe microstructure damage. He atoms, as a byproduct of the (n) transmutation reaction, could accumulate to form deleterious cavities, which accelerate radiation-induced embrittlement, swelling and surface deterioration, ultimately degrade the service lifetime of reactor materials. Extensive studies have been performed to explore the strategies that can mitigate He ion irradiation damage. Recently, nanostructured materials have received broad attention because they contain abundant interfaces that are efficient sinks for radiation-induced defects. In this review, we summarize and analyze the current understandings ...


Synthesis And Optical Properties Of Ordered-Vacancy Perovskite Cesium Bismuth Halide Nanocrystals, Rainie D. Nelson, Kalyan Santra, Y. Wang, Atefe Hadi, Jacob W. Petrich, Matthew G. Panthani 2019 Iowa State University

Synthesis And Optical Properties Of Ordered-Vacancy Perovskite Cesium Bismuth Halide Nanocrystals, Rainie D. Nelson, Kalyan Santra, Y. Wang, Atefe Hadi, Jacob W. Petrich, Matthew G. Panthani

Matthew Panthani

Perovskite-phase cesium bismuth halide (Cs3Bi2X9; X = Cl, Br, I) nanocrystals were synthesized using a hot-injection approach. These nanocrystals adopted ordered-vacancy perovskite crystal structures and demonstrated composition-tunable optical properties. Growth occurred by initial formation of Bi0 seeds, and morphology was controlled by precursor and seed concentration. The Cs3Bi2I9 nanocrystals demonstrated excellent stability under ambient conditions for several months. Contrary to previous reports, we find that photoluminescence originates from the precursor material as opposed to the Cs3Bi2X9 nanocrystals.


The Linc Complex, Mechanotransduction, And Mesenchymal Stem Cell Function And Fate, Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosebohm, Ruiguo Yang, Bin Duan, Jung Yul Lim 2019 University of Nebraska-Lincoln

The Linc Complex, Mechanotransduction, And Mesenchymal Stem Cell Function And Fate, Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosebohm, Ruiguo Yang, Bin Duan, Jung Yul Lim

Mechanical & Materials Engineering Faculty Publications

Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear envelope proteins as a key player in sensing and relaying mechanical signals in MSCs to modulate cellular form, function, and differentiation. Of particular interest is the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex that includes nesprin and SUN. In this review, the way in which cells can sense external mechanical environments through an intact nuclear envelope and LINC complex proteins will be briefly described. Then ...


Organically Modified Inorganic Nanoparticles For Halochromic Ionophores And Nucleic Acids, William Johnston 2019 Louisiana Tech University

Organically Modified Inorganic Nanoparticles For Halochromic Ionophores And Nucleic Acids, William Johnston

Doctoral Dissertations

In this dissertation, four nanoparticle reaction schemes were developed as substrates for halochromic dyes or nucleic acids. The reaction schemes include the use of two substrates: silica nanoparticles and halloysite nanotubes. The protocols can incorporate silica (SiO2) nanoparticles and halloysite aluminosilicate (AlO2SiO2) nanotubes due to the presence of silane groups on the surface of either substrate. The reaction schemes are presented along with detailed protocols which were written to facilitate both reproducibility and to serve as an aid to further study and for easy modification of the protocol to suit a researcher's needs. The data is discussed in the ...


Increasing The Functionality Of Additive Manufacturing Through Atmospheric Microplasma And Nanotechnology, Alexander Jon Ulrich 2019 Louisiana Tech University

Increasing The Functionality Of Additive Manufacturing Through Atmospheric Microplasma And Nanotechnology, Alexander Jon Ulrich

Doctoral Dissertations

Additive Manufacturing (AM) has been changing the manufacturing landscape for the last 20 years. As the interest and demand for both polymer and metal-based 3D printing has grown, the materials and machines used have increased in capabilities. Despite the growth and advancement, there are still a large number of improvements that can be made to add functionality to 3D printers. Metal AM, a subcategory of 3D printing, has garnered much attention among industrial applications with large companies such as General Electric trying to implement the technology to increase innovative designs for motors. Some of the limitations on AM have to ...


