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Electrical Stimulus Controlled Binding/Unbinding Of Human Thrombin-Aptamer Complex, Pranav Shrotriya, Agnivo Gosai, Xiao Ma, Ganesh Balasubraminian 2018 Iowa State University

Electrical Stimulus Controlled Binding/Unbinding Of Human Thrombin-Aptamer Complex, Pranav Shrotriya, Agnivo Gosai, Xiao Ma, Ganesh Balasubraminian

Pranav Shrotriya

The binding/unbinding of the human thrombin and its 15-mer single stranded DNA aptamer, under the application of external stimulus in the form of electrostatic potential/electric field, is investigated by a combination of continuum analysis and atomistic molecular dynamics simulation. In agreement with the experiments that demonstrate the influence of electrostatic potential on the thrombin/aptamer complex, our computations show that the application of positive electric field successfully unbinds the thrombin from the aptamer. Results from umbrella sampling simulations reveal that there is a decrease in the free energy of binding between the thrombin and aptamer in presence of ...


Characterizing Granular Mixing Homogeneity At Various Dimensionless Mixing Lengths In A Double Screw Mixer, Todd A. Kingston, Theodore J. Heindel 2017 Iowa State University

Characterizing Granular Mixing Homogeneity At Various Dimensionless Mixing Lengths In A Double Screw Mixer, Todd A. Kingston, Theodore J. Heindel

Theodore J. Heindel

Granular mixing processes are commonly used to increase product homogeneity in many industrial applications involving pharmaceuticals, food processing, and energy conversion. Determining the appropriate granular mixing length is necessary to avoid over/under mixing and unnecessary power consumption. The goal of this study is to experimentally characterize the granular mixing process and determine, under various operating conditions, the needed mixing length to achieve adequate mixing in a laboratory-scale double screw mixer. Nine different combinations of screw rotation speeds and dimensionless screw pitches are used to investigate the rate of mixing at dimensionless mixing lengths of L/D = 2, 5, and ...


Visualization And Composition Analysis To Quantify Mixing In A Screw Pyrolyzer, Todd A. Kingston, Theodore J. Heindel 2017 Iowa State University

Visualization And Composition Analysis To Quantify Mixing In A Screw Pyrolyzer, Todd A. Kingston, Theodore J. Heindel

Theodore J. Heindel

Characterizing the mixing effectiveness of systems or processes in granular applications is difficult due to ineffective sampling procedures and a lack of quantifiable measurement techniques. The mixing effectiveness of a screw pyrolyzer consisting of a binary mixture of 500–6350 μm red oak chips and 300–500 μm glass beads is evaluated using optical visualization and composition analysis techniques. The mass fraction of binary mixture samples is determined and the weighted sample variance from four outlet ports is used to evaluate the mixing effectiveness. The effect of dimensionless screw pitch on the mixing effectiveness is investigated at levels of p ...


Comparison Of A Virtual Game-Day Experience On Varying Devices, Jack Miller, Holly Baiotto, Anastacia MacAllister, Melynda Hoover, Gabriel Evans, Jonathan Schlueter, Vijay Kalivarapu, Eliot H. Winer 2017 Iowa State University

Comparison Of A Virtual Game-Day Experience On Varying Devices, Jack Miller, Holly Baiotto, Anastacia Macallister, Melynda Hoover, Gabriel Evans, Jonathan Schlueter, Vijay Kalivarapu, Eliot H. Winer

Anastacia MacAllister

Collegiate athletics, particularly football, provide tremendous value to schools through branding, revenue, and publicity. As a result, extensive effort is put into recruiting talented students. When recruiting, home games are exceptional tools used to show a school's unique game-day atmosphere. However, this is not a viable option during the offseason or for off-site visits. This paper explores a solution to these challenges by using virtual reality (VR) to recreate the game-day experience. The Virtual Reality Application Center in conjunction with Iowa State University (ISU) athletics, created a VR application mimicking the game-day experience at ISU. This application was displayed ...


Modeling Acoustic Microfluidic Phenomena In Unconventional Geometries, Andrew Ledbetter 2017 Washington University in St Louis

Modeling Acoustic Microfluidic Phenomena In Unconventional Geometries, Andrew Ledbetter

Engineering and Applied Science Theses & Dissertations

In this work, the performance of a piezoelectrically-actuated ultrasonic droplet generator is analyzed by modeling the harmonic response of a two-dimensional representation of the device cross-section. Observed vibrational and acoustic resonances provide insight into optimal design conditions to achieve efficient, robust droplet ejection. Numerical simulations highlight the importance of the coupled electrical and mechanical behavior of the resonator assembly and show that elastic modes can effectively amplify or dampen acoustic modes within the fluid chamber. Experimentally-validated modeling results guide development of an optimization strategy to further improve device performance. In addition, the standing acoustic field that is the focus of ...


Museum Wave Tank Design, David James Streng, Lisa Michelle Dischinger, John Frederick Niemoller 2017 Cal Poly Slo

Museum Wave Tank Design, David James Streng, Lisa Michelle Dischinger, John Frederick Niemoller

Mechanical Engineering

The Santa Maria Discovery Museum would like to add a tsunami wave tank to be one of their demonstrations. The wave tank needs to draw the attention of their young crowd and be educationally informative about the shapes and effects of waves. As this is a museum demonstration for children, the structure, user interface, and wave making mechanism must be durable.

We are a senior project team from California Polytechnic State University that worked on this project with Allan Hancock College and Stanford University. We created waves by rapidly moving a plunger vertically in the water column. This project allows ...


Dyno-Mite Redesign, Brandon Joseph Miller, Daniel Robert Hoffman, Richard DeMedici Young 2017 California Polytechnic State University, San Luis Obispo

Dyno-Mite Redesign, Brandon Joseph Miller, Daniel Robert Hoffman, Richard Demedici Young

Mechanical Engineering

The Cal Poly Mechanical Control Systems Laboratory currently employs an outdated device, known as the Motomatic, to teach students about various motor characteristics and control methods. These include open-loop vs. closed-loop control, speed vs. position control, and DC motor response curves. The current device does not function properly and produces unreliable data due to overwhelming non-linear effects such as stiction and shaft misalignment. Our team was tasked with designing a replacement device that retains many of the same educational goals as the original lab procedure, while also adding new educational goals pertaining to the device system dynamics. The new apparatus ...


Poly Spotlight Control, Ryan P. O'Neill, C. Oleg Frandle, Anthony T. Lombardi 2017 California Polytechnic State University, San Luis Obispo

Poly Spotlight Control, Ryan P. O'Neill, C. Oleg Frandle, Anthony T. Lombardi

Mechanical Engineering

When this project began, The Cambria Center for the Arts Theater used a manually-operated spotlight. The sound created by the fans, along with the sheer size of the spotlight, required that it be housed in an attic room above the theater and shined through a closed window. This trapped a lot of heat in the room and involved some risk with climbing into and out of the attic room. This project sought to remedy those issues by mounting a pair of newer LED spotlights inside the theater. Doing this required a method for remotely controlling and actuating the angular position ...


Technical Report On: Towards Reactive Control Of Simplified Legged Robotics Maneuvers, Jeff Duperret, D. E. Koditschek 2017 University of Pennsylvania

Technical Report On: Towards Reactive Control Of Simplified Legged Robotics Maneuvers, Jeff Duperret, D. E. Koditschek

Technical Reports (ESE)

This technical report provides proofs and calculations for the paper "Towards Reactive Control of Simplified Legged Robotics Maneuvers," as well as implementation notes and a discussion on robustness.


Answering Food Insecurity: Serving The Community With Food And Knowledge Using Technology, Courtney Simpson 2017 Purdue University

Answering Food Insecurity: Serving The Community With Food And Knowledge Using Technology, Courtney Simpson

Purdue Journal of Service-Learning and International Engagement

The courses of Tech120, CGT110, and ENGT 180/181 and Red Gold at Purdue collaborated to design a robot that would plant and water a garden for a local community charter school. The students centered the project on the users’ needs for fresh food, nutrition education, and early exposure to STEM for children. The school, Anderson Preparatory Academy (APA), is comprised of many children who come from low-income families and are in the free or reduced lunch program. Inspired from “Farm Bot,” a similar system that allows for almost hands-free gardening, the “Boiler Bot” is designed to be scalable so ...