Stamped Multilayer Graphene Laminates For Disposable In-Field Electrodes: Application To Electrochemical Sensing Of Hydrogen Peroxide And Glucose, Loreen R. Stromberg, John A. Hondred, Delaney Sanborn, Deyny Mendivelso-Perez, Srikanthan Ramesh, Iris V. Rivero, Josh Kogot, Emily Smith, Carmen Gomes, Jonathan C. Claussen 2019 Iowa State University

Stamped Multilayer Graphene Laminates For Disposable In-Field Electrodes: Application To Electrochemical Sensing Of Hydrogen Peroxide And Glucose, Loreen R. Stromberg, John A. Hondred, Delaney Sanborn, Deyny Mendivelso-Perez, Srikanthan Ramesh, Iris V. Rivero, Josh Kogot, Emily Smith, Carmen Gomes, Jonathan C. Claussen

Mechanical Engineering Publications

A multi-step approach is described for the fabrication of multi-layer graphene-based electrodes without the need for ink binders or post-print annealing. Graphite and nanoplatelet graphene were chemically exfoliated using a modified Hummers’ method and the dried material was thermally expanded. Expanded materials were used in a 3D printed mold and stamp to create laminate electrodes on various substrates. The laminates were examined for potential sensing applications using model systems of peroxide (H2O2) and enzymatic glucose detection. Within the context of these two assay systems, platinum nanoparticle electrodeposition and oxygen plasma treatment were examined as methods for improving sensitivity. Electrodes made ...


On The Measurement Of Energy Dissipation Of Adhered Cells With The Quartz Microbalance With Dissipation Monitoring, Amir Monemian Esfahani, Weiwei Zhao, Jennifer Y. Chen, Changjin Huang, Ning Xi, Jun Xi, Ruiguo Yang 2019 University of Nebraska-Lincoln

On The Measurement Of Energy Dissipation Of Adhered Cells With The Quartz Microbalance With Dissipation Monitoring, Amir Monemian Esfahani, Weiwei Zhao, Jennifer Y. Chen, Changjin Huang, Ning Xi, Jun Xi, Ruiguo Yang

Mechanical & Materials Engineering Faculty Publications

We previously reported the finding of a linear correlation between the change of energy dissipation (ΔD) of adhered cells measured with the quartz crystal microbalance with dissipation monitoring (QCM-D) and the level of focal adhesions of the cells. To account for this correlation, we have developed a theoretical framework for assessing the ΔD-response of adhered cells. We rationalized that the mechanical energy of an oscillating QCM-D sensor coupled with a cell monolayer is dissipated through three main processes: the interfacial friction through the dynamic restructuring (formation and rupture) of cell-extracellular matrix (ECM) bonds, the interfacial viscous damping by the liquid ...


Evaluating The Rheological And Tribological Behaviors Of Coconut Oil Modified With Nanoparticles As Lubricant Additives, Vicente Cortes, Javier A. Ortega 2019 The University of Texas Rio Grande Valley

Evaluating The Rheological And Tribological Behaviors Of Coconut Oil Modified With Nanoparticles As Lubricant Additives, Vicente Cortes, Javier A. Ortega

Mechanical Engineering Faculty Publications and Presentations

In metal-forming processes, the use of lubricants for providing desirable tribological conditions at the tool–workpiece interface is critical to increase the material formability and prolonging tool life. Nowadays, the depletion of crude oil reserves in the world and the global concern in protecting the environment from contamination have renewed interest in developing environmentally-friendly lubricants derived from alternative sources such as vegetable oils. In the present study, the rheological and tribological behavior of coconut oil modified with nanoparticle additives was experimentally evaluated. Two different nanoparticle additives were investigated: Silicon dioxide (SiO2) and copper oxide (CuO). For the two conditions ...


Thermal Interface Material, Matthew Collins Weisenberger, John Davis Craddock 2019 University of Kentucky

Thermal Interface Material, Matthew Collins Weisenberger, John Davis Craddock

Center for Applied Energy Research Faculty Patents

A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes in a free standing film form not adhered to the synthesis substrate, with a matrix infiltrated interstitially into the nanotube array with access to the nanotube tips from both the top and bottom. That is, the infiltrant is purposely limited from over-filling or coating one or both exterior top and/or bottom surfaces of the array, blocking access to the tips. A typical matrix is a polymer material.


Fabrication Of High-Resolution Graphene-Based Flexible Electronics Via Polymer Casting, Metin Uz, Kyle Jackson, Maxsam S. Donta, Juhyung Jung, Matthew T. Lentner, John A. Hondred, Jonathan C. Claussen, Surya K. Mallapragada 2019 Iowa State University

Fabrication Of High-Resolution Graphene-Based Flexible Electronics Via Polymer Casting, Metin Uz, Kyle Jackson, Maxsam S. Donta, Juhyung Jung, Matthew T. Lentner, John A. Hondred, Jonathan C. Claussen, Surya K. Mallapragada

Chemical and Biological Engineering Publications

In this study, a novel method based on the transfer of graphene patterns from a rigid or flexible substrate onto a polymeric film surface via solvent casting was developed. The method involves the creation of predetermined graphene patterns on the substrate, casting a polymer solution, and directly transferring the graphene patterns from the substrate to the surface of the target polymer film via a peeling-off method. The feature sizes of the graphene patterns on the final film can vary from a few micrometers (as low as 5 µm) to few millimeters range. This process, applied at room temperature, eliminates the ...


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