Additive Manufacturing Process Of 3d Polyaniline Transducers Via Direct Ink Writing, Frederick Benjamin Holness 2017 The University of Western Ontario

Additive Manufacturing Process Of 3d Polyaniline Transducers Via Direct Ink Writing, Frederick Benjamin Holness

Electronic Thesis and Dissertation Repository

Electroactive polymers exhibit a change in properties, typically size or shape, in response to electrical stimuli. One class of electroactive polymer of particular interest are the conjugated polymers, whose conjugated backbone structure imparts electrical conductivity. However, this structure imposes processing limitations restricting their form to 2D structures. To overcome this, we develop specially formulated polyaniline- based blends via counter-ion induced thermal doping for the fabrication of 3D conductive structures via direct ink writing. This approach employs multi-material extrusion for the production of structures with passive and active features, rapid device fabrication, and improved design freedom. A model of the thermal ...


Parallel Computation Using Mems Oscillator-Based Computing System, Xinrui Wang, Ilias Bilionis, Salar Safarkhani 2017 Purdue University

Parallel Computation Using Mems Oscillator-Based Computing System, Xinrui Wang, Ilias Bilionis, Salar Safarkhani

The Summer Undergraduate Research Fellowship (SURF) Symposium

In recent years, parallel computing systems such as artificial neural networks (ANNs) have been of great interest. In these systems which emulate the behavior of human brains, the processing is carried out simultaneously. However, it is still a challenging engineering problem to design highly efficient hardware for parallel computing systems. We will study the properties of networks of Microelectromechanical System (MEMS) oscillators to explore their capabilities as parallel computing infrastructure. Furthermore, we simulate the time-variant states of MEMS oscillators network under various initial conditions and performance of certain tasks. Recent theoretical results show that networks of MEMS oscillators have some ...


Dynamics Of Poly(Methyl Methacrylate)–Montmorillonite Nanocomposites: A Dielectric Study, Weixing Sun, Li Li, Michael R. Kessler, Nicola Bowler 2017 Iowa State University

Dynamics Of Poly(Methyl Methacrylate)–Montmorillonite Nanocomposites: A Dielectric Study, Weixing Sun, Li Li, Michael R. Kessler, Nicola Bowler

Nicola Bowler

The effect of varying amounts of montmorillonite (MMT) filler (in weight ratios of 100/0, 100/5, and 100/10) on the molecular dynamics and polarization of atactic poly(methyl methacrylate) (PMMA) is investigated using broad-band dielectric spectroscopy from 10−2 to 106 Hz and at temperatures from 30 to 140 °C. The experimental data were analyzed with the sum of Havriliak–Negami (HN) functions and a power-law conduction term. The characteristic frequency, activation energies, and dielectric strength of PMMA/MMT nanocomposites were analyzed. As MMT content increases, a Maxwell–Wagner–Sillars (MWS) relaxation emerges in the nanocomposites and the ...


Dissertation Xu V1.Pdf, Jiawen Xu 2017 University of Connecticut - Storrs

Dissertation Xu V1.Pdf, Jiawen Xu

Jiawen Xu

The objective of this dissertation research is on the designing and optimization of promising wave guiding and energy manipulation approach.  Specifically address above-mentioned issues of modeling and application of piezoelectric metamaterials and energy harvesting.  The first research task is to develop fundamental modeling and understanding of piezoelectric metamaterial integrated with LC shunts to create local resonances.  We establish the lumped-parameter model of the piezoelectric metamaterial.  Transverse wave is considered throughout the modeling and analysis, and the lumped parameters are derived based on the wavenumber involved.  Taking advantage of the model, we identify the influence of a key parameter, the system-level ...


Development Of Portable Hyperspectral Imaging Device, Chenxi Li, Youngkee Jung, Iyll-Joon Doh, Euiwon Bae 2017 Purdue University, Department of Agricultural and Biological Engineering

Development Of Portable Hyperspectral Imaging Device, Chenxi Li, Youngkee Jung, Iyll-Joon Doh, Euiwon Bae

The Summer Undergraduate Research Fellowship (SURF) Symposium

Most of the conventional hyperspectral imaging devices require sophisticated optical components, occupy a large footprint, and requires an initial capital investment for laboratories which mostly suits for laboratories benchtop system. The requirement of shipping the sample and waiting an extended period of time to get the results are the main downsides of this traditional approach. Capitalize in many specific field applications and diagnosis, portable devices provide both convenience and on-site results which are desirable for government agencies and food safety inspectors. This project was aimed to develop a low-cost, portable hyperspectral device for food safety applications. A smartphone was used ...


Piezoelectric Bistable Buckled Beam Energy Harvester., Brian Edward Allgeier 2017 University of Louisville

Piezoelectric Bistable Buckled Beam Energy Harvester., Brian Edward Allgeier

Electronic Theses and Dissertations

A novel energy harvesting device design is presented to be created via microfabrication techniques. Such devices have countless applications for powering low-current electrical devices, especially wireless sensors or transmitters. This micro-electromechanical system (MEMS) design utilizes the piezoelectric response of a bistable buckled beam to gather electrical energy via ambient vibrations. While many traditional piezoelectric energy harvesters (PEH) consist of simple cantilever beam geometries, this nonlinear design utilizes inertial effects of torsional lever arms to actuate a central buckled beam to snap between its two stable states; such an abrupt strain on the piezoelectric beam potentially produces a significantly increased electrical ...


Thermoelectric System Modeling And Design, Buddhima Pasindu Gamarachchi 2017 Boise State University

Thermoelectric System Modeling And Design, Buddhima Pasindu Gamarachchi

Boise State University Theses and Dissertations

Thermoelectric generators (TEGs) convert heat to electricity by way of the Seebeck effect. TEGs have no moving parts and are environmentally friendly and can be implemented with systems to recover waste heat. This work examines complete thermoelectric systems, which include the (TEG) and heat exchangers or heat sinks attached to the hot and cold sides of the TEG to maintain the required temperature difference across the TEG. A 1-D steady state model is developed to predict the performance of a TEG given the required temperatures and device dimensions. The model is first validated using a 3-D model and then is ...


Design And Experimentation Of Cable-Driven Platform Stabilization And Control Systems, Matthew Newman 2017 University of Nebraska-Lincoln

Design And Experimentation Of Cable-Driven Platform Stabilization And Control Systems, Matthew Newman

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Agricultural researchers are constantly attempting to generate crops superior to those currently in use by the world. Whether this means creating crops with greater yield, crops that are more resilient to disease, or crops that can tolerate harsh environments with fewer failures, test plots of these experimental crops must be studied in real-world environments with minimal invasion to determine how they will perform in full-scale agricultural settings. To monitor these crops without interfering on their natural growth, a noninvasive sensor system has been implemented. This system, instituted by the College of Agricultural Sciences and Natural Resources at the University of ...


Design And Experimentation Of Cable-Driven Platform Stabilization And Control Systems, Matthew Newman 2017 University of Nebraska - Lincoln

Design And Experimentation Of Cable-Driven Platform Stabilization And Control Systems, Matthew Newman

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Agricultural researchers are constantly attempting to generate crops superior to those currently in use by the world. Whether this means creating crops with greater yield, crops that are more resilient to disease, or crops that can tolerate harsh environments with fewer failures, test plots of these experimental crops must be studied in real-world environments with minimal invasion to determine how they will perform in full-scale agricultural settings. To monitor these crops without interfering on their natural growth, a noninvasive sensor system has been implemented. This system, instituted by the College of Agricultural Sciences and Natural Resources at the University of ...


An Analysis Of Testing Variables In Rapid Compression Machine Experiments, Jenna Ezzell 2017 Marquette University

An Analysis Of Testing Variables In Rapid Compression Machine Experiments, Jenna Ezzell

Master's Theses (2009 -)

There have been discrepancies noted with regards to experimental data from rapid compression machines (RCM). When data is compared from different RCM facilities, the ignition delay times are inconsistent when inspecting any particular temperature. Currently in publications, if these datasets are compared, the discrepancy is said to be due to heat loss, however this issue has yet to be examined more thoroughly. To determine what the root cause of this discrepancy is, four different fake RCM facilities were created and simulated. There were also different sets of initial conditions used to determine how this may affect the data. They were ...


